Philippa Melamed

Figure showing the anatomy of the adult and developing tuberal hypothalamus.

This Review discusses the intricate molecular mechanisms and signalling pathways that control the development of the tuberal hypothalamus, focusing on aspects that shape metabolic outcomes (£) go.nature.com/4qAwCQS
#EndoSky #MedSky

Developmental transcription factors display a range of targeting H3K9me3 heterochromatin to open chromatin, for cell fate changes
www.science.org/doi/10.1126/...

Models of hyperglycaemia in diabetes mellitus and its complications - Nature Reviews Endocrinology Many different models are used in research into diabetes mellitus, and each has strengths and limitations. In this Review, the authors explain several in vivo and in vitro models of hyperglycaemia and...

Our lab specialises on Stem Cells, Beta Cells and Diabetes. Naturally, we think a lot about glucose and what hyperglycaemia means. Have a read on our latest review in Nat Rev Endo to find out more!

#atlab #stemcells #diabetes #research #imcb #astar #nus

www.nature.com/articles/s41...

Congrats to Ariel, Yuval and all those involved. @chromatech.bsky.social

Let the data speak — single-cell analysis with CellWhisperer Nature Reviews Genetics, Published online: 02 January 2026; doi:10.1038/s41576-025-00927-xIn this Tools of the Trade article, Moritz Schaefer introduces CellWhisperer, a multimodal machine learning model and software tool for the chat-based interrogation of single-cell RNA sequencing datasets.

New online! Let the data speak — single-cell analysis with CellWhisperer

As usual this time of year, started drafting the list of gene regulation conferences for 2026, enjoy! generegulation.org/conferences-...
Know of a relevant event that’s missing? Please reply below

⭐NAR Breakthrough! ⭐
🧬 A synthetic RNA forms a #G-quadruplex without a G-rich sequence, using a complex 3D fold and GTP as a ligand. This suggests G-quadruplexes may be far more widespread in biologically important RNAs. Read more: doi.org/10.1093/nar/...

#NARBreaktrhough #RNA #StructuralBiology

SET1/MLL complexes control transcription independently of H3K4me3 Histone H3 lysine 4 trimethylation (H3K4me3) at gene promoters is thought to play a central role in gene transcription. H3K4 methylation is deposited by the SET1 (A/B) and MLL (1-4) multi-protein comp...

Excited to share our new preprint from the Klose lab, where we investigate how SET1/MLL complexes shape H3K4me3 and regulate transcription in mouse ES cells. www.biorxiv.org/content/10.6...

Are you ready for the 17th edition of 'Transcription and chromatin'? Our conference remains a must-attend event for anyone engaged in the forefront of transcription research and we hope you can join us! 🧬

25 – 28 August 2026
Submit your abstract by 25 May: s.embl.org/trm26-01-bl

#EMBLTranscript

🚨Reposts appreciated‼️If I had read this PhD offer five years ago, I wouldn’t have hesitated for a second to apply 😉
Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social 🧬✨

#PhD #3DGenome

Deaminase-assisted single-molecule and single-cell chromatin fiber sequencing Gene regulation is mediated by the co-occupancy of numerous proteins along individual chromatin fibers. However, our tools for deeply profiling how proteins co-occupy individual fibers, especially at ...

What an amazing assay.

DAF-seq, the evolution of Fiber-seq from the Andrew Stergachis group, using the @pacbio.bsky.social platform:
www.biorxiv.org/content/10.1...

This will revolutionise our understanding of transcriptional regulation and functional non-coding variants.

Epigenetics and Gene Regulation in Health and Disease: Linking Basic Mechanisms with Therapeutic Opportunities | Keystone Symposia Join us at the Keystone Symposia on Epigenetics and Gene Regulation in Health and Disease: Linking Basic Mechanisms with Therapeutic Opportunities, March 2026, in Geneva, with field leaders!

On behalf of @ckadoch.bsky.social and myself, we are pleased to present our upcoming @KeystoneSymposia, #KSEpigenetics26 Epigenetics and Gene Regulation in Health and Disease, March 2-5, in Geneva, Switzerland. keysym.us/KSEpigenetic...

Is enhancer-driven gene regulation all wrapped up? - Nature Reviews Genetics In this Comment, Wendy Bickmore discusses mechanistic models of how 3D genome organization facilitates communication between distant enhancers and their target promoters to regulate gene expression.

www.nature.com/articles/s41...

FEBS Advanced Lecture Course: 6th Danube Conference on Epigenetics The FEBS Advanced Lecture Course: 6th Danube Conference on Epigenetics will take place 19–22 October 2026 in Budapest, Hungary. Here we give a taste of the scientific content, flag some of the speaker...

Do not forget to apply to the FEBS Advanced Lecture Course: 6th Danube Conference on Epigenetics (19–22 October 2026, Budapest, Hungary. Will be a great meeting as always. Check out the site: network.febs.org/posts/febs-a...

Pls add us also - chromatin, enhancers and transcription in the context of hormones. Thx.

