Pat Madden

Simultaneous immunization with three germline-targeting immunogens primes multiple bnAb lineages in NHPs, advancing multiepitope HIV vaccine strategies @sciimmunology.bsky.social @profshanecrotty.bsky.social SchiefLab @lji.org @scripps.edu
www.science.org/doi/10.1126/...

The only thing standing between humanity and the end of HIV Even Trump is fast-tracking this innovative new drug. What could go wrong?

Me in Vox.com on the need for ambitious global roll out of the revolutionary HIV prevention injection lenacapavir--and how Vought's theft of PEPFAR funding & State's Jeremy Lewin's weak approach and ideological bent will sabotage the effort--unless we fight back:

www.vox.com/future-perfe... >>

AIDS Activists Arrested at Sen. Collins’ Office, Demanding She Reverse Chokehold on Appropriated PEPFAR Funds for Lifesaving HIV Prevention and Treatment Press StatementFor Immediate Release: October 14 2025Contact: Asia Russell, Health GAP:  (267) 475 2645 | asia@healthgap.orgElizabeth Koke, Housing Works: (646) 342 9350 | e.koke@housingworks.orgMarie...

🚨BREAKING:🚨 AIDS activists arrested occupying Senator Collins' DC office, demanding she stop GIVING IN to Russ Vought's illegal & deadly withholding of global HIV funding.

See: healthgap.org/press/aids-a...

Simultaneously, bodybags delivered to her Portland office by Maine activists 👇

Local B-cell immunity and durable memory following live-attenuated influenza intranasal vaccination of humans Seasonal influenza vaccines are most frequently delivered as intramuscular inactivated vaccines which elicit systemic responses against the immunodominant hemagglutinin (HA) head domain. An intranasal...

In our new study we show local B-cell immunity and durable memory following live-attenuated influenza intranasal vaccination of humans. We utilized minimally invasive swabbing of human upper airway, following seasonal intramuscular or nasal (FluMist) flu vaccinations
www.biorxiv.org/content/10.1...

Call these U.S. Representatives and tell them to vote NO on the “Big Beautiful Bill”: AZ-06, Juan Ciscomani CA-22, David Valadao CA-40, Young Kim CA-41, Ken Calvert CO-08, Gabe Evans FL-07, Cory Mills FL-13, Anna Paulina Luna FL-27, Maria Elvira Salazar IA-01, Mariannette Miller-Meeks IA-02, Ashley Hinson IA-03, Zach Nunn MI-07, Tom Barrett MO-02, Ann Wagner NJ-07, Tom Kean Jr. NY-17, Mike Lawler OH-07, Max Miller OH-10, Mike Turner OH-15, Mike Carey PA-01, Brian Fitzpatrick PA-07, Ryan Mackenzie PA-08, Rob Bresnahan PA-10, Scott Perry TN-05, Andy Ogles TX-15, Monica De La Cruz VA-01, Rob Wittman VA-02, Jen Kiggans WI-01, Bryan Steil WI-03, Derrick Van Orden

These are the weak points. You know what to do. First thing tomorrow, use 5calls.org and raise hell.

MERKLEY: How do you feel about being responsible for hundreds of thousands of kids dying because of your sudden interruption in these key programs?

VOUGHT: I reject the assertion

MERKLEY: I find your response both ignorant & callous. Few Americans have had a more devastating & disastrous impact

Chris Murphy: "Trump & the Republicans are trying to engineer the most massive transfer of wealth from the poor & middle class to the wealthy in history of the country...that's super unpopular. So how do you pass it? You can only pass it if you also destroy democracy & the means of accountability"

Nobel laureate on how Trump's cuts are hurting science Neuroscientist, biologist and 2021 Nobel Prize winner Ardem Patapoutian joined Midday Edition to talk about how the Trump administration's effort to cut back on science spending is impacting researche...

I spoke with Jade Hindmon, host of @kpbssandiego.bsky.social Midday Edition, about the consequences of the current administration’s cuts to science funding. Please share to help spread the word and raise awareness.
www.kpbs.org/podcasts/kpb...

Robert F. Kennedy Jr. is a clear and present danger to every person in the United States, and in fact in entire world.

He must be REMOVED FROM OFFICE IMMEDIATELY.

NIH details how Trump budget would cut support for grants, training, and research centers President Trump's 2026 budget proposes cutting NIH grants to universities, academic medical centers, and other institutions by 43%

~40% cuts to NIH research awards.
~35% cuts to training programs.
~27% cut to internal research.
~30% fewer grants awarded overall.
The Common Fund will be cut in half.
American science has never faced a threat like this.
www.statnews.com/2025/06/06/n... via @statnews.com

must be incredibly frustrating and disheartening to have federal funding that was promised to you for important work suddenly and arbitrarily ripped away

The Continuing Crisis, Part XV: The Horrendous Trump Budget

The administration’s budget proposal is a disaster in so many ways, but it is most certainly a direct assault on US science.

Nothing like it has ever been seen before, and it means that we will have voluntarily stepped aside from a leading role in the scientific progress of the entire human race.

snap cuts, growing to 35% by 2034

chip and medicaid cuts growing to 12-14% by 2034

Cost estimate of the House-passed "Big Beautiful Bill" is out

It'd be the largest cut to Medicaid+CHIP and SNAP in history while still increasing deficits by $2.4 trillion due to $3.8 trillion in tax cuts

This'd be the largest transfer of wealth from the poor to the rich in a single law in history

DOGE is now reviewing every NIH grant that goes out, I reported last week.

That review is AI-driven and is screening for DEI, trans health, China, vaccine hesitancy, and the institutions to whom Trump has blocked funding, @hannahnatanson.bsky.social reports.

