Jun-Seok Lee's Avatar

Jun-Seok Lee

@junseoklee.bsky.social

10 Followers  |  2 Following  |  14 Posts  |  Joined: 21.12.2024  |  1.6128

Latest posts by junseoklee.bsky.social on Bluesky

Preview
KOREA UNIVERSITY MEDICINE(고려대학교의료원) on X: "🧪Korean Red Ginseng extract (RGE) fights H9N2 flu 🦠but may boost H1N1 in some lung cells 🔄Cell-type matters: effects vary by virus & treatment mode 🎯 Potential for targeted antiviral use. 🔗 https://t.co/XrNpJM54Rs #Ginseng #Influenza #Antiviral #PrecisionMedicine #Virology" / X 🧪Korean Red Ginseng extract (RGE) fights H9N2 flu 🦠but may boost H1N1 in some lung cells 🔄Cell-type matters: effects vary by virus & treatment mode 🎯 Potential for targeted antiviral use. 🔗 https://t.co/XrNpJM54Rs #Ginseng #Influenza #Antiviral #PrecisionMedicine #Virology

It is interesting phenomena that Korean Ginseng has contradicting effect depending on the host cells.
My PhD student, Yevheniia, did hard work to finish this interesting project. If you work on Avian Influenza study, please check this out.

x.com/kumcnews/sta...

doi.org/10.1016/j.ph...

14.07.2025 11:40 — 👍 0    🔁 0    💬 0    📌 0
Post image

It is really happy news that my graduate student, Kostiantyn, from Korea University College of Medicine received the best POSTER award from 20th Asian Chemical Congress at Bangkok, Thailand. Huge congrats!

#chembio #KoreaUniversityCollegeOfMedicine
#AsianChemicalCongress #Bangkok

26.06.2025 12:30 — 👍 1    🔁 0    💬 0    📌 0
Preview
Chemical proteomics for a comprehensive understanding of functional activity and the interactome Traditional mass spectrometry (MS)-based proteomics aims to detect and measure protein expression on a global scale and elucidate the link between protein function and phenotypic characteristics. Alth...

It is Gold Open Access paper, so everyone can check it out. It is quite extensive work so I want to thanks to Kostia for his great contributions.

doi.org/10.1039/D5CS...

#chemoproteomics #targetID #PPI #Interactome #chemicalpharmacology

19.05.2025 09:38 — 👍 1    🔁 1    💬 0    📌 0

My graduate student Kostia and I wrote a comprehensive tutorial review article for researchers who grt interested in this technique, and just published in Chem.Soc.Rev.

19.05.2025 09:38 — 👍 1    🔁 0    💬 1    📌 0

Do you have bioactive compounds/drug molecules and want to unveil the mode of action? Chemoproteomic profiling is a promising solution to reveal the interaction partners in the cells, so to get a sense of how it works.

19.05.2025 09:37 — 👍 2    🔁 1    💬 1    📌 0
Post image 15.04.2025 07:00 — 👍 0    🔁 0    💬 0    📌 0

⭐ Prof. Randy Seeley (University of Michigan, USA)
⭐ Prof. Hiroaki Suga (University of Tokyo, Japan)
⭐ Prof. Sunghoon Kim (Yonsei University, Korea)

15.04.2025 06:59 — 👍 0    🔁 0    💬 1    📌 0

I’m thrilled to announce the launch of the Drug Target Discovery Institute on April 28 at Korea University College of Medicine!
Check out the opening symposium poster & join us for an inspiring symposium featuring three world-renowned keynote speakers:

15.04.2025 06:59 — 👍 1    🔁 1    💬 1    📌 0
Post image Post image Post image

Happy to be in Osaka again & participating 2025 annual meetings in Chemistry Society of Japan (CSJ).
What a beautiful Kansai University campus.
I am honored to be invited for a Keynote lecture in Asian International Symposium. Learned a lot from this fantastic session.