FACT weakens the nucleosomal barrier to transcription and preserves its integrity by forming a hexasome-like intermediate Burgos-Bravo et al. use single-molecule optical tweezers to monitor the effect of the histone chaperone FACT on transcription through nucleosomes. FACT functions on nucleosomes initially unwrapped by ...

FACT weakens the nucleosomal barrier to transcription and preserves its integrity by forming a hexasome-like intermediate: Molecular Cell www.cell.com/molecular-ce...

👇

High-throughput transcriptome analysis reveals a developmental increase in Acvr1c which mediates epigenetic repression of the gene encoding the pubertal brake, Makorin ring finger protein 3 Abstract. Makorin ring finger protein 3 (MKRN3) acts as a “pubertal brake.” MKRN3 loss-of-function mutations are the most common genetic cause of central p

Latest from our lab - great work from Dor...for those interested in #Mkrn3, #puberty, #reproduction, #chromatin, #transcription, #bioinformatics.

Great to see this from a former student in my NUS lab - Adrian @drainteo.bsky.social - looks like a good read.

Optical control of gene expression using a DNA G-quadruplex targeting reversible photoswitch Nature Chemistry - Dynamic gene expression is crucial for coordinating diverse cellular activities, but challenging to modulate with high spatiotemporal precision. Now, a photoswitchable DNA...

👇
rdcu.be/egkqK

The R Graph Gallery – Help and inspiration for R charts The R graph gallery displays hundreds of charts made with R, always providing the reproducible code.

Ever stuck choosing the right plot or trying to figure out how to make it look just right? My go-to resource is the R Graph Gallery (r-graph-gallery.com), which is full of examples and clear code for everything from scatterplots to Sankey diagrams! #dataviz #rstats #rladies

First map of human brain mitochondria is ‘groundbreaking’ achievement Nature - Hundreds of cubes of human brain tissue help scientists to chart the energy-making capabilities of various brain regions.

🧪 Scientists have created the first map of mitochondria throughout the entire brain

https://go.nature.com/42j9YCV

CUT&Tag recovers up to half of ENCODE ChIP-seq histone acetylation peaks - Nature Communications Cleavage Under Targets & Tagmentation is a rapidly expanding technique, but thorough evaluation and benchmarking against established ChIP-seq datasets are required. This study shows that CUT&T...

We're so thrilled to finally share with you the published version of our CUT&Tag optimization and benchmarking paper "CUT&Tag recovers up to half of ENCODE ChIP-seq histone acetylation peaks" - out in @naturecomms.bsky.social today: www.nature.com/articles/s41...

our work on the molecular differences between transcription factor isoforms is out now in Molecular Cell!

key point: 2/3rds of TF isos differ in properties like DNA binding & transcriptional activity

many are "negative regulators" & misexpressed in cancer

www.sciencedirect.com/science/arti...

Two more weeks to send us your abstract! >20 abstract selected talks. Priority to junior scientists and cool biology on gene regulation (DNA/RNA/protein). Come to meet the world leaders in single molecule genomics and single molecule imaging! Help shaping the future of the field in the workshops!

G-quadruplexes and their unexpected ability to fold proteins | PNAS G-quadruplexes and their unexpected ability to fold proteins

Have a look at our newest commentary in @pnas.org :

"G-quadruplexes and their unexpected ability to fold proteins"

Full text: www.pnas.org/doi/10.1073/...

#G4 #quadruplex #proteins #folding

Exportin-1 functions as an adaptor for transcription factor-mediated docking of chromatin at the nuclear pore complex Many genes physically interact with the nuclear pore complex (NPC), which requires transcription factors (TFs). Ge et al. show that the exportin Crm1 binds TFs and nuclear pore proteins to dock chromatin at the NPC and to stimulate transcription. This function of Crm1 is distinct from its role in nuclear export.

Exportin-1 functions as an adaptor for transcription factor-mediated docking of chromatin at the nuclear pore complex

A GnRH neuronal population in the olfactory bulb translates socially relevant odors into reproductive behavior in male mice - Nature Neuroscience Studying GnRH neuroendocrine cells in the mouse olfactory bulb (GnRHOB neurons), Decoster et al. show that these cells respond to female odors and their activation regulates males’ female-odor prefere...

Congratulations to Laurine Decoster and collaborators from our lab on getting the The SNE Impact 2024 on their paper "A GnRH neuronal population in the olfactory bulb translates socially relevant odors into reproductive behavior in male mice" 👏👏🎉🎊

www.nature.com/articles/s41...

Short-term evolutionary implications of an introgressed size-determining supergene in a vulnerable population Nature Communications - The thorny skate is a vulnerable species in the northwest Atlantic ocean with a discreet size polymorphism. Here, the authors have sequenced 49 thorny skate individuals,...

This is cool
rdcu.be/eeGyj

Women twice as likely to develop Alzheimer's disease as men - but scientists do not know why - Nature Medicine Changes to the female brain during menopause, together with social and cultural factors, might affect disease risk.

Women are twice as likely to develop Alzheimer’s disease as men. A feature in Nature Medicine reports how the changes to the female brain during menopause, along with social and cultural factors, might affect disease risk. #medsky #alzsky 🧪