Morgane Thion

👉 Microglia colonization exhibits temporally distinct waves of proliferation.
👉 Neuronal activity is not a major driver of early microglial colonization.

👉 Neural 𝘊𝘴𝘧𝟣, mainly derived from neural progenitors, drives cortical embryonic microglia.
👉 In transient hotspots where microglia adopt an ATM-like state, their intrinsic 𝘊𝘴𝘧𝟣 expression sustains their proliferation.

🙏🙏🙏 Sonia Garel, Cécile Bridlance, Sarah Viguier, @nicolas-olivie.bsky.social, Edmond Dupont, Dorine Thobois, Benjamin Mathieu & our precious collaborators @estherkli.bsky.social, @aymericsilvin.bsky.social, Florent Ginhoux, Melanie Greter, Brukhard Becher, @guillelbendito.bsky.social & JeanX Jiang.

🧠 Check out our new study!
Cécile Bridlance et al. reveal how distinct, local, and cell-type–specific sources of CSF-1 orchestrate microglial colonization during early brain development.

🙏🙏🙏 A big thank you to everyone involved!

👉 Neural 𝘊𝘴𝘧𝟣, mainly derived from neural progenitors, drives cortical embryonic microglia.
👉 In transient hotspots where microglia adopt an ATM-like state, their intrinsic 𝘊𝘴𝘧𝟣 expression sustains their proliferation.

🙏🙏🙏 Sonia Garel, Cécile Bridlance, Sarah Viguier, @nicolas-olivie.bsky.social, Edmond Dupont, Dorine Thobois, Benjamin Mathieu and our precious collaborators @estherkli.bsky.social, @aymericsilvin.bsky.social, Florent Ginhoux, Melanie Greter, Brukhard Becher, @guillelbendito.bsky.social & JX Jiang.

Mark your calendars!
The 28th Meeting of the French Glial Cell Club will take place Nov 17–20, 2026, in Sète.
🔹 Plenary lectures by Fiona Doetsch & Leda Dimou
🔹 5 symposia on glial diversity, astrocytes, human glia, EVs & modeling
👉 Full program available on our website: frenchglialcellclub.fr

Interested in the heterogeneity of blood vessels in the CNS? Here we review the unique features of the spinal cord vasculature, its barrier properties and neurovascular interactions, highlighting unknown aspects and future research directions.
@CRC1366
@erc.europa.eu @immunosens.bsky.social

Developmental programming by maternal obesity alters offspring lifespan and immune responses in a diet- and sex-specific manner Maternal obesity is a growing health concern that predisposes offspring to metabolic dysfunction, immune system alterations, and neurodegenerative dis…

1/ 💡We are excited to share our latest paper, continuing our exploration of how maternal obesity programs offspring health via #macrophages - this time using #Drosophila as a model: shorturl.at/28tFo

#MaternalObesity #Drosophila #Neurodegeneration #DOHaD #FlyResearch #MacrophageBiology

🧠 New book chapter out!

We review the developmental origin and functional diversity of #microglia - key players at the crossroads of #immunity and #neurodevelopment.

🔹 Ontogeny & specialization
🔹 Transcriptional & metabolic shifts
🔹 Roles in disease & repair
👉 authors.elsevier.com/a/1lKxcErwXf...

Kupffer cell programming by maternal obesity triggers fatty liver disease Nature - In a mouse model, maternal obesity during pregnancy can lead to fatty liver disease in the offspring, driven by aberrant developmental programming of Kuppfer cells.

We are SO EXCITED to share our story @nature.com:
🧵1/
Maternal obesity reprograms fetal liver macrophages, triggering adult fatty liver disease in the offspring.
This study uncovers how Kupffer cells act as intergenerational messengers in metabolic disease.
👉 Read here: rdcu.be/erD3b

Physiological and injury-induced microglial dynamics across the lifespan Tieu, T. et al. leveraged in vivo two-photon live imaging of microglia, the brain’s resident immune cells, to reveal striking differences in their morphology, basal dynamics, and injury responses acro...

#NewResearch from the #VcoelhoSantosLab and #ShihLab used #two-photon live imaging to reveal how #microglia 🧠 evolve across across #lifespan.

Key findings:
👶 Neonatal: Active but clumsy
🧍‍♂️ Adult: Calm but sharp
👵 Aged: Quiet and slow

@ucoimbra.bsky.social @lacaixa.bsky.social

📣Join us for the DEVELOPMENTAL BIOLOGY COURSE @institutcurie.bsky.social @sorbonne-universite.fr
We have fantastic speakers and registration is free!
training.institut-curie.org/courses/deve...
@karinayaniv.bsky.social @doetschlab.bsky.social @eileen-furlong.bsky.social @jesseveenvliet.bsky.social

Still openings, check it out!

