Wendy Xin

Our new paper showcasing molecular connectomics with pan-expansion microscopy is out in @natbiotech.nature.com! www.nature.com/articles/s41...
This wonderful collaboration with @bewersdorflab.bsky.social was led by Ons M'Saad (now founder/CEO of Panluminate) and @allisonphysics.bsky.social. (1/5)

Yay!!!! Huge congrats Rafa!!! 🎉🎉🎉🎉

A flyer displaying the same information as written in the post, with two images of two astrocytes around a blood vessel and one newly formed oligodendrocyte, along with logs our sponsors Avantor and Plasmidsaurus.

If you are attending #SfN25, please join @amygleichman.bsky.social and I on Monday at 9PM for a casual social gathering to discuss all things non-neuronal!

Date: Monday, Nov 17th
Time: 9PM till close
Location: The Smoking Gun SD, 555 Market St.

All welcome, please free to spread the word!

Flyer for a social for Glial Interactions at SfN. Monday Nov 17, 9PM-close, The Smoking Gun, 555 Market St. Microscopy images of two astrocytes (top, red/blue) and an oligodendrocyte and myelin sheaths (bottom, white/red).

If you’re interested in the roles of glia in stroke and TBI, kick off #SfN2025 with a minisymposium on Saturday afternoon in room 6B!

@droligo.bsky.social and I are also hosting a glia get-together Monday night, sponsored by Avantor and @plasmidsaurus.bsky.social - all glia-inclined are welcome!

Party tiiiiime 🍺🍻🍾🥂🕺💃🪩

The Gowrishankar lab will be opening its doors @neuro_MUSC on Dec 1, 2025! We will be hiring at all levels. I will also be at @SfNtweets presenting my lab's vision on Wednesday, Nov 19, 8AM-12PM at poster board GG7. If you're interested, please reach out!

www.raajgowrishankarlab.org

Spatial dynamics of brain development and neuroinflammation - Nature A tri-omic atlas of the mouse brain from postnatal day 0 to P21 reveals that layer-specific projection neurons have a role in coordinating axonogenesis and myelination.

Our latest collaboration with @rongfan8.bsky.social, spatial triomics to investigate myelin and cortical brain development, and demyelination, spearheaded by Leslie Kirby in our lab @ki.se and Di Zhang in Rong's lab! Check it out @nature.com

www.nature.com/articles/s41...

Audiobook cover of How to Change a Memory: One Neuroscientist’s Quest to Alter the Past by Steve Ramirez, read by the author

In How to Change a Memory, neuroscientist @okaysteve.bsky.social shares his disarmingly personal account of the new science of memory manipulation.⁠
⁠
🎧️📔 The #audiobook, read by the author himself, is out now!

Add it to your #audio library: press.princeton.edu/books/audio/...

Meet our 2025 cohort of Next Generation Leaders! For the next 3 years, they will network with other rising stars, participate in professional development, and share their ideas for future research directions.

Important article from @marymunson4.bsky.social @joann-trejo.bsky.social @needhibhalla.bsky.social

Retinal glia regulate development of the circadian photoentrainment circuit Circadian photoentrainment depends on intrinsically photosensitive retinal ganglion cells (ipRGCs), which convey environmental light information to th…

Our latest paper is out! While the circadian photoentrainment circuit has been extensively studied, the mechanisms regulating its development remain poorly understood. Here we show that retinal Müller glia play a key role in this process. Check it out! www.sciencedirect.com/science/arti...

Molecular mechanisms mediating engram ensemble retrievability state in mice Engrams, ensembles of neurons that store memories, exist along a continuum of retrievability. Normally, sensory cues can reactivate a latent engram to…

Excited to share the latest from the lab on the molecular mechanisms of silencing and un-silencing a hippocampal engram ensemble. Was fun using a variant of the EPSILON technique developed by Adam Cohen's lab.
(1/2)

www.sciencedirect.com/science/arti...

A flyer displaying the same information as written in the post, with two images of two astrocytes around a blood vessel and one newly formed oligodendrocyte, along with logs our sponsors Avantor and Plasmidsaurus.

If you are attending #SfN25, please join @amygleichman.bsky.social and I on Monday at 9PM for a casual social gathering to discuss all things non-neuronal!

Date: Monday, Nov 17th
Time: 9PM till close
Location: The Smoking Gun SD, 555 Market St.

All welcome, please free to spread the word!

SCIENTIST – Developmental, Stem Cell & Cancer Biology Program - Toronto (City), Ontario (CA) job with The Hospital for Sick Children - Developmental & Stem Cell Biology Program | 12848200 Discovery-based and/or translational research using model organism genetics and/or stem cell and organoid platforms to study paediatric cancer.

