David Castillo-Azofeifa

Huge congrats to the whole team! A special shout-out to Tony Korcari, Helen Tauc, and Jeff Duggan for spearheading this work.

23.07.2025 20:57 — 👍 0    🔁 0    💬 0    📌 0

Maladaptive inflammatory signaling in old mice impairs colonic regeneration by promoting a sustained fetal-like epithelial state Aging is associated with a decline in the regenerative capacity of many tissues. Central to this decline is a complex interplay between inflammation and stem cell function. How these two processes are...

Our new preprint: doi.org/10.1101/2025...
IFNγ is a double-edged sword for gut regeneration. Young guts: transient burst heals. Aged guts: prolonged upregulation impairs repair by trapping cells in a fetal-like state🔥📉 #immunology #inflammaging #aging #stemcells #regeneration

23.07.2025 20:57 — 👍 0    🔁 0    💬 1    📌 0

Congrats!!! 🎉

23.05.2025 17:56 — 👍 1    🔁 0    💬 0    📌 0