@epilepsia-open.bsky.social
The open access journal of the International League against Epilepsy
Two patients had both Lafora disease and distinct rare neurodevelopmental disorders related to pathogenic variants in TRIO and SHANK3.
doi.org/10.1002/epi4...
#epilepsy #ILAE #epilepsiaopen #nextgenerationsequencing #NGS #PhelanMcDermidsyndrome #myoclonusepilepsy #WES #wholegenomesequencing #WGS
Limited data exist on managing pregnancy in Women with Epilepsy (WwE) in rural areas of LMICs.
doi.org/10.1002/epi4...
#epilepsy #ILAE #Epilepsiaopen #antiseizuremedications #preconception #pregnancy
Real-world data are lacking on nonseizure symptom impacts on patients with Dravet (DS) and Lennox–Gastaut syndromes (LGS) and caregivers.
doi.org/10.1002/epi4...
#epilepsy #ILAE #Epilepsiaopen #caregiver #diseaseburden #Dravetsyndrome #LennoxGastautsyndrome #nonseizuresymptoms
PGES occurred in 52% of patients with focal or generalized epilepsy after GTCS.
doi.org/10.1002/epi4...
#epilepsy #ILAE #Epilepsiaopen #corticalsubcorticalparcellation epilepsy #GTCS #PGES #thalamus
Most respondents consider surgery in Lennox–Gastaut Syndrome (LGS) after failure of 3–4 medications and ketogenic diet, later than ILAE-recommended guidelines.
doi.org/10.1002/epi4...
#epilepsy #ILAE #epilepsiaopen #epilepsysurgery #LennoxGastautsyndrome #neuromodulation #surgicaldecisionmaking
SE consists of prolonged seizures that can cause hippocampal injury and respiratory compromise.
doi.org/10.1002/epi4...
#epilepsy #ILAE #epilepsiaopen #benzodiazepines #AMPAreceptors #GABAAreceptors #NMDAreceptors #receptortrafficking
Knowledge about epilepsy is still low among adults in Sudan.
doi.org/10.1002/epi4...
#epilepsy #ILAE #epilepsiaopen #beliefs #misconceptions #practices #Sudan
PMX53 and ACTH analogs show promise; personalized treatments may depend on IESS subtype and sex of the patient.
doi.org/10.1002/epi4...
#epilepsy #ILAE #epilepsiaopen #ACTH #EEG #estradiol #hypothalamus #IESS
Findings underscore the need to better characterize and support patients with diagnostically ambiguous seizure events.
doi.org/10.1002/epi4...
#epilepsy #ILAE #epilepsiaopen #costofillness #healthservicesresearch #healthcareaccess #healthcaredisparities
A total of 70.3% of patients were seizure-free after 12 months on perampanel monotherapy.
doi.org/10.1002/epi4...
#epilepsy #ILAE #epilepsiaopen #monotherapy #perampanel
A cost-effectiveness analysis of initial BRV versus LEV therapy was conducted across the US, Australia, and Japan.
doi.org/10.1002/epi4...
#epilepsy #ILAE #epilepsiaopen #antiseizuremedication #healthcareeconomics #levetiracetam #riskstratification
A two-year terminal seizure freedom was more commonly achieved in patients with GTCA and GGE-NOS, compared to those with JME.
doi.org/10.1002/epi4...
#epilepsy #ILAE #epilepsiaopen #adultonset #antiseizuremedication #geneticgeneralizedepilepsy #seizureoutcome #terminalremission
LOE incidence rises after age 59, a trend seen in Italy's aging population; LOE etiology is heterogeneous and lacks a uniform definition.
doi.org/10.1002/epi4...
#epilepsy #ILAE #epilepsiaopen #Alzheimersdisease #antiseizuremedications #dementia #LOE
This was a small, single-center retrospective cohort study evaluating the use of ambulatory EEG monitoring in patients with possible absence seizures.
doi.org/10.1002/epi4...
#epilepsy #ILAE #epilepsiaopen #seizurecounts #seizurediaries #therapymanagement #wearables
Barriers to SUDEP talks include time limits, fear of distress, and doubts about patient understanding.
doi.org/10.1002/epi4...
