RPTH

Great news - the abstracts from our National Conference are now published in RPTH, ISTH’s open access journal.

The nearly 100 abstracts are individually indexed and citable—offering lasting value to researchers, clinicians, and institutions worldwide.

Read the full issue here: buff.ly/JoQ5Kpp

🚨 Exciting opportunity alert: Join the @rpth.bsky.social editorial team! RPTH is currently accepting applications for 3 Associate Editors (AE):⁠
✅2 Social Media AEs⁠
✅1 AE with expertise in inherited & acquired bleeding disorders⁠
📅Starting Jan 2026
⁠
Learn more: www.isth.org/news/news.asp?id=710939

Join our editorial team!

ISTH is partnering with Inari, now a part of Stryker, for #WorldThrombosisDay 2025! Together we’re advancing #VTE care through a new educational offering:
🎧 The Role of Mechanical Thrombectomy in Transforming VTE Care

Launching Oct 16 on the ISTH Pulse Podcast.
🔗 www.worldthrombosisday.org

Intestinal transplantation can have complex hemostatic complications.

This study of 145 transplants reports bleeding (38%) and thrombosis (26%) in their patient cohort.

Read more here to learn about the risks and management! www.rpthjournal.org/article/S247...

🧬This team reports a new #prothrombin mutation (Ile441Met) linked to #venousthromboembolism in a Han Chinese family. Thrombin generation assays show clear hypercoagulability in carriers.

Details here: www.rpthjournal.org/article/S247...

Combined oral contraception (COC) alters hemostasis in ways standard labs may underestimate.

Thrombin generation assays with anti-PS and anti-TFPI antibodies revealed a marked reduction in anticoagulant activity after just 3 months of COC use.

www.rpthjournal.org/article/S247...

Children with cancer are at a high risk of developing venous thromboembolism, and post-thrombotic syndrome is a concern. Do central venous catheters play a role?
This research letter reports findings from a cross-sectional study of 50 pediatric cancer patients.

www.rpthjournal.org/article/S247...

Are you curious about AI and if it can improve diagnosis of hemostasis and thrombosis? 🖥️

This review covers the potential uses of AI in clinical practice.

Read about it here:
www.rpthjournal.org/article/S247...

#artificialintelligence #machinelearning #thrombosis #hemostasis

Cautious use of activated prothrombin complex concentrate in patients receiving emicizumab: new evidence and clinical considerations Emicizumab (EMI), a bispecific monoclonal antibody that mimics the function of activated factor (F)VIII and is not recognized by anti-FVIII antibodies, has established itself as the prophylactic…

This #commentary from Cedric HERMANS MD PhD FRCP discusses the use of activated prothrombinase complex concentrate in patients on #emicizumab.

www.rpthjournal.org/article/S247...

The original article being discussed is here:

www.rpthjournal.org/article/S247...

Radiotherapy—the not-so-insignificant contributor to cancer-associated venous thrombosis Venous thromboembolism is a well-established complication in patients with cancer and a leading cause of morbidity and mortality in these subjects. However, the role of radiotherapy in cancer-associat...

Cancer-associated thrombosis (CAT) is a significant healthcare concern; not all of causes are understood.

This review by Gerard Gurumurthy, Jacob Miller, Marc Carrier, Alok Khorana, and Jecko Thachil explores the potential role of radiotherapy CAT risk

🖇️ www.rpthjournal.org/article/S247...

🎙️New ISTH Pulse Podcast episode! Nearly 40 years ago, Dr. Israels & Dr. Rand met at an ISTH Congress. Today, the two colleagues & friends sit down to discuss their research, careers & how the ISTH helped them cultivate a lifelong friendship

👉bit.ly/41pyVvK

📝 Open for Comment: The ISTH G&G Committee seeks your feedback on the draft manuscript "Surgical & Procedural Bleed Risk Stratification: Guidance for Anticoagulated Patients."