Gift link: wapo.st/3HhnPSt

“Out Of His Depth,” “Sold His Soul,” “Clueless”: NIH Staffers Speak Out About Director Bhattacharya Widespread dissatisfaction over the NIH’s “continuous free fall” has people speaking out.

NEW: Important Context spoke with a dozen people working at NIH about Director Jay Bhattacharya.

The descriptions were universally unflattering, painting the health economist as ineffectual, dishonest, ideological, arrogant, and uncommitted to science.

www.importantcontext.news/p/out-of-his...

Go, Elon, and Never Darken Our Doors Again The worst ultra-billionaire on Earth says he’s leaving government. Let’s hope he actually does it.

"Roughly 1,500 babies have been born HIV-positive every day since January 21, because Musk cut off their mothers’ medication." prospect.org/power/2025-0...

White House Health Report Included Fake Citations

The New York Times has found at least two more fake citations in the MAHA report.

www.nytimes.com/2025/05/29/w...

Atul Gawande on Instagram: "“No children are dying on my watch,” said Rubio. It's blatantly false. So far, 190,000 children and 90,000 adults have died due to the dismantling of USAID (even assuming... 9 likes, 0 comments - atul.gawande on May 24, 2025: "“No children are dying on my watch,” said Rubio. It's blatantly false. So far, 190,000 children and 90,000 adults have died due to the dismantlin...

“No children are dying on my watch,” said Rubio. It's blatantly false. Credible estimates count 190K deaths so far.

In Kenya, I am seeing devastating impact, incl this child's starvation & many deaths directly caused by Rubio’s actions. More in my @msnbc.com clip. www.instagram.com/atul.gawande...

Trump’s Lie about Dead “White Farmers” Just Got Even More Grotesque That photo he brandished to Cyril Ramaphosa was from the Democratic Republic of Congo—whose refugees the Trump administration is pointedly not welcoming to America.

Unreal: To sustain his lie about a "genocide" of "white farmers" while meeting with the South African president, Trump used a photo of war deaths in the Democratic Republic of Congo.

I looked into this a bit more. It's worse than it first appeared. 1/

(new piece)
newrepublic.com/article/1956...

The Cost of Silence: A Call to Protect the Future of HIV Research and Care Loreen Willenberg, William Freshwater, Dawn Averitt, Linda H Scruggs, Marc C E Wagner, Waheedah Shabazz-El, Wanda L London, Paul A Edmonds, Christopher Tun

The Cost of Silence: A Call to Protect the Future of #HIV Research and Care academic.oup.com/jid/advance-...

Begging @jidjournal.bsky.social to make this paper open access - an article about the cost of silence is going to remain unheard by many people otherwise.

THIS IS HUGE! TWO Phase I HIV vaccine clinical trials have demonstrated that a stepwise mRNA-based vaccination strategy can SUCCESSFULLY activate AND advance immune responses toward producing broadly neutralizing antibodies (bnAbs), a CRITICAL milestone in HIV prevention. Let’s talk about that! 🧪🧵⬇️

Shane Crotty elected to American Academy of Arts and Sciences LA JOLLA, CA—Immunologist Shane Crotty, Ph.D., Professor and Chief Scientific Officer at La Jolla Institute for Immunology (LJI) has been elected to the American Academy of Arts and Sciences. Crotty w...

Congratulations to LJI Prof. and CSO Dr. Shane Crotty! Crotty's research has advanced our fundamental understanding of the immune system.

bit.ly/3ScESHh #SanDiego #health #medicine

A 10-foot microscope reveals big lessons about the tiniest threats to the human body A technological revolution is helping Scripps Research scientists see the molecules that undermine human health, from COVID-19 to cancer — and hopefully fight them.

The revolution in resolution
Titan Krios—"It routinely lets us see life's tiniest machines—proteins, viruses and the atoms they combine—with breakthrough clarity."
www.sandiegouniontribune.com/2025/04/27/a...

Haunted by hopelessness: 12 Zambians share their stories as HIV drugs run out Mothers and children, husbands and wives, doctors, truck drivers and religious leaders are all grappling with the fallout from the sudden U.S. cuts in aid.

I look at close to 100 stories a week and even more outside of work. I’ve done this ten years.

This is among the most horrific things I’ve ever read — testimony from dying children whose access to medicine has been cut off by the Trump administration.

www.npr.org/sections/goa...

The US funding cuts have had a seismic impact on HIV responses across East and Southern Africa. But governments, civil society organisations, and international partners are stepping up to protect lifesaving HIV services.

Latest updates show how the region is adapting: www.unaids.org/en/resources...

Happy to share my first postdoc publication from the Crotty lab! We used HIV germline targeting immunizations as a model system to study rare B cell recruitment into germinal centers to better understand the immunological principles underpinning B cell priming. Nice thread below...

We simply had to intentionally destroy the world’s strongest economy while dismantling our scientific and educational infrastructure to ensure that a team with a trans girl would never finish second place in the Mountain West volleyball standings again

NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.

It’s the economy stupid- “There is no better investment than one that saves lives, supports local economies and drives America’s global leadership in biomedical innovation” www.forbes.com/sites/michae...

A Broad Survey and Functional Analysis of Immunoglobulin Loci Variation in Rhesus Macaques Rhesus macaques (RMs) are a vital model for studying human disease and invaluable to pre-clinical vaccine research, particularly for the study of broadly neutralizing antibody responses. Such studies ...

Very proud of this collective effort to enhance understanding of immunoglobulin diversity in rhesus macaque @guryaari.bsky.social @williamlees.bsky.social
www.biorxiv.org/content/10.1...
--> NEW and IMPROVED germline sets for this important animal model...explore here: vdjbase.org/reference_bo...