@NicoliLab

Can creativity in science be learnt? These researchers think so Time pressure gets in the way of ideas. Developing ‘creative oases’ and small grants for risky ideas can encourage innovative thinking in science.

Time pressure gets in the way of ideas. Developing ‘creative oases’ and small grants for risky ideas can encourage innovative thinking in science

go.nature.com/459cPQz

Super cool story and a super cool protein. Somehow conserved across almost all metazoans (and even before) but unlike anything other protein in organization and function. WEIRD!!

Exploring the Uncharted Waters of Endothelial Tip Cell Migration: A Story of Aquaporins, Hydrostatic Pressure, and Angiogenesis - the Node Behind the Paper Story of “Combined forces of hydrostatic pressure and actin polymerisation drive endothelial tip cell migration and sprouting angiogenesis”.

Thank you @the-node.bsky.social‬ for inviting me to write a 'Behind the Story' piece on our recent study!

Exploring the Uncharted Waters of Endothelial Tip Cell Migration: A Story of Aquaporins, Hydrostatic Pressure, and Angiogenesis thenode.biologists.com/exploring-th...

The vascular contribution to cognitive decline in ageing and dementia - Nature Reviews Neuroscience Growing evidence suggests that reduced cerebral blood flow contributes to cognitive decline in ageing and dementia. Attwell and colleagues discuss the underlying mechanisms and functional consequences...

Delighted to share our latest review in Nature Reviews Neuroscience!
We examine the growing evidence that vascular dysfunction plays a key role in cognitive decline in ageing and dementia, and argue that preserving/restoring CBF should be central to future therapies.
www.nature.com/articles/s41...

Congratulations! This is a masterpiece!👏🏼👏🏼👏🏼

Congratulations!

Plasmodium falciparum egress disrupts endothelial junctions and activates JAK-STAT signaling in a microvascular 3D blood-brain barrier model Nature Communications - Here the authors show that Plasmodium falciparum egress products disrupt endothelial barrier and activate JAK-STAT and interferon type response in a 3D blood-brain barrier...

We are happy to show one ourt first exciting papers. We have developed a blood-brain barrier model to study the disruptive effects caused by the malaria parasite, Plasmodium falciparum.

First, congratulations to the fearless @liviapiatti.bsky.social and @alinabatzi.bsky.social

rdcu.be/ezBl7

📰Latest from our lab (Open Access)!

Brain Capillary Ion Channels: Physiology and Channelopathies

This review attempts to concisely cover a fast-evolving research field on channels in🧠capillaries
@apspublications.bsky.social

journals.physiology.org/doi/abs/10.1...

Metal-induced nanoscale clusterization initiates protein liquid-liquid phase separation Xiang et al. present a precise approach to investigate the assembly mechanism underlying protein liquid-liquid phase separation. The findings demonstrate that multivalent weak metal coordination induces clusterization of nanoscale seeds, triggering protein condensation. These insights advance the understanding of how intermolecular interactions influence the early stages of protein condensation.

Metal-induced nanoscale clusterization initiates protein liquid-liquid phase separation

Crossover patterning through condensation and coarsening of pro-crossover factors - Nature Cell Biology Zhang et al. provide evidence that, during meiosis, recombination proteins assemble into active droplets, the coarsening of which partially explains the phenomenon of crossover interference.

🍹Zhang et al. provide evidence that, during #meiosis, recombination proteins assemble into active droplets, the coarsening of which partially explains the phenomenon of crossover interference. #PhaseSeparation
👉https://rdcu.be/ezdVj
bit.ly/3IXNj8a

YAP maintains the dynamics of TDP-43 condensates and antagonizes TDP-43 pathological aggregates - Nature Cell Biology Zhang et al. show that YAP binds to TDP-43 to promote TDP-43 multimerization and phase separation. YAP and TDP-43 may co-localize in multiple cell types in oxidative stress and in brain samples from i...

🍹Zhang et al. show that YAP binds to TDP-43 to promote TDP-43 multimerization and #PhaseSeparation. YAP and TDP-43 may co-localize in multiple cell types in oxidative stress and in brain samples from individuals with #AmyotrophicLateralSclerosis
👉https://rdcu.be/ezd0q
bit.ly/4lYo1oO

Global & Arteriole-capillary transition zone #NeuroVascularCoupling imaged by #UltrasoundLocalizationMicroscopy😆

Adult endothelial Eng KO🐭
👉Arteriole dilation+tortuosity
👉Ensheath/Mesh Pericyte soma rounding
👉⏬Sensory🧠flow

@mickaeltanter.bsky.social #NatBME ‬2025
link.springer.com/article/10.1...