👉 lnkd.in/g5MgzCRg

Your expertise is requested!
Take this survey from the @ISTH.org #SSC Subcommittee on Lupus Anticoagulant/Antiphospolipid Antibodies on
✅APS diagnosis and antithrombotic treatment in patients with acute ischemic cardiac disease
to assess current clinical practices

💡Turn your exciting research into high-impact publications!
Whether you presented at #ISTH2025 &/or have some other new & exciting science to share, watch this interview w/our editors & learn more about submitting to @ISTH.org @jthjournal.bsky.social or @rpth.bsky.social
bit.ly/46TLcfk

Radiotherapy may independently increase the risk of venous thromboembolism. 🩸⚡

This review in @rpth.bsky.social unpacks mechanisms, diagnostic challenges, and why thromboprophylaxis should be tailored rather than routine.

👉 doi.org/10.1016/j.rp...

#Thrombosis #Oncology #CancerResearch

Have you registered? There’s still time to join!

💡Don't miss this week's @ISTH.org @rpth.bsky.social Research Recap on
✅"Beyond #Platelet Activation: Dysregulated Lipid Metabolism in Derfining Risk and Pathophysiology of VITT" w/author Hanna Stevens, moderated by @mtl-plateletlab.bsky.social
🗓️Aug 14: 08:15 ET (US) / 12:15 UTC
buff.ly/r2mYcSU

Gynecological and obstetric complications in women with congenital fibrinogen deficiencies:

In qualitative fibrinogen deficiencies, the rates of live birth, postpartum hemorrhage, and miscarriage were 58%, 47%, and 42%, respectively.

See the details here:
www.rpthjournal.org/article/S247...

This excellent commentary from Tzu-Fei Wang discusses a recent study about bleeding risk after a fall in people taking anticoagulants for atrial fibrillation.🩸

Commentary: www.rpthjournal.org/article/S247...
Article: www.rpthjournal.org/article/S247...

New insight into thrombotic mechanisms of SARS-CoV2 infection?

Using drosophila genetic screening, Quan Zhang and team identified orf7a as a trigger for endothelial activation and release of von Willebrand factor, and may result in thrombosis.

www.rpthjournal.org/article/S247...

Acetaldehyde is a pollutant found in tobacco and eCig smoke, cosmetic products, and the product of alcohol metabolism. And did you know it can affect fibrin structure?

Read more about the effect of this common toxicant on the fibrinolytic system!
www.rpthjournal.org/article/S247...

New study from Steven Humphreys reveals that arterial and venous endothelial cells elongate and remodel differentially in response to flow rate.

Arterial endothelial cells are more responsive to inflammation and significantly delay clot breakdown.

More here: www.rpthjournal.org/article/S247...

A small panel of VWF variants were investigated for expression and function - and how they might cause Von Willebrand Disease.

Golzar Mobayen and team reveal that the D4 and C-domains of VWF might play a role!
📖 www.sciencedirect.com/science/arti...

Hanqiang Deng provides excellent commentary on an outstanding article about heterogeneous responses to shear stress in different endothelial cell subtypes.

Commentary here: www.rpthjournal.org/article/S247...
Original Article by Allaura Cox and Christopher Ng: www.rpthjournal.org/article/S247...

This study from Eva Kempers and team examined menstrual blood loss and related quality of life among women on antiplatelet therapy and a control group.

Their data reveal that both outcomes were comparable, great news for women who need antiplatelet therapy.

www.rpthjournal.org/article/S247...

This new study investigates adenoviral vector vaccine-associated thrombosis/thrombocytopenia risk.

✅ Adenoviral vectors can infect megakaryocytes
✅ Concurrent infection may increase chemokine receptor expression

Check out the results here:
www.rpthjournal.org/article/S247...

ISTH 2025 Congress abstracts now published in @rpth.bsky.social!

Take a few moments to review the groundbreaking science that is being shared in Washington, D.C. Click here to view: www.rpthjournal.org/issue/S2475-...

The @rpth.bsky.social and @jthjournal.bsky.social Editors presented the Editors awards this afternoon, including this one to Daniel Steiner.

Have you explored the #ISTH2025 abstracts yet?

There’s no better way to kick off your week than diving into the latest in thrombosis and hemostasis research.