@NicoliLab

Degeneration and Impaired Resilience of Skull Bone and Hematopoietic Bone Marrow Bone marrow health is central to transplantations, blood formation, and cancer progression. However, the bone marrow niche deteriorates with age, impairing haematopoietic stem cell function. Contrary ...

A recent preprint (Yang et al., doi.org/10.1101/2025...) challenges an article from my lab published in 2024 (Koh et al. 2024, PMID: 39537918). We strongly dispute their claims (please see our comment on bioRXiv).

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Identifying the cellular and molecular factors that contribute to tissue mechanical strength is a critical step for developing regenerative medicine approaches. Thank you to all who contributed to this work!

We found that the ECM composition underlying the stem cells affects wound healing speed!

We define the extracellular matrix composition in the developing zebrafish fin fold, and how stem cells regulate adhesion molecule expression in the superficial cell layer above.

Unlocking the Skin’s Natural Healing Power Researchers show that embryonic skin stem cells rely on a specialized mechanism to resist injury. The findings could lead to new strategies for repairing wounds

So excited to announce lab alumni Dr. Helen Mengze He and Liana Boraas work at @yalecvrc.bsky.social in collaboration with the Kaelyn Sumigray lab @yaleschoolofmed.bsky.social is published today in @natcomms.nature.com and highlighted in Yale News! medicine.yale.edu/news-article...

OMG 😱 a true game changer for biology! Menstruation is a natural miracle of tissue regeneration. Amazing biology to come!

First approved drug for mitochondrial disease could pave way for more treatments Researchers are testing multiple treatments for the rare genetic conditions

Mitochondrial diseases have seemed intractable, but last month the Food and Drug Administration OK’d the first treatment targeting a mitochondrial flaw. https://scim.ag/4q3Ymxz

New preprint from the lab! We discovered a transient fluidization in the basal region of human forebrains by tracking microdroplets in cerebral organoids.This “basal fluidization”, absent in gorilla and mouse, may contribute to greater surface expansion in human forebrains
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doi.org/10.1101/2025...

Sequencing-free whole-genome spatial transcriptomics at single-molecule resolution RAEFISH delivers whole-transcriptome (>20,000 genes) imaging at single-molecule resolution in cells and tissues and enables direct gRNA detection for high-content, image-based CRISPR screens.

🔥Sequencing-free whole-genome spatial transcriptomics at single-molecule resolution

www.cell.com/cell/fulltex...

😍😍👏🏼👏🏼

Illustration of the human circulatory system with red arteries and veins shown against a semi-transparent blue human torso. An aneurysm is visible on the aorta in the abdomen.

Our researcher communities have a new space just for cardiovascular researchers and clinicians. Dive into the ‘Aortic Aneurysm and Dissection Management’ hub, where you can explore new research, join the discussion and connect with peers from the field. go.nature.com/4gPRT55 #Academicsky

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Faculty positions in animal morphogenesis that may be filled at the Assistant or Associate Professor level in one of my favorite Departments" Cell and Systems Biology at the University of Toronto. 1/n
jobs.utoronto.ca/job/Toronto-...
jobs.utoronto.ca/job/Toronto-...

[Job]
PhD Position in Neuroscience, Ting-Feng Lin Lab, Utrecht University, Utrecht, Netherlands

#zebrafish

Mechanochemical waves in focal adhesions during cell migration Traction force and FAK signaling exhibit oscillatory temporal coupling in adhesive structures.

Garcia Lab did it again! Such a fantastic read if you are interested in FAs mechanics and biology. Congratulations to @garcialabgt.bsky.social

Out @natcomms.nature.com:
our work on how the ❤️-supporting pericardium forms & acts in pediatric heart conditions.🎈🫀

Expanding our preprint & with our first HCR (thx to @thelovelylab.bsky.social!).

Congrats all! #devbio #zebrafish #CHD @cupediatrics.bsky.social @cudevbio.bsky.social
rdcu.be/eIJm5

Optimality as a framework for understanding developmental robustness Embryo growth, morphogenesis, and patterning are complex processes that coordinate between cellular dynamics, fate specification, and multiscale physical forces. Understanding how robustness in embryo development is achieved despite inherent heterogeneities in gene expression, cell properties, and tissue growth is a fundamental question. Although various feedback between gene expression, signaling, and cell and tissue mechanics have been uncovered to confer robustness on developmental systems, measuring variability and robustness from a quantitative perspective often remains challenging. Furthermore, cell fate plasticity, a key mechanism that can confer robustness, is lacking in many developing tissues. This review highlights how recent technological and conceptual advances in quantitative approaches to biology help to overcome these bottlenecks, with a particular focus on how mechanochemical feedback, or alternatively, selectively tuned control parameters, ensure developmental robustness.

