well-Red librarian 😷🔻

THIS IS HUGE! Researchers at Scripps Research Institute have developed a groundbreaking UNIVERSAL coronavirus vaccine that triggers STONG immune responses AND shows promise in neutralizing MULTIPLE coronaviruses, including those responsible for causing COVID-19, MERS, AND even the “common cold.” 🧪🧵⬇️

SUMMARY In a groundbreaking advance in the field of immunology, scientists have developed a novel "low-sugar" vaccine that aims to provide a broad protective effect against various coronaviruses, including the one responsible for COVID-19. Recent studies conducted at Scripps Research reveal that the newly engineered vaccine targets not only the virus itself but also the sugar molecules, known as glycans, that cloak the virus, thereby shielding it from detection by the immune system. This innovative strategy harnesses the potential to create long-lasting immunity, simplifying the vaccination process for future infectious disease threats. STORY HIGHLIGHTS The universal vaccine can offer protection from multiple coronaviruses, even those causing the flu and common cold. It would eliminate the need to update the COVID-19 vaccine.

ABSTRACT Glycosylation is an important reaction used to modulate the structure and function of biomolecules in living organisms. Most human viruses, for example, depend on the host glycosylation machinery to create a sugar coat on the virus to complete their life cycle. We found that the main immunogens of influenza and COVID viruses are highly glycosylated I, particularly in the conserved epitopes, to facilitate infection and escape from immune response. We also found that deletion of the sugar coat to expose the highly conserved epitopes elicited broadly protective antibody and T cell responses against the virus and different variants. In addition, the antibodies induced by such low-sugar vaccines are more diverse with higher titers against the immunogen, especially the highly conserved epitopes, thus broadening the scope of protection. Furthermore, the Fc-glycans on the antibody can be engineered to improve antibody-mediated killing. This lecture will present our recent development of broadly protective low-sugar vaccines and glycoengineered antibodies with improved Fc-mediated killing.

Removing the glycans (dark blue on the left illustration) from a coronavirus’ spike protein leads to greater vaccine efficacy. Credit: Lorenzo Casalino, edited

Chi-Huey Wong, a chemistry professor at Scripps Research, presented his team’s findings on March 25th at the ACS Spring 2025 Digital Meeting hosted by the American Chemical Society.

This research was funded by Academia Sinica.
• acs.digitellinc.com/p/s/developm...

This looks like an incredible book, and you should buy it or ask your library to buy it

IMO the #MeToo movement was smothered in 2020

multiple women made credible allegations that Joe Biden had harassed and abused them, and many centrists felt these should be swept under the rug so Biden could beat Trump

he was one of the worst candidates from 2020 IMO

www.thecut.com/2020/04/joe-...

Is it safe to travel with your phone right now? Know your rights, but also minimize your risk.

news you can use:
www.theverge.com/policy/63426...

Minnesota Just Became The Latest State to Eliminate Prison Gerrymandering A new law will end the practice of counting incarcerated people where prisons are located, which skews political power within the state.

Did you know? Earlier this year, Minnesota became the latest state to eliminate prison gerrymandering.

A new law, signed by Tim Walz in the spring, will end the practice of counting incarcerated people where prisons are located, which skews political power within the state.

Domestic deployment of the military, explained An overview of critical reforms concerning the domestic deployment of the U.S. National Guard.

yes and no

here's an article about the legal side

but also: the law only exists to the degree that it is enforced. if/when Trump does unconstitutional shit and neither Congress nor SCOTUS stop him, then what? the cops won't arrest the Natl Guard

protectdemocracy.org/work/domesti...

"Absolutely Insane": Pentagon Officials on Trump's Military Deportation Plan Trump campaigned on mass deportations. Now he’s threatening to use the U.S. military to carry them out.

Trump campaigned on mass deportations. Now he’s threatening to use the U.S. military to carry them out.