08.04.2025 12:13 — 👍 1    🔁 1    💬 0    📌 0
Preview
[[A]D302-2pm] Asian International Symposium - Natural Products Chemistry, Chemical Biology / Biofunctional Chemistry and Biotechnology / Medicinal Chemistry - | The 105th CSJ Annual Meeting | Confit Thu. Mar 27, 2025 1:00 PM - 3:40 PM JST The 105th CSJ Annual Meeting

March 27 (Thu), 13:00–15:40
Speakers: Yukihiro Itoh (Osaka Univ.), @junseoklee.bsky.social sky.social (Korea Univ.), Haruo Aikawa (Univ. of Tokyo), Gong Chen (Nankai Univ.), Minami Odagi (Tokyo Univ. Agri.), Tuoping Luo (Peking Univ.)
pub.confit.atlas.jp/en/event/csj...

14.02.2025 06:52 — 👍 1    🔁 1    💬 0    📌 0
Preview
Dyad System of BOAHY-BODIPY Conjugates as Novel Photoswitchable Photosensitizers for Photodynamic Therapy Photodynamic therapy (PDT) offers minimally invasive and repeatable cancer treatment options. Despite advancements in photosensitizer (PS) design, the optical control of PS activation remains unexplor...

BOAHY-BODIPY system introduces optical control to photodynamic therapy through photoisomerization, advancing precision therapy.

Great contributions by JH & kostia!

#PDT #Photopharmacology #CancerResearch #BODIPY #photoisomerization

doi.org/10.1021/acs....

01.02.2025 04:32 — 👍 0    🔁 0    💬 0    📌 0
Preview
Dyad System of BOAHY-BODIPY Conjugates as Novel Photoswitchable Photosensitizers for Photodynamic Therapy Photodynamic therapy (PDT) offers minimally invasive and repeatable cancer treatment options. Despite advancements in photosensitizer (PS) design, the optical control of PS activation remains unexplor...

The first photoswitchable photosensitizers for cancer photodynamic therapy (PDT). While light-controlled drug has been extensively studied, PDT agents have remained unexplored as a photopharmacological modality.

01.02.2025 04:32 — 👍 1    🔁 0    💬 1    📌 0

We make a DC50 value table for various AIE and organic fluorophores. If you are in AIE chemosensing, this table can be useful reference data for your design.

#KoreaUnivrtsityCollegeOfMedicine #chemosensor #AIE #DC50

19.01.2025 07:16 — 👍 0    🔁 0    💬 0    📌 0
https://onlinelibrary.wiley.com/doi/10.1002/bkcs.12933

Dis-/aggregation-dependent chemosensing is well-studied, but quantitative insights into supramolecular aggregation remain scarce. Our study introduces a straightforward approach: DC₅₀ plotted against solvent polarity parameters, offering valuable insights for chemosensor design. #AIE
t.co/nU7axereRA

19.01.2025 07:15 — 👍 0    🔁 0    💬 1    📌 0
Preview
Aptamer and N-Degron Ensemble (AptaGron) as a Target Protein Degradation Strategy Target protein degradation (TPD) is a promising strategy for catalytic downregulation of target proteins through various cellular proteolytic pathways. Despite numerous reports on novel TPD mechanisms, the discovery of target-specific ligands remains a major challenge. Unlike small-molecule ligands, aptamers offer significant advantages, owing to their SELEX-based systematic screening method. To fully utilize aptamers for TPD, we designed an aptamer and N-degron ensemble system (AptaGron) that circumvents the need for synthetic conjugations between aptamers and proteolysis-recruiting units. In our AptaGron system, a peptide nucleic acid containing an N-degron peptide and a sequence complementary to the aptamer was designed. Using this system, we successfully degraded three target proteins, tau, nucleolin, and eukaryotic initiation factor 4E (eIF4E), which lack specific small-molecule ligands. Our results highlight the potential of the AptaGron approach as a robust platform for targeted protein degradation.

If you are interested in TPD tech but worried about synthesis of the compound, you can still design your own TPD agent using Aptamer and N-Degron Ensemble (AptaGron) platform. Check out our strategy from our latest study.

pubs.acs.org/doi/10.1021/...

#KoreaUniversity #PROTAC #TPD

22.12.2024 04:23 — 👍 3    🔁 1    💬 0    📌 0

@junseoklee is following 2 prominent accounts