Our special issue on #neuroimmunology is online! Check out the collection, with reviews from @jonykipnis.bsky.social @michellemonje.bsky.social @ugolinis.bsky.social @bethstevenslab.bsky.social @movahedilab.bsky.social Matteoli, Butovsky, Kim, Artis, & Prinz! www.cell.com/immunity/col... #AAI2025

Interleukin-34-dependent perivascular macrophages promote vascular function in the brain The niche signals critical for the homeostasis and functions of the brain border-associated macrophages (BAMs) are not well understood. Van Hove et al. demonstrate that BAMs require IL-34 derived from mural cells and perivascular fibroblasts for their maintenance in adulthood. They show that BAMs are required to promote normal vascular function in the brain.

Online now: Interleukin-34-dependent perivascular macrophages promote vascular function in the brain

🎉 Excited to share that our paper on FCDII is out today! 🙌🏻 Huge thanks to @sbaulac.bsky.social and @sara baldassari for bringing me on board and introducing me to the complexity of somatic mutations. Hope our work helps advance understanding of the disease mechanisms.

#Communiqué | L'Université PSL et ses établissements s’associent au mouvement @standupforscience.bsky.social et invitent toutes leurs communautés académiques, scientifiques, étudiantes et administratives à participer à la journée du jeudi 3 avril 2025.
Infos 👉 psl.eu/actualites/d...

📢New webinar coming soon📢 
Prof. Steffen Jung from Weizmann Institute of Science will be our next speaker on April 1st. Check all the information in the flyer and add it to your calendar! 🧠🔬

Registration to the Glial Cell Day for Young Researchers - May 13, 2025 - Montpellier (France) | Club des Cellules Gliales The French Glial Cell Club is happy to organize a new meeting focused on glial cells on May 13, 2025 in Montpellier, just before the NeuroFrance...

We are pleased to announce that the registration for the 2nd Young Glial Cell Day which will take place in Montpellier on May 13, 2025!

👉 club-de-cellules-gliales.assoconnect.com/collect/desc...

Abstract submissions for oral and poster presentations will close on March 28, 2025.
See you soon!

#StandUpForScience
Science not silence!

We stand in solidarity with the #StandUpForScience movement and with all researchers working in the United States, where academic freedom is currently being challenged.

✨ We tend to think of species-specific differences as resulting from the presence of species-specific genes. In our latest work with @djabaudon.bsky.social, we show that building brains is not only about which genes you use, but also about when and where you do.
www.biorxiv.org/content/10.1...

À l’occasion de la Journée internationale des femmes et filles de science, testez vos connaissances sur les femmes scientifiques et l’égalité dans la recherche.
👉 mpdf.cnrs.fr/le-quiz-femm...

#FemmesEnScience #WomenInScience

A valuable post to educate our peers on this #InternationalDayofWomenandGirlsinScience
Thanks @frantecol.bsky.social for putting this together.
Especially relevant for these dark days for USA science🧪

How does pregnancy change a mum's brain? 🤰

Òscar Vilarroya, at Universitat Autònoma de Barcelona, investigates these transformations, seeking to understand how a mother's brain adapts during this life-changing period.

Read more about his recent results. erc.europa.eu/projects-sta...

🧠Job Opening!🧠

We are opening 2️⃣! positions
– bioinformatics / molecular biology –
in a project studying how temporal patterns set up connectivity in human brain tissue.
@institutimagine.bsky.social.

Full details below, contact me for details if interested.
And please retweet (re-bluesky?)!

Cette année, mon cours @collegedefrance.bsky.social traitera de la régulation des gènes par les séquences enhancers. Une des clés de notre développement. Premier cours le vendredi 21 février à 10h. Entrée libre, salle chauffée. Amis et Collègues parisiens, merci de diffuser!

Baisse annoncée du budget de la recherche et de l’enseignement supérieur : quel avenir pour la recherche scientifique ? Le projet de loi de finances 2025, adopté hier au Sénat, prévoit un coup de rabot conséquent sur le budget de la recherche et de l’enseignement supérieur, avec 630 millions d’euros d’économies. Ces re...

Le projet de loi de finances 2025, adopté hier au Sénat, prévoit un coup de rabot conséquent sur le budget de la recherche et de l’enseignement supérieur, avec 630 millions d’euros d’économies.

www.radiofrance.fr/franceinter/...

www.radiofrance.fr/franceinter/...