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Elizabeth Manning

@emmanning.bsky.social

Forebrain development, hypothalamus patterning, early morphogenesis. Postdoctoral Researcher with Marysia Placzek at The University of Sheffield

48 Followers  |  60 Following  |  19 Posts  |  Joined: 11.01.2025
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Posts by Elizabeth Manning (@emmanning.bsky.social)

A Day in the Life of an Ensh*ttificator
YouTube video by ForbrukerrΓ₯det - Norwegian Consumer Council A Day in the Life of an Ensh*ttificator

Government-Funded infomercial from Norway striking back at US corporations and the tech Bros for filling the Internet with slop.
youtu.be/T4Upf_B9RLQ?...

01.03.2026 08:20 β€” πŸ‘ 100    πŸ” 46    πŸ’¬ 1    πŸ“Œ 10
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Queensland researchers are using a popular pet fish to test rare genetic variants With a tank of zebrafish, Queensland researcher Jean Giacomotto was able to test a never-before seen genetic variant affecting two babies.

www.abc.net.au/news/2026-01...

26.01.2026 14:19 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Resolving forebrain developmental organisation by analysis of differential growth patterns - Nature Communications Experiments on the embryonic chick brain reveal distinct directional growth patterns and a tripartite hypothalamus, challenging the classic segmented prosomere model and offering an updated view of ho...

Excited to finally share the final/final.doc version of our paper. It's been a journey, but very proud of the result. Well done to all involved, especially @elsieplace.bsky.social

@kchinnaiya.bsky.social , @thomasdwkim.bsky.social, @sethblackshaw.bsky.social πŸ‘πŸ‘

www.nature.com/articles/s41...

26.01.2026 10:23 β€” πŸ‘ 15    πŸ” 6    πŸ’¬ 0    πŸ“Œ 0

Very happy to share our latest article in @natcomms.nature.com !
Also very pleased to be a featured article (beautiful artwork from @elsieplace.bsky.social depicting early chick neurectoderms at increasing stages of development. (waiting patiently in space for the right moment to attack the Earth?)

15.01.2026 12:48 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
AI: What Could Go Wrong? with Geoffrey Hinton | The Weekly Show with Jon Stewart
YouTube video by The Weekly Show with Jon Stewart AI: What Could Go Wrong? with Geoffrey Hinton | The Weekly Show with Jon Stewart

A very good, entertaining and frankly terrifying look at neural networks and AI
www.youtube.com/watch?v=jrK3...

25.10.2025 13:42 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Developmental Biology and Disability - the Node Hopeful monsters. Morphospace. Mutation. Natural variation. Mutagenesis screens. Polymorphism. Deformity. Phenotype. Disease. Adaptation. Anomaly.

β€œDevelopmental biology is fundamentally beautiful. We are no less beautiful for our variation. Instead, perhaps we are more so. Perhaps we are remarkable. Perhaps we are full of wonder.”

Read this insightful post by Bethan on the Node.

thenode.biologists.com/developmenta...

#Disability

22.10.2025 13:15 β€” πŸ‘ 37    πŸ” 16    πŸ’¬ 0    πŸ“Œ 1
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Movie S4

20.03.2025 11:17 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Movie S3

20.03.2025 11:14 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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Movie S2

20.03.2025 11:12 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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Movie S1.2: Temporal progression from HH stage 10 to HH Stage 20 (multi angle).

20.03.2025 11:11 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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Movie S1: Fate map of HH Stage 10 to HH Stage 20 chick neuroepithelium

20.03.2025 11:09 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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Resolving forebrain developmental organisation by analysis of differential growth patterns The forebrain is the most complex region of the vertebrate CNS, and its developmental organisation is controversial. We fate-mapped the embryonic chick forebrain using lipophilic dyes and Cre-recombin...

Our preprint (www.biorxiv.org/content/10.1...) describes how we have fate mapped the chick neural tube and created the most complete forebrain fate map to date. In this thread, I’ll post our movies describing forebrain morphogenesis

20.03.2025 11:01 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Looking forward to the #biologists100 conference in Liverpool next week!

I’m creating a thread below to link to my poster (in collaboration with @elsieplace.bsky.social) so we can share our 4D model of forebrain development.

Come visit us: Poster 200, Session 2 on Wednesday.

20.03.2025 10:59 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
A still image of a stage HH4 gastrulating chick embryo electroporated with 3 different fluorescent reporter genes shown in magenta, yellow and cyan.

