Epilepsia Open

In pediatric and young adult patients with frontal lobe epilepsy, ictal emotional features were common and predominantly negative.
doi.org/10.1002/epi4...

#epilepsy #epilepsiaopen #ILAE #children #frontallobeepilepsy #ictaldefensivebehavior #ictalemotionalfeatures #semiology #youngadult

Epilepsia Open - Recently published articles (August 3, 2025)
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#epilepsy #epilepsiaopen #ILAE #newarticles

Clobazam, stiripentol, and fenfluramine reduce seizures effectively; valproic acid has no significant effect.
doi.org/10.1002/epi4...

#epilepsy #epilepsiaopen #ILAE #antiseizuremedication #DEE #Dravetsyndrome #Drosophilamelanogaster

A smart shirt was used to detect focal impaired awareness seizures (FIAS).
doi.org/10.1002/epi4...

#epilepsy #eplepsiaopen #ILAE #focalimpairedawarenessseizures #machinelearning #physiologicalsignals #seizuredetection #timeseriesprocessing #wearables

4-AP-induced IEDs can erase the LTP and generate LTD-like effects in the hippocampus without presynaptic terminal activation.
doi.org/10.1002/epi4...

#epilepsy #eplepsiaopen #ILAE #IEDs #synapticdepression #DCS #nonsynapticpropagation

Surgical theater (ST) creates 3D, multilayered, interactive models from up to eight separate radiographic and electrophysiological datasets.
doi.org/10.1002/epi4...

#epilepsy #epilepsiaopen #ILAE #augmentedreality #pediatricneurosurgery #surgicaltheater #virtualreality

Carbamazepine is able to reduce the seizures by 87% after chronic treatment in the KCNQ2-DEE mouse model.
doi.org/10.1002/epi4...

#epilepsy #epilepsiaopen #ILAE #carbamazepine #chronictreatment #cognitivedeficits #DEE #KCNQ2

37.2% rural PWEs can achieve one year of seizure freedom after taking medication regularly.
doi.org/10.1002/epi4...

#epilepsy #epilepsiaopen #ILAE #psychologicalconcerns #ruralcommunity #seizurecontrol

As epilepsy-related knowledge increased, negative attitudes toward PWE declined.⁠
doi.org/10.1002/epi4...
⁠
#epilepsy #epilepsiaopen #ILAE #adult #attitude #knowledge

Although LEV did not improve global cognition, it showed promising effects in specific domains, such as visuospatial and executive function.
doi.org/10.1002/epi4...

#epilepsy #epilepsia #ILAE #Alzheimersdisease #cognitivedecline #cognitivetesting #dementia #levetiracetam

Immune cells produce various chemokines and cytokines, affecting the stability and excitability of neurons and thus influencing seizures.
doi.org/10.1002/epi4...

#epilepsy #epilepsia #ILAE #gutmicrobiota #immunecells #Mendelianrandomization

Seizures may activate brain repair systems that enhance resilience to injury and disease.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #evolutionary #immune #pain #plasticity

This joint ILAE/AES initiative identifies common data elements (CDEs) related to the rigor, reproducibility, and transparency in preclinical epilepsy research.
doi.org/10.1002/epi4...

#epilepsy #ilae #epilepsiaopen #commondataelements #preclinical #reproducibility #rigor #transparency

Epilepsia Open - Recently published articles (July 20, 2025)
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#epilepsy #epilepsiaopen #ILAE #newarticles

Long‐term outcomes of corpus callosotomy in adult patients with drug‐resistant epilepsy: Results from a single neurosurgical center in Mexico Long-term outcomes of corpus callosotomy in adult patients.

Corpus callosotomy was shown to be an effective long-term measure to decrease seizure burden in adults with drug-resistant epilepsy
doi.org/10.1002/epi4...

#epilepsy #ilae #epilepsiaopen #corpuscallosotomy #drugresistantepilepsy #epilepsysurgery #LennoxGastautsyndrome

In GAMT deficiency, epilepsy frequently starts in infancy with fever-related seizures.
doi.org/10.1002/epi4...