🍹Li et al. uncover a lysosomal surveillance response whereby intestinal lumen deacidification induces a transcriptional program that boosts lysosomal activity and improves protein aggregate clearance in multiple worm disease models, extending #healthspan.
#lysosome
bit.ly/46G38dx

Quality assessment of RNA 3D structure models using deep learning and intermediate 2D maps https://www.biorxiv.org/content/10.1101/2025.07.25.666746v1

SMART tool builds proteins on cell surfaces Researchers can target effector proteins to cells on the basis of which molecules those cells express.

Scientists have created a tool that manufactures working proteins directly on the surfaces of cells

go.nature.com/3IMPyv0

The G3BP1 RNP complex at focal adhesion tunes cell migration Ribonucleoprotein (RNP) complexes can form multiple mesoscale assemblies, including stress granules (SGs). However, the function and regulation of the soluble RNP complexes are not fully understood. A...

www.cell.com/trends/cell-...

Cell's sugar coating mapped at below-nanometre resolution Super-resolution technique works with off-the-shelf optical microscopes.

Scientists have mapped individual sugar molecules on the surface of cells at a resolution once thought to be impossible for light microscopes

go.nature.com/4l2wVjS

G3BP1 ribonucleoprotein complexes regulate focal adhesion protein mobility and cell migration Boraas et al. identify that mRNAs and the stress granule RNA-binding protein G3BP1 form ribonucleoprotein (RNP) complexes at FAs. These RNPs regulate FA protein mobility and cell migration under norma...

Check out how mRNA can influence cell motility! See how here: www.cell.com/cell-reports.... Thanks for the shout-out Yale News and @cp-trendscellbio.bsky.social!

news.yale.edu/2025/02/13/f...

www.cell.com/trends/cell-...

Protein Kinase C promotes #peroxisome biogenesis & peroxisome–endoplasmic reticulum interaction, say Anya Borisyuk, Daniel Kaganovich, Triana Amen (EPFL, @unisouthampton.bsky.social) et al: rupress.org/jcb/article/...

▶️ Charlotte Howman provides a video summary: youtu.be/HAYOi4GU31E
#ER_literature

🗞️Do you want to meet and chat with our stem cell editor @slefkopoulos.bsky.social about your work for our journal? He will be there!
Register now for the FEBS Workshop on Aging in Hematopoiesis that will take place in Crete on October 20-24. aginginhematopoiesis2025.febsevents.org

Epithelial cells provide immunocompetence to the early embryo for bacterial clearance Roncero-Carol et al. show that early embryos eliminate bacteria via phagocytosis by epithelial cells. Quantitative live imaging across scales in zebrafish embryos reveals an epithelial immune program ...

Epithelial cells provide immunocompetence to the early embryo for bacterial clearance: Cell Host & Microbe www.cell.com/cell-host-mi... 🧪

RNA can control cell migration by acting at focal adhesions - Scientific editing and writing experts - Life Science Editors Scientific editing and writing experts for manuscripts and grants

RNA can control cell migration by acting at focal adhesions www.lifescienceeditors.com/2025/06/24/r...

Pics from the Vascular Biomechanics GRC 2025 Ventura, pushing the envelope in bioengineering, human vascular imaging, and new ideas to study blood vessel diseases. Congrats to organizers Kim Van Der Heiden, Tzung Hsiai, Eno Ebong, and Paul Evans!🧠❤️👏🏼

A hypoxia-responsive tRNA-derived small RNA confers renal protection through RNA autophagy Transfer RNA-derived small RNAs (tsRNAs, or tDRs) perform a range of cellular functions. Here, we showed that a hypoxia-induced tDR, derived from the 3′ end of tRNA-Asp-GTC (tRNA-Asp-GTC-3′tDR), activ...

In First Release @science.org this week
A hypoxia-responsive tRNA-derived small RNA confers renal protection through RNA autophagy | Science www.science.org/doi/10.1126/...

Grateful for inspiring conversations with colleagues, fantastic leadership with Chair Karen K. Hirschi, and standout talks from @yalecvrc.bsky.social Kathleen Martin @kathleenmartin.bsky.social and our very own Ivan (Fan) Xia @ivanfxia.bsky.social .

We had an amazing time at the Vascular Cell Biology GRC last week in Maine! Looking forward to the next VCB GRC in sunny LA—January 2027!