Fantastic opportunity at The Hospital for Sick Children. Please repost. www.nature.com/naturecareer...

I am proud to share our work on X-linked Dystonia-Parkinsonism — a rare neurodegenerative movement disorder driven by a SINE-VNTR-Alu retrotransposon insertion in the TAF1 gene.

Read our two companion papers:
🔹 www.biorxiv.org/content/10.1...
🔹 www.biorxiv.org/content/10.1...

🧵 Highlights below!

New paper from the lab 🚨
Led by Ali Golbabaei, this study explores the how the composition of prefrontal cortical engrams changes with memory age:
authors.elsevier.com/a/1lzT-3BtfH...

In the desert of tools to manipulate oligodendrocytes in the brain, we built an OASIS. 🌿 Pun intended. I’m still in awe every time I spot an amazing-looking cell. The beauty of OL and myelin never fails me!
Hope this tool helps more people see it too.

Just out in Nature! “The astrocytic ensemble acts as a multiday trace to stabilize memory.” We identified astrocytic ensembles that link experiences across days to stabilize memory nature.com/articles/s41.... New astrocyte tools are openly available at Addgene: addgene.org/Jun_Nagai/. 1/8

Regionally mapped astrocytic responses to cortical and white matter stroke show differential roles in astrocyte-induced vascular remodeling Stroke is a major cause of disability. Astrocytes respond to stroke in a gradated manner, but details of that response and its consequences for tissue…

Thrilled to share this work from my postdoc with Tom Carmichael, available online @ Neuron! Long story short: we find even more evidence that all reactive astrocytes are not equal, and we can take advantage of those differences to improve repair after stroke.
www.sciencedirect.com/science/arti...

Fluorescently labeled astrocytes at varying distances from cortical or white matter stroke infarct border

Huge congrats @amygleichman.bsky.social on this phenomenal study, demonstrating regional differences in astrocyte responses to stroke and a key role for astrocytes in post-stroke angiogenesis and repair!

(see also - gorgeous astrocytes for fluorescence Friday)

www.sciencedirect.com/science/arti...

Come join us at @westernu.ca: Chair, Department of Medical Biophysics: www.uwo.ca/facultyrelat...

PhD / Postdoc in Neuroscience – University of Montreal - Seeking a highly motivated PhD student or Postdoctoral Fellow to join an exciting collaborative project between the laboratories of Dr. Antonio Nanci and Dr. Ravi Rungta at the Université de Montréal. can-acn.org/phd-postdoc-...

This is reassuring, no need for the upcharge!

Hahaha all feedback welcome

Patch clamp friends, anyone have experience with the Digidata HumSilencer feature? Does it do anything?

Autism and Tylenol: Exploring the Evidence on Acetaminophen in Pregnancy - NAM Margaret McCarthy discusses the genetics of autism, how to interpret associations with Tylenol (acetaminophen) use in health studies, and why medical guidance matters.

Interview with @pegmccarthy.bsky.social on the *evidence* related to Tylenol and pregnancy

nam.edu/news-and-ins...

Thrilled to share our new paper @cp-cell.bsky.social:
“Microglia–astrocyte crosstalk regulates synapse remodeling via Wnt signaling.”

This work demonstrates the necessity of glia–glia communication and coordination during synapse remodeling.

🔗 www.cell.com/cell/fulltex...

Faust et al., Cell 2025

Adaptor protein complex 2 (AP2) participates in biogenesis and homeostasis of myelin sheaths in the central nervous system Myelination of CNS axons requires oligodendrocytes to undergo extensive morphological changes by producing large amounts of myelin membrane with defined protein composition and structure. The formatio...

If you're interested in trafficking of #myelin constituents in #oligodendrocytes, and of course you are, you may want to check out our new preprint. It's very nice PhD work by @sophiesiems.bsky.social, and we're grateful to all who contributed!

www.biorxiv.org/content/10.1...

We are looking for a new coordinator to join the Education & Engagement team at @alleninstitute.org! This person will support the full breadth of our efforts here in the program, including administrative support, participant communications, helping with field trips, and much more. 1/2

Cell-type-selective synaptogenesis during the development of excitatory connectivity in the mammalian neocortex The function of mammalian neocortex relies on the timing of axon extension and establishment of cell-type-biased patterns of excitatory synaptic connections. A subtype of excitatory neurons, layer 6 c...

Excited to share our new preprint from my graduate work, a collaboration between the Brown lab and @srirams433.bsky.social and others in the Kolodkin lab! Our study investigated how patterned excitatory connectivity is generated in the development of the cerebral cortex (1/7)