Thiago J Borges, PhD

A brief T–cell–mediated rejection occurred early, likely due to residual lymph node immunity, but was successfully treated. No antibody-mediated rejection was seen.

🐷➡️🧬 In the first pig-to-human kidney transplant, a multiomics approach demonstrated that persistent innate immune activation (monocytes/macrophages) remains a key barrier. Better control of innate immunity will be critical for future success.

Read more at: www.nature.com/articles/s41...

Thanks for highlighting our work!

💡 Takeaway: Innate immune checkpoints like Siglec-E/7/9 are emerging as crucial regulators of transplant rejection. 4/4

📄 Newsroom @mgbresearch.bsky.social: www.massgeneralbrigham.org/en/about/new...

✅ Blocking NF-κB or TNF-α in Siglec–E–deficient models restores graft survival.

✅ In humans, higher expression of SIGLEC7/9 (homologs of Siglec-E) is linked to better allograft outcomes —highlighting their potential as biomarkers or therapeutic targets. 3/4

✅ Siglec-E suppresses dendritic cell activation, limiting NF-κB signaling and TNF-α production.

✅ Loss of Siglec-E accelerates rejection in murine heart, kidney, and skin transplants through heightened T cell–mediated immunity. 2/4

The inhibitory receptor Siglec-E controls antigen-presenting cell activation and T cell–mediated transplant rejection Siglec-E negatively regulates innate immune responses and acute T cell–mediated transplant rejection in mice, offering a potential therapeutic target.

🚨 Our new study in @SciTranslMed identified the inhibitory receptor Siglec-E as a critical brake on dendritic cell activation and T cell–mediated transplant rejection. 1/4
www.science.org/doi/10.1126/...

🚨 Great Opportunity! 🚨

The Riella Lab, at the Mass General Hospital, is seeking a Postdoc in Transplant Immunology with expertise in Microsurgery.

📍 Apply now! #Postdoc #Microsurgery #TransplantResearch

Xenotransplantation of a Porcine Kidney for End-Stage Kidney Disease | NEJM Xenotransplantation offers a potential solution to the organ shortage crisis. A 62-year-old hemodialysis-dependent man with long-standing diabetes, advanced vasculopathy, and marked dialysis-access...

Presented at #ISNWCN:

A new report describes the transplantation of a gene-edited porcine kidney in a hemodialysis-dependent man with long-standing diabetes, advanced vasculopathy, and marked dialysis-access challenges. Read the full report: nej.md/3Esayoz

@theisn.org

Cardiac allograft tolerance can be achieved in nonhuman primates by donor bone marrow and kidney cotransplantation Combining transient mixed chimerism with kidney cotransplantation achieves heart allograft tolerance in nonhuman primates.

Cardiac allograft tolerance can be achieved in nonhuman primates by donor bone marrow and kidney cotransplantation | Science Translational Medicine www.science.org/doi/10.1126/...

Review
@sciimmunology.bsky.social
DC–T cell interactions during priming influence CD8+ T cell fate, and DCs subsequently sustain T cell responses against cancer
science.org/doi/10.1126/...

Functional differences between rodent and human PD-1 linked to evolutionary divergence A highly conserved motif in human PD-1 but absent in rodent PD-1 is linked to differential inhibitory activity.

A highly conserved motif in human PD-1 but absent in rodent PD-1 is linked to differential inhibitory activity
@scienceimmuno.bsky.social @enfuhui.bsky.social
www.science.org/doi/10.1126/...

Dysregulated Treg repair responses lead to chronic rejection after heart transplantation
www.jci.org/articles/vie...

Great opportunity! I learned a lot from the experience
👇🏼👇🏼👇🏼👇🏼

The hypoimmune mouse (MHC-deletion, CD47 overexpression) and all of its organs are completely invisible to allogeneic immune cells
www.cell.com/iscience/ful...