Optimality as a framework for understanding developmental robustness

Collective homeostasis of condensation-prone proteins via their mRNAs - Nature The authors discover a homeostatic process termed interstasis, in which an increased concentration of proteins within RNA–protein condensates induces the sequestration of their own mRNAs.

Nature research paper: Collective homeostasis of condensation-prone proteins via their mRNAs

go.nature.com/4pJMocs

Regionalized & Sex-dependent scRNAseq of 🐭Aorta

Carotid
Aortic Arch
Descending Thoracic
Abdominal Aortic #SmoothMuscleCell

Arch
#SecondHeartField vs #NeuralCrest SMC

339 Regional SMC mRNA features ➡️ cardiovascular trait GWAS

#AortaEd
#NatCardiovascRes 2025
www.nature.com/articles/s44...

Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.

How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇

[Job]
Aquatics Manager, Howard Hughes Medical Institute - Janelia Research Campus, Ashburn, VA

#zebrafish

Tavano, S., Brückner, D. B., ... & Heisenberg, C. P. (2025). BMP-dependent patterning of ectoderm tissue material properties modulates lateral mesendoderm cell migration during early zebrafish gastrulation. Cell Reports, #EpithelialMechanics doi.org/10.1016/j.ce...

New vascular seminars coming up @evborg.bsky.social

New perspective by @maikbischoff.bsky.social & @mayorlab.bsky.social about how mesenchymal cells use contact-dependent rules to generate swarm-like behaviors, patterns & organ forms. rupress.org/jcb/article/...

#CellBio #CellMigration #Morphogenesis #Development #Science

Mechanical forces stimulate Golgi export Human cells face a wide range of external mechanical stimuli that vary with cell type, state, and pathological conditions. The rapidly growing field of mechanobiology investigates how cells sense and ...

🧵 I've been meaning to write a #Skytorial on our recently posted prepring in which we show evidence that the Golgi 🥞 is a mechanoresponsive organelle. Extracellular mechanical forces also tune Golgi export capacity! 👉 www.biorxiv.org/content/10.1...

Great story in this issue @nature.com. Shows that the regulatory region controlling digit devt in vertebrates was not copy-pasted directly from fin development. So, the "fin-to-limb transition" in vertebrate evolution isn't as clear cut as originally thought.🧪👏👇 (lovely summary btw).

Years of hits to the head prime the brain for decline Repetitive head impacts trigger neuronal loss and disrupt blood vessels and immune cells long before the accumulation of neurotoxic tau protein.

Repetitive head impacts trigger neuronal loss and disrupt blood vessels and immune cells long before the accumulation of neurotoxic tau protein

go.nature.com/4n8UwRQ

Biomechanics influence morphogenesis of the lung. Really cool paper by Shelby and Victor at UT Southwestern and UTD!

👋Our September issue's out!
Cover: Oncofusion condensates

👉🏼Review on #hematopoietic #aging
🔬 #StemCells #trophectoderm #immunotherapy #fibrosis #cancer #necroptosis #chromatin #mitosis #mitophagy #ProteinFolding #BiomolecularCondensates #organelles & more!
www.nature.com/ncb/volumes/...

Sex differences in tissue-specific immunity and immunology Biological sex exerts a substantial influence on the immune system and immune-related diseases. Males are more susceptible to the acute effects of viral disease and certain cancers, whereas females ex...

Researchers in a recent #ScienceReview examine the influence that biological sex exerts on the immune system and immune-related diseases.

Learn more: https://scim.ag/4ln58Le

Computational image analyst (m/f/d) The Max Planck Institute for Molecular Biomedicine in Münster, Germany, has an opening for a

My lab @mpi-muenster.bsky.social is looking for a computational biologist with a passion for imaging and spatial biology. A staff scientist position with long-term perspective! Apply and spread the word 🙏 jobs.mpi-muenster.mpg.de/jobposting/0...