Prison Abolition Resource Guide “Remember to imagine and craft the worlds you cannot live without, just as you dismantle the worlds you cannot live within.”Ruha Benjamin This guide contains resources on the abolition of policing,…

since more people are coming here, here's the abolition resource guide I put together for those who may be interested! micahherskind.com/abolition-re...

the system preceding race and gender integrated education and DEI was not even facially "meritocratic" - elite higher ed served as finishing schools for rich failsons, half of admissions criteria were invented to keep out Jews. the naked cronyism is the America they wanted to return to "greatness"

NEW: Mayor Brandon Johnson says his revised 2025 budget proposal now includes a $150 million property tax hike, as negotiations continue with members of the City Council. The owners of a property worth $250,000 would likely pay approximately $120 more a year, if approved.

if u are wondering about that red pin emoji here 📌

if u find a post u want to return to u can stick a pin in it by replying with the red pin emoji

then use @jaz.bsky.social's red pin feed which keeps track of your red pins

Cover of the zine "A Librarian Against AI; or, I Think AI Should Leave", featuring a design of bold color blocks inspired by the opening titles of the TV show "I Think You Should Leave"

📣 New zine!! "A Librarian Against AI; or, I Think AI Should Leave" is a 40-page zine about why we should think twice about using & supporting generative AI. violetbfox.info/against-ai/ #noAI #zines

Warren famously said that the Constitution required the creation of every right necessary to serve the public good. And he meant it too. In the sixteen years Warren was Chief Justice, the Supreme Court issued the opinions in Miranda v. Arizona (yes, that's where "Miranda rights" comes from);

4/

another curmudgeonly thread for the many of you who will be entering organizing spaces.

all other things being equal, when confronted with one team of people recruiting you to Be a Thing and another team recruiting you to Do a Thing, please give serious thought to joining the second.

nobody at the level of power we say we're aiming to contest - who could launch an ICBM, capital strike, or planetary scale disinformation campaign - is worried about the fine details of our lil critiques, or precisely what kind of socialist/anarchist/anti-imperialist is frowning at them. be serious.

Cannot stress this enough. Political purity does not get things done. Finding areas where you can work together is the essence of coalition-building.

The vast majority of Chicago voters who ditched the Dems - did not go for Trump either

Today’s Chicago City Council regrets the infamous 2008 parking meter deal • The TRiiBE 16 years later, Chicago alders who voted for former mayor Richard J. Daley’s parking meter deal talk about its lasting impact on the city budget.

Monday's must-read:

Our reporter @corli.thetriibe.com spoke to Black alders who voted in favor of Daley's infamous parking meter deal in 2008.

“So it was a bad deal and it was a mistake made, and now we’re living to regret it."

Read the story to see what they said.

thetriibe.com/2024/11/toda...

When we say there are intersections to disability and race, listen.
-Over policing and criminalization of Black children
-Lack of awareness and empathy for disability

In an astonishing moment of Chicago City Council brevity, aldermen just voted (50-0 to kill Mayor Brandon Johnson's proposed $300 million property tax hike proposal) without any floor debate. I was taking the over on a 90-minute debate over/under.

Episode 38: The Media’s Bogus Generation Obsession Citations Needed | May 23, 2018 | Transcript

the people responsible for the world being on fire are corporate executives, not senior citizens

the way to fix things is to beat corporate executives, not wait for the olds to die off

generational conflict ❌
class conflict ✔️

citationsneeded.medium.com/episode-38-t...

Hochul is a clown who should've implemented the bill as written, several months ago

we need to replace her ASAP

people who use goodreads: jeff bezos owns goodreads and if you want a better alternative there is a black woman owned company called storygraph that you can use to replace it. you can transfer all of your data from goodreads to storygraph and have your mind be free of trumpie jeff bezos! win win. 💙

One of the smallest acts of resistance you can do right now that will do very much to signal that you are on the side of reason and democracy is where a mask. Start protecting yourself and others from the pandemic. it’s also a very subtle show of defiance and community.

Māori MPs briefly suspended the Aotearoa parliament’s attempts to reinterpret their founding treaty in the most bad ass use of the Haka I’ve ever seen.

THREAD: I’m going to share this thread here to clearly state my perspective on electric vehicles, car dependency and better cities, for all those who frequently ask me about it, including media, elected leaders and many others. Here goes. Please share it frequently if you think it will help. 🧵#EVS

New York City mayor praises Elon Musk as efficiency head Eric Adams continues his soft touch with Trump, declining to opine on the nomination of Matt Gaetz as attorney general.

You can always count on Eric Adams — to be in the wrong side of anything and everything

"we welcome both cis and trans women" seems more straightforward and concise, while still conveying inclusivity