Wright Laboratory

Computational and Theoretical Biology As we navigate the era of big data in biological research, advanced computational techniques, such as mathematical models and machine learning algorithms, are ...

Our EvoWeaver work is now included on the Computational and Theoretical Biology focus page of Nature Communications! The page highlights recent work that reports methodological advances in computational biology. www.nature.com/collections/...

EvoWeaver: large-scale prediction of gene functional associations from coevolutionary signals - Nature Communications Despite having structures for most proteins, we still do not know their function. Here, authors introduce EvoWeaver, a de novo method to identify genes working together using evolutionary information....

Proud to announce a new publication from the lab: EvoWeaver: large-scale prediction of gene functional associations from coevolutionary signals
www.nature.com/articles/s41...

Why work on differences between homology and analogy? Bc protein structure search is super popular. We've always wondered whether some structure matches arise from convergent evolution. Now we know the answer – a resounding yes! This has major implications for the use of protein structure search.

Tandem Repeats Provide Evidence for Convergent Evolution to Similar Protein Structures Abstract. Homology is a key concept underpinning the comparison of sequences across organisms. Sequence-level homology is based on a statistical framework

🧪🧬🖥️ new paper: Tandem Repeats Provide Evidence for Convergent Evolution to Similar Protein Structures (doi.org/10.1093/gbe/...). You can also see the video explainer here: wrightlabscience.com/publications

We'd love to be included!

Nishant just came back from the EMSL at PNNL! wrightlabscience.com/news#oct2024

Vancomycin may not be able to treat MRSA infections for long Researchers have found Staphylococcus aureus can adapt to vancomycin while overcoming its fitness cost, threatening the long-term use of vancomycin in the clinic.

One of our recently published articles has gotten traction in the popular press: www.thehindu.com/sci-tech/sci...

New Paper Alert! VRSA can overcome the cost of antibiotic resistance and may threaten vancomycin's clinical durability, from our Master's student (and his second paper published this month!). www.wrightlabscience.com/publications

Infographic with topic headings about "Challenges Leveraging EHR for ML", Resistant Pathogen Prediction, Predicting Resistance to Multiple Antibiotics, Aiding Antimicrobial Stewardship." Read paper here: https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiae348/7712688

One of the M.S. students got 2 papers accepted within days of each other! Here is one of them about #MachineLearning, #ElectronicHealthRecord Data, and #AntibioticResistance. #Bioinformatics has such a great place in our evolving healthcare landscape. 🧪 🧬🖥️

We are at #ISMB2024! Come say hi! (I'm probably the tallest person at the conference)

Time to update to decipher v3.0 new search functions that are versatile, fast and in R ultra-fast pairwise alignment sequence databases now work wiht multiple flavors of SQL avaliable from bioconductor

Updates to DECIPHER! It's now DECIPHERv3, with some cool updates! See wrightlabscience.com/news #bioinformatics #bioconductor #Genomics #biotechnology #R

Post it with text: Aidan was awarded grant funding by the R Consortium's Infrastructure Steering Committee. This award will fund critical work to the Biostrings package for R, one of the foundational packages in the R bioinformatics community. This work will begin in June and take place over a year. By the end, he's expected to be the primary maintainer of Biostrings. Congrats Aidan!

One of the lab members was awarded funding to enhance and maintain #R #Biostrings. We're looking forward to seeing what he can do for the #bioinformatics community.

Cool new paper released from the lab: Many purported pseudogenes in bacterial genomes are bona fide genes! wrightlabscience.com/publications

Wright Lab Recrutiting for Postdoctoral researchers. 3-4 year funded positions in informatics/genomics/EHR mining, antibiotic resistance, with access to clinical EHR data warehouse. Apply to eswright@pitt.edu, start in Sept, due April 29th.

Hi All: We're looking for Post-Docs for our soggy lab for September. You don't have to already be a bioinformatician, as we are willing to train. We're especially interested in solving antibiotic resistance. Pls reach out w/ questions and share. We'd love to fill this position (we have 2). 🧪🖥️🧬

Graphic Reads GLBion 13-16May 2024 Call for Abstracts, Due March 4 Scalable Analysis for Big Biological Data Hosted by wrightlabscience.com

GLBio24 is in Pittsburgh this year! Submissions are open! Submit to our "Big Biological Data" Special Session! 🧪

5 conferences attended, 10 manuscripts submitted, 2 papers published, 7 classes taken, 1045 years of computing on open science grid.

Now that Spotify Wrapped has wrapped. Let's check out the Wright Lab Year In Review! 🧪

Turns out that popular AI suggests us not once, but 3 times for the same query on sequence alignments. www.wrightlabscience.com/index.html

We're the Wright Lab at the University of Pittsburgh School of Medicine. We do evolution of antibiotic resistance in a 'soggy' (both dry and wet lab work) lab. Our under-construction website: www.wrightlabscience.com/p/index.html. We also have available T15 funding!

Recruitment flyer for dbmi.pitt.edu Image is text describing phd in biomedical informatics

Our department is recruiting PhD students for the 2024 cohort! Come work with us in biomedical informatics. Our lab works on solutions to antibiotic resistance using computational methods. 🧪🧫🩺

Hi! can we be added to the what's science feed/bioinformatics? @danirabaiotti.bsky.social (Also, thanks for curating!) 🧪. 🖥️ 🧬

Recruitment flyer for dbmi.pitt.edu

Are you an undergrad looking for a grad program in the bioinformatics space? Are you interested in new, evolving problems in antibiotic resistance? We have funding. Come work with us! 🧪