#epilepsy #ILAE #epilepsiaopen #mortality #seizures #SUDEP #SUDEPcommunication
Patients with university qualifications are more likely to be aware of epilepsy surgery as a treatment option.
doi.org/10.1002/epi4...
#epilepsy #ILAE #epilepsiaopen #Asia #barriers #drugresistant #patient #surgery
Parents of youth with epilepsy and mild or severe cognitive issues reported less transition support from healthcare providers.
doi.org/10.1002/epi4...
#Epilepsy #ILAE #Epilepsiaopen #cognitivedeficit #selfmanagement #youth
BRV as an add-on therapy significantly reduces seizure frequency in patients with focal onset seizures.
doi.org/10.1002/epi4...
#epilepsy #ILAE #epilepsiaopen #antiseizuremedication #brivaracetam #combination #drugtherapy #focalonsetseizures #seizures
Neuropsychological assessment can aid stereo-EEG planning and support individualized counseling of cognitive and psychological outcomes.
doi.org/10.1002/epi4...
#epilepsy #ILAE #epilepsiaopen #cognitivemapping #drugresistantepilepsy #neuropsychological #assessment #rehabilitation #RFTHC #SEEG
Drug-resistant and brain MRI-negative neonatal epilepsies have a strong monogenic component and are associated with a poor long-term neurodevelopmental outcome.
doi.org/10.1002/epi4...
#epilepsy #ILAE #epilepsiaopen #DEE #epilepsysyndromes #KCNQ2 #neonatalonsetepilepsy #prognosis #factors
New in Epilepsia Open – September 14, 2025
mailchi.mp/ilae/epileps...
Subscribe - eepurl.com/iLSrNc
#epilepsy #epilepsiaopen #ILAE #EpilepsyResearch #NewInEpilepsy #JustPublished #LatestResearch
This study assessed neurologists' practices and barriers to epilepsy genetic testing/counseling compared to guidelines published in 2022.
doi.org/10.1002/epi4...
#epilepsy #ILAE #epilepsiaopen #adultneurologists #bestpractices #genomics #unexplainedepilepsy
nNOS deficiency in adult-born DGCs increases dendritic length, branch complexity, and spine density.
doi.org/10.1002/epi4...
#epilepsy #ILAE #epilepsiaopen #dentategranulecells #neuronalnitricoxidesynthase #pilocarpine #temporallobeepilepsy
Low Awareness of Epilepsy Surgery: Less than half of included epilepsy patients in Serbia are familiar with epilepsy surgery (ES) for drug-resistant epilepsy (DRE).
doi.org/10.1002/epi4...
#epilepsy #ilae #epilepsiaopen #antiseizuremedications #education #epilepsysurgery #media
Internal laboratory data relevant to VUS is frequently omitted from clinical reports.
doi.org/10.1002/epi4...
#epilepsy #ilae #epilepsiaopen #Documentation #genetics #laboratorycorrespondence #pediatrics
SARS-CoV-2 infection causes long-term neurological and psychiatric symptoms in PwE.
doi.org/10.1002/epi4...
#epilepsy #ILAE #epilepsiaopen #healthcare #intervention #postacutesequelae #COVID19 #SARSCoV2
Harmonized preclinical SUDEP research with CDEs may improve data transparency and scientific rigor.
doi.org/10.1002/epi4...
#epilepsy #ILAE #epilepsiaopen #additionalphenotypes #casereportform #commondataelement #electrophysiology #neuroimaging #neurological #physiology #therapeutics #translation
General mental ability (g) is lower in JME than control participants.
doi.org/10.1002/epi4...
#epilepsy #epilesiaopen #ilae #cognitivereserve #generalmentalability #JuvenileMyoclonicEpilepsy #morphology #MRI #neuropsychology
Following febrile status epilepticus (FSE), approximately 10% of infants had unilateral hippocampal T2 hyperintensity on MRI.
doi.org/10.1002/epi4...
#epilepsy #ILAE #epilepsiaopen #EEG #febrileseizures #hippocampus #MRI #sclerosis #temporallobe
DR-JME patients show altered brain dynamics and cognitive deficits, highlighting the need for early detection and targeted therapies.
doi.org/10.1002/epi4...
#epilepsy #ilae #epilepsiaopen #drugresistant #eventrelatedpotential #excitatoryinhibitoryimbalance #juvenilemyoclonicepilepsy #visualGoNoGo