A still image of a stage HH4 gastrulating chick embryo electroporated with 3 different fluorescent reporter genes shown in magenta, yellow and cyan.

Need to electroporate and/or live image avian embryos? We hope our new preprint will help you get started:

www.biorxiv.org/content/10.1...

Open EGGbox: an open-source 3D-printed embryonic Gallus gallus toolbox for electroporation and culture/live imaging of avian embryos ex ovo

πŸ§ͺ🐣 #devbio

06.03.2025 14:28 β€” πŸ‘ 34    πŸ” 14    πŸ’¬ 0    πŸ“Œ 0
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Exclusive: Trump plans to revoke legal status of Ukrainians who fled to US, sources say U.S. President Donald Trump's administration is planning to revoke temporary legal status for some 240,000 Ukrainians who fled the conflict with Russia, a senior Trump official and three sources familiar with the matter said, potentially putting them on a fast-track to deportation.

This is a profoundly evil betrayal and a direct reflection of Trump's soulβ€”a disgusting, small, and shameful ghoul who gets off on harming the powerless.
www.reuters.com/world/us/tru...

06.03.2025 13:11 β€” πŸ‘ 341    πŸ” 124    πŸ’¬ 12    πŸ“Œ 7
Planar polarity in the Drosophila pupal wing is oriented by tissue stress but the mechanisms remain unclear. This study uncovers a crucial role for cell flow gradients in promoting planar polarity protein turnover and aligning proximodistal polarity.

Planar polarity in the Drosophila pupal wing is oriented by tissue stress but the mechanisms remain unclear. This study uncovers a crucial role for cell flow gradients in promoting planar polarity protein turnover and aligning proximodistal polarity.

New! 15y after the classic Aigouy et al "Cell Flow Reorients the Axis of Planar Polarity in the Wing Epithelium..." from lab of much missed Suzanne Eaton, we provide our take from post-doc Sara Tan "Tissue shear as a cue for aligning planar polarity in the developing Drosophila wing".
rdcu.be/d81Vn

08.02.2025 16:46 β€” πŸ‘ 7    πŸ” 4    πŸ’¬ 1    πŸ“Œ 0
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Sunrise over Sheffield

22.01.2025 21:12 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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sneak preview of our animation...

13.01.2025 16:11 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Brought to life through the magic of Blender...

For more details and more movies go to our preprint
www.biorxiv.org/content/10.1...

13.01.2025 16:04 β€” πŸ‘ 0    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Check out our fabulous 4D model of forebrain development, created in Blender from imported light sheet scans of HH10-20 dissected chick neuroepithelium, and painstakingly linked together by @elsieplace.bsky.social by combining published fate maps with 100's of our own samples.

13.01.2025 16:02 β€” πŸ‘ 3    πŸ” 2    πŸ’¬ 1    πŸ“Œ 0
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Resolving forebrain developmental organisation by analysis of differential growth patterns The forebrain is the most complex region of the vertebrate CNS, and its developmental organisation is controversial. We fate-mapped the embryonic chick forebrain using lipophilic dyes and Cre-recombin...

Excited to present our new preprint clarifying forebrain developmental organisation. Complex growth patterns shape the forebrain but distort the A-P + D-V axes, hence prior confusion over brain layout. Big love for chicken embryos, simpler to interpret than mouse 🐣1/3 www.biorxiv.org/content/10.1...

13.01.2025 15:36 β€” πŸ‘ 9    πŸ” 4    πŸ’¬ 1    πŸ“Œ 0

Great work from @thomasdwkim.bsky.social and @sethblackshaw.bsky.social labs

13.01.2025 09:11 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

I haven't seen that experiment - I'll have to look it up. Thanks!

12.01.2025 14:38 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Phenomenal effort by @elsieplace.bsky.social for her fist (of many) last author paper!

12.01.2025 13:50 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Resolving forebrain developmental organisation by analysis of differential growth patterns The forebrain is the most complex region of the vertebrate CNS, and its developmental organisation is controversial. We fate-mapped the embryonic chick forebrain using lipophilic dyes and Cre-recombin...

We begin the New Year with two preprints on hypothalamic development. The first, part of a long-term collaboration with Marysia Placzek’s group, investigates the organization of the developing forebrain, and show that current models are (mostly) incorrect./1
www.biorxiv.org/content/10.1...

11.01.2025 23:36 β€” πŸ‘ 84    πŸ” 26    πŸ’¬ 3    πŸ“Œ 6

Excited to share our new preprint:

11.01.2025 15:59 β€” πŸ‘ 4    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0