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David Castillo-Azofeifa

@davidc-a.bsky.social

Principal Scientist/Group Leader @genentech, interested in the diverse regenerative strategies of tissues and how they fail later in life. From CR πŸ‡¨πŸ‡· https://www.gene.com/scientists/our-scientists/david-castillo-azofeifa

52 Followers  |  103 Following  |  3 Posts  |  Joined: 22.02.2025  |  1.3723

Latest posts by davidc-a.bsky.social on Bluesky

Huge congrats to the whole team! A special shout-out to Tony Korcari, Helen Tauc, and Jeff Duggan for spearheading this work.

23.07.2025 20:57 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
Preview
Maladaptive inflammatory signaling in old mice impairs colonic regeneration by promoting a sustained fetal-like epithelial state Aging is associated with a decline in the regenerative capacity of many tissues. Central to this decline is a complex interplay between inflammation and stem cell function. How these two processes are...

Our new preprint: doi.org/10.1101/2025...
IFNΞ³ is a double-edged sword for gut regeneration. Young guts: transient burst heals. Aged guts: prolonged upregulation impairs repair by trapping cells in a fetal-like stateπŸ”₯πŸ“‰ #immunology #inflammaging #aging #stemcells #regeneration

23.07.2025 20:57 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Congrats!!! πŸŽ‰

23.05.2025 17:56 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

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