Chrysante Iliakis

An aging bone marrow exacerbates lung fibrosis by fueling profibrotic macrophage persistence Hematopoietic aging drives lung fibrosis and profibrotic macrophage influx, stalling their maturation via reduced Treg-derived IL-10.

1/ Excited to share my first-ever first-author paper out now in Science Immunology! from @knapplab.bsky.social and co-supervised by @miershawig.bsky.social
We show that hematopoietic aging, independent of lung tissue aging, is sufficient to exacerbate fibrosis.
🔗 www.science.org/doi/10.1126/...

28.03.2025 19:10 — 👍 35    🔁 9    💬 3    📌 2

Congratulations Asma!!🥳

29.03.2025 17:30 — 👍 0    🔁 0    💬 1    📌 0

Lab’s latest: (mouse) mums grow their guts during pregnancy and lactation: www.cell.com/cell/fulltex...

19.03.2025 17:31 — 👍 170    🔁 65    💬 14    📌 6

Review
Tissue-resident immune cells: from defining characteristics to roles in diseases
www.nature.com/articles/s41...

19.01.2025 03:18 — 👍 51    🔁 20    💬 1    📌 0

Intestinal E. coli-produced yersiniabactin promotes profibrotic macrophages in Crohn’s disease Inflammatory bowel disease (IBD)-associated fibrosis causes significant morbidity. Mechanisms are poorly understood but implicate the microbiota, espe…

#WeekendRead! Ahn, Arthur &co show @CellHost&Microbe that pathogenic E. coli produce a metallophore that sequesters zinc in macrophages, stabilizing HIF1a & driving fibrosis in #IBD mouse models and Crohn Disease patients! www.sciencedirect.com/science/arti...

11.01.2025 15:41 — 👍 25    🔁 9    💬 1    📌 1

Congrats Marta!🥳🥳

24.11.2024 15:47 — 👍 1    🔁 0    💬 0    📌 0

How do NKT cells control epithelial cell biology and function in the small intestine ?

Thrilled to share my PhD work investigating the cytokine driven crosstalk between NKT cells and epithelial cells in the gut @barrallab.bsky.social

24.11.2024 15:42 — 👍 16    🔁 5    💬 1    📌 0