Insights into Imaging

Deputy Editor Elisabetta Giannotti has expanded her area of expertise to include Breast Imaging and Sustainability, and we can announce we warmly welcome submission on these important topics.

🔹 Two-center study, n=245
🔹 AUC: 0.884 (training), 0.829 (validation)
🔹 High DLRN score → 16.3× higher relapse risk (p<0.001)
🔹 Best prediction when combined with Metro-Ticket 2.0 (AUC: 0.936/0.863) (Ziqian Wu et al.)

insightsimaging.springeropen.com/articles/10....

📢 New article in #InsightsintoImaging

Researchers developed a CT-based Deep Learning Radiomics Nomogram (DLRN) to predict early recurrence of hepatocellular carcinoma (HCC) after liver transplantation.

🔹 100% technical success
🔹 Adverse events: 8.3% grade I, 2.8% grade III (none in benign cases)
🔹 Complete imaging response: 55.6% metastatic, 100% benign

➡️ MWA is a safe & effective option for pain palliation and local control in bone lesions. (Sylvain Bodard et al.)

shorturl.at/GVMZL

📢 New article in #InsightsintoImaging

Microwave ablation (MWA) of bone lesions was evaluated for feasibility, safety & efficacy in 43 patients (51 lesions).

🔹 Blood supply is central to fibroid genesis, diagnosis & treatment
🔹 Ultrasound & MRI reveal complex vascular composition
🔹 Authors propose a generic nomenclature to standardize terminology (Derk Jan Slotman et al.)

#InsightsintoImaging

insightsimaging.springeropen.com/articles/10....

A new #InsightsintoImaging narrative review: The role of blood flow & vasculature in uterine fibroids and how imaging can improve clinical care.

🔹 584 patients (2010–2022), median follow-up 5.8 yrs
🔹 OS: similar between LTP & IDR (70.3 vs 93.1 mo, p=0.974)
🔹 PFS: worse in LTP (13.8 vs 20.9 mo, p=0.028)
🔹 ≥3 LTP episodes = markedly reduced OS (44.9 mo, p=0.031) (Guo et al.)

#InsightsintoImaging

shorturl.at/Ikd7C

This multicenter study compared outcomes of radiofrequency ablation (RFA) for local tumor progression (LTP) vs intrahepatic distant recurrence (IDR) in recurrent hepatocellular carcinoma (rHCC).

🔹 Best-performing model: Combined Phase
🔹 AUCs: 0.831 (training), 0.785 (internal), 0.746 (external)
🔹 Stratified OS (p=0.011) & DFS (p=0.022)
🔹 RNA-seq linked to fibrosis production & remodeling (Fangqing Wang et al.)

insightsimaging.springeropen.com/articles/10....

📢 New article in #InsightsintoImaging

A multicenter study developed a CT radiomics model to predict fibrosis grade in pancreatic ductal adenocarcinoma.

The review also highlights contrast-enhanced mammography as an alternative when MRI is unavailable and introduces an updated diagnostic algorithm to support clinical decision-making and improve patient outcomes. (Pitarch et al.)

#FromTheExperts #InsightsintoImaging

shorturl.at/uu4Hg

It outlines a stepwise approach beginning with ultrasound and mammography, progressing to MRI when initial imaging is negative. With MRI’s high negative predictive value, surveillance may replace surgery in select cases.

This educational review provides a practical guide for breast radiologists in evaluating pathological nipple discharge, emphasizing the role of imaging in reducing unnecessary surgeries.

New study shows a combined clinical and radiomics model can:
✅ Preoperatively predict intratumoural tertiary lymphoid structures
✅ Stratify recurrence-free survival after surgery
✅ Identify patients likely to benefit from immunotherapy (Ying Xu et al.)

#InsightsintoImaging

shorturl.at/dFhGU

🩺📷 Predicting tertiary lymphoid structures in gallbladder cancer using MRI #radiomics

✅ Left ventricular remodeling index ≥7.5 linked to higher risk of lethal ventricular tachyarrhythmias
✅ Independent predictor beyond conventional cardiac magnetic resonance parameters
✅ Offers incremental value for risk stratification (Xi Jia et al.)

#InsightsintoImaging

shorturl.at/3QrP0

🫀📷 Left ventricular remodeling index predicts ventricular tachyarrhythmia

New study in patients with nonischemic dilated cardiomyopathy and left ventricular ejection fraction below 35%:

✅ Ischemic cardiomyopathy: good agreement with unipolar mapping
✅ Non-ischemic cardiomyopathy: moderate to fair agreement
✅ Feasible even in patients with cardiac devices (Victor Mergen et al.)

#InsightsintoImaging

insightsimaging.springeropen.com/articles/10....

🫀📷 Photon-counting CT for ventricular arrhythmias

This study shows late enhancement photon-counting CT can characterize pathologic left ventricular segments with good agreement to endocardial electroanatomical mapping:

✅ External test AUC = 0.93
✅ Outperforms baseline deep learning (AUC 0.46–0.72) and machine learning models (0.49–0.60)
✅ Alpha-Fetoprotein biomarker added little benefit (Lulu Jia et al.)

#InsightsintoImaging

insightsimaging.springeropen.com/articles/10....

A new ResNet-ViT Contrastive Learning (RVCL) model predicts the macrotrabecular-massive (MTM) subtype of HCC from contrast-enhanced CT.

A wonderful time in Valencia last week at the ESOR/ESR Journals Advancing Excellence In Manuscript Review Workshop – a huge thanks to all that attended and all the speakers! 🇪🇸 📖

#InsightsintoImaging

insightsimaging.springeropen.com/articles/10....

Study of 2,908 requests in Italy:
- Only 21% had adequate referral quality (RI-RADS A/B)
- 25% were “usually not appropriate” (ACR)
- Inappropriate CTs rarely detected acute disease (1% vs 11%, p<0.001)
- Headache & syncope = most frequent unjustified indications (Marco Parillo et al.)

🧠📊 Head CT in the ED: are referrals appropriate?

The study concludes that while ultrasound shows promise, offering women informed choices and involving them in decision-making is essential to ensure acceptance and maintain quality care. (Carmen C. N. Siebers et al.)

#InsightsintoImaging #FromTheExperts

shorturl.at/uverm

Attitudes were also shaped by healthcare system dynamics and trust in medical professionals. The findings highlight the importance of clear communication, patient education, and shared decision-making.

Many participants appreciated ultrasound’s comfort and lower cost, but concerns about missed cancers, limited scientific evidence, and personal health factors led to mixed views.

This study explored women's perspectives on replacing mammography/DBT with ultrasound as the first-line imaging for focal breast complaints.