#epilepsy #ilae #epilepsiaopen #cerebralcreatinedeficiencysyndrome #creatine #EEG #GAMTD

This study explored whether highly purified Cannabidiol (Epidiolex®) could help manage drug-resistant seizures in people with RTT or CDD.
doi.org/10.1002/epi4...

#epilepsy #ilae #epilepsiaopen #cannabidiol #CDKL5deficiencydisorder #drugresistantepilepsy #Rettsyndrome

The efficacy of perampanel as a second-line therapy to midazolam for refractory SE was evaluated in soman-exposed rats.
doi.org/10.1002/epi4...

#epilepsy #ilae #epilepsiaopen #AMPA #antiseizuremedication #cholinergic #organophosphorusnerveagent #pharmacoresistance

Equitable trial placement is essential to improve global relevance and access to epilepsy research.
doi.org/10.1002/epi4...

#epilepsy #ilae #epilepsiaopen #clinicaltrials #globaldistribution #researchfunding

Anti-seizure efficacy remained the sole predictor of long-term retention.
doi.org/10.1002/epi4...

#epilepsy #ilae #epilepsiaopen #ketogenicdiet #retentionrate

These findings highlight a potential GOF effect for certain DS cases, suggesting that SCB-ASMs may be effective for GOF/mixed DS.
doi.org/10.1002/epi4...

#epilepsy #ilae #epilepsiaopen #Dravetsyndrome #epilepticencephalopathy #gainoffunction #SCN1A #sodium channel

Absence seizures (AS) involve widespread brain networks beyond the cortico-thalamo-cortical loop.
doi.org/10.1002/epi4...

#epilepsy #ilae #epilepsiaopen #basalganglia #cerebellum #idiopathicgeneralizedepilepsies #limbicsystem #spikeandwavedischarges

In this study, we compared RARs in adults with epilepsy and intellectual disability (E + ID) to those from control subjects.
doi.org/10.1002/epi4...

#epilepsy #ilae #epilepsiaopen #actigraphy #DEE #intellectualdisability #restactivityrhythms #sleep

Epilepsia Open - Recently published articles (July 6, 2025)
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#epilepsy #ilae #epilepsiaopen

Interictal thalamic iEEG findings were similar in participants with LGS and IGE except that increased nocturnal delta and daytime beta were observed in the LGS group.
doi.org/10.1002/epi4...

#epilepsy #ilae #epilepsiaopen #idiopathicgeneralizedepilepsy #iEEG #LennoxGastaut #neurostimulation

We present an artificial neural network algorithm for seizure detection in mice and rats.
doi.org/10.1002/epi4...

#epilepsy #ilae #epilepsiaopen #artificialneuralnetwork #featureextraction #intracranialEEG #rodentmodels #seizuredetection

Vigilant cardiac monitoring is recommended in patients with pre-existing cardiac conditions or on antiseizure medications that can affect the cardiac rhythm.
doi.org/10.1002/epi4...

#epilepsy #ilae #epilepsiaopen #asystole #bradyarrhythmia #cardiac #lateonset #syncope #vagalnervestimulation

Of the 99 healthcare professionals (HCPs) surveyed, only 14% had supported individuals on ketogenic diet therapy (KDT) during pregnancy.
doi.org/10.1002/epi4...

#epilepsy #ilae #epilepsiaopen #breastfeeding #ketogenicdiet #Glut1DS #ketones #ketosis #lowglycemicindex #treatment #modifiedAtkinsdiet

Microburst VNS reduces seizure frequency in drug-resistant epilepsy.
doi.org/10.1002/epi4...

#epilepsy #ilae #epilepsiaopen #drugresistantepilepsy #microburstvagusnervestimulation #neuromodulation #restingstatefMRI #thalamus

Perampanel has a superior efficacy and tolerability in the treatment of children with Dravet syndrome as add-on therapy.
doi.org/10.1002/epi4...

#epilepsy #epilepsiaopen #ILAE #China #Dravetsyndrome #efficacy #perampanel #SCN1Agene