The perfect addition to our Christmas tree: an ES cell and a cancer cell, knitted by the super talented @cathieerb

From 2023: out now in @plosbiology.org
👇 TLDR: Transcription CAN directly remodel TADs... in specific contexts. Big congrats to Sanjay and @yousra_zouari
who spearheaded the project, and @djost_physbiol
+Hossein

We've now joined BlueSky - we'll try and catch up with all the Twitter/X expats asap

Massive thanks to
@kerstinbys.bsky.social, @tinekelenstra.bsky.social, @mitchell_lab, @akispapantonis.bsky.social, @molina_lab, @EviSoutoglou and team members, and @NeoVirTech
for their valuable contributions

Competition between transcription and loop extrusion modulates promoter and enhancer dynamics The spatiotemporal configuration of genes with distal regulatory elements, and the impact of chromatin mobility on transcription, remain unclear. Loop extrusion is an attractive model for bringing gen...

Quite rehashed from the original bioRxiv: biorxiv.org/content/10.1... but the message is inherently the same

Transcription processes compete with loop extrusion to homogenize promoter and enhancer dynamics Gene promoters and enhancers share the same constrained mobilities during transcription, opposing cohesin-mediated loop extrusion.

Out now in
@ScienceAdvances
👇 science.org/doi/10.1126/... A great team effort, spearheaded by Angeliki, showing that promoter and enhancer dynamics become homogenized on transcriptional activation, and that loop extrusion and transcription compete to put brakes on chromatin