Darko Barisic

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Lab night out on Broadway! 🎭 A well-earned pause from experiments. 🧬

So fascinating.

Huge congratulations to my postdoc Jiali Yu 👏 who has been awarded a fellowship from the National Cancer Center. She’ll be investigating how chromatin remodelers contribute to the onset and progression of blood cancers. So proud and excited for what’s ahead. 🚀

Awesome story! 🙌

Fantastic work! 🙌

Great work! 🙌

This is big! 🙌

Fantastic! 🙌

Huge congrats to *Ari Melnick* on being appointed the Director of the Josep Carreras Leukemia Research Institute in Barcelona! 🙌 👏

The SWI/SNF PBAF complex facilitates REST occupancy at repressive chromatin By mapping SWI/SNF complex subfamilies in the melanocytic lineage, Grossi and Nguyen et al. find that PBAF-only sites harbor PRC1/2 modifications and the repressive transcription factor REST. PBAF is ...

🎉 Excited to share my postdoc work in the Bernstein lab now online @cp-molcell.bsky.social!
🔎We explored the unique functions of the SWI/SNF PBAF complex and its relationship with TFs, and unveiled a PBAF/REST-controlled neuronal-like signature with potential implications in #melanoma brain mets🧬

🚨Our new prepint 🚨
▶️ When a bromodomain goes rogue

Rsc1 bromodomain 2 doesn’t bind acetyl-lysines.
It grabs DNA instead — and yeast cells die 💀 without it.

Plot twist? Read our preprint:
👉 www.biorxiv.org/content/10.1...
#chromatin #bromodrama #DNAlover

And a 🧵👇 1/5

Very exciting!

Absolutely fantastic work from the magnificent @davidlabmsk.bsky.social lab! Incredible science and amazing out-of-the-box approach. Congrats to all the authors and highly recommend the read. 🙌

Nearly every medicine we benefit from started with NIH-funded research. Early discovery work starts in academia.

Immunotherapies?
Gene therapy for rare diseases?
Alzheimer’s and Parkinson’s medicines?
Vaccines?
Novel cancer treatments?
Psychiatric medicines?

You betcha.

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Incredible work! 🙌

The Others!

Multiplex generation and single-cell analysis of structural variants in mammalian genomes Studying the functional consequences of structural variants (SVs) in mammalian genomes is challenging because (i) SVs arise much less commonly than single-nucleotide variants or small indels and (ii) ...

Impressed by Genome-Shuffle-seq. 🔀 “Multiplex generation and single-cell analysis of structural variants in mammalian genomes”.

www.science.org/doi/10.1126/...

I laughed out loud!

Wait until you find out about The Poisonwood Bible! :-)

We should preface all findings with this. So the public understands how NIH funding actually drives science.

Long-read sequencing just got an upgrade. 📢 Genome, methylome, epigenome & transcriptome in one go—haplotype-resolved & at single-molecule resolution. 🔥

Worth the read for someone who doesn’t have to be convinced?

Multiscale footprints reveal the organization of cis-regulatory elements - Nature We developed PRINT, a computational method that identifies footprints of DNA–protein interactions from bulk and single-cell chromatin accessibility data across multiple scales of protein size.

PRINT is finally out. 🖨️ Highly recommend this paper! Congrats to Buenrostro group and all the authors. 🙌 “Multiscale footprints reveal the organization of cis-regulatory elements.”

www.nature.com/articles/s41...

Single-cell mapping of regulatory DNA:Protein interactions Gene expression is coordinated by a multitude of transcription factors (TFs), whose binding to the genome is directed through multiple interconnected epigenetic signals, including chromatin accessibil...

🧬 We’re excited to introduce D&D-seq, a single-cell technology that maps DNA:Protein interactions through molecular footprinting. Check it out here: biorxiv.org/content/10.1... #Genomics #Epigenetics

#ASH2024 Highly recommend this place for lunch. Also, highly recommend the company @jchellmuth.bsky.social!

go.bsky.app/KbjoCuC

Done. :-)

Done.

Closest I know of is lymphoma research from @darkobar.bsky.social:

bsky.app/starter-pack...

Great morning session with Panagiotis Ntziachristos on Lymphoid Oncogenesis – Molecular Insights Into Lymphoma and CLL. #ASH2024