Abstract The ongoing emergence of severe acute respiratory syndrome coronavirus (SARS-CoV-2) variants of concern that reduce the effectiveness of antibody therapeutics necessitates development of next-generation antibody modalities that are resilient to viral evolution. Here, we characterized amino-terminal domain (NTD) - and receptor binding domain (RBD)-specific monoclonal antibodies previously isolated from COVID-19 convalescent donors for their activity against emergent SARS-CoV-2 VOCs. Among these, NTD-specific antibody C1596 displayed the greatest breadth of binding to VOCs, with cryo-electron microscopy structural analysis revealing recognition of a distinct NTD epitope outside of the site i antigenic supersite. Given C1596's favorable binding profile, we designed a series of bispecific antibodies (bsAbs), termed CoV2-biRNs, that featured both NTD & RBD specificities. Two of the C1596-inclusive bsAbs, CoV2-biRN5 and CoV2-biRN7, retained potent in vitro neutralization activity against all Omicron variants tested, including XBB.1.5, BA.2.86, and JN.1, contrasting the diminished potency of parental antibodies delivered as monotherapies or as a cocktail. Furthermore, prophylactic delivery of CoV2-biRN5 reduced viral load within the lungs of K18-hACE2 mice after challenge with SARS-CoV-2 XBB.1.5. In conclusion, NTD-RBD bsAbs offer promising potential for the design of resilient, next-generation antibody therapeutics against SARS-CoV-2 VOCs.
Diagram showing NTD Antibody + RBD Antibody leading to a combination labeled CoV2-biRN
More realistic diagram rather than the previous geometric one, showing NTD and RBD before and after the new approach has attached itself.
Umm, this is big COVID vaccine news. Nobody tell RFK Jr.
Original thread at link below.
THIS IS HUGE! Researchers at Stanford University have developed a dual-antibody treatment that remains effective against ALL SARS-CoV-2 variants by targeting a less-mutable […]
[Original post on mstdn.ca]
![A meme about wasps that was poorly edited to be wasp positive.
In the top right corner there is a picture of a black, yellow, and orange cicada killer wasp with text next to it that says this one is a cicada killer who are very unlikely to sting humans
From the top left there is text going down the image that says:
Do you see this?
Do you know what this is?
this is a wasp.
It's mission in nature is to live.
It pollinates things.
Some make honey
It is in the order hymenoptera along with bees and ants.
It is a [large blank space] wasp [smile emoticon]
you cannot battle the wasp. most wasps are solitary.
Paper wasps are eusocial meaning they work together to defend the nest and are calm unless they or the nest are threatened.
When you see a wasp, do you know what you do?
You chill out
you move slowly
you hope the wasp has a nice day
And wait for the wasp to finish its business and move on](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:emzgdetz73wedh5ejj2cthdf/bafkreiekjoiaz5jhorbjxzdqp5k7und36kadh765eqn6533shd2w3cyi2q@jpeg)
10.10.2024 14:32 — 👍 2 🔁 0 💬 0 📌 0
