@ped-neph.bsky.social
Original clinical research and reviews on all aspects of acute and chronic diseases affecting kidney function in children. Official journal of IPNA.
Oral immunoglobulin as a potential option for chronic norovirus diarrhea in pediatric kidney transplant recipients
Pediatric solid organ transplantation recipients are at increased risk of diarrhea due to immunosuppression & epidemiological risk factors. Read this Research Letter re oral immunoglobulin for norovirus diarrhea in pediatric kidney transplant recipients.
link.springer.com/article/10.1...
Genetic causes of nephrolithiasis and nephrocalcinosis in a pediatric population in Saudi Arabia
Nephrolithiasis (NL) & nephrocalcinosis (NC) are common pediatric kidney conditions globally. Read this Original Article on genetic causes of NL & NC in a pediatric population in Saudi Arabia. Open Access
link.springer.com/article/10.1...
Rituximab in pediatric refractory nephrotic syndrome: a systematic review and meta-analysis evaluating therapeutic efficacy and adverse event profiles
Rituximab is a therapeutic option in children w/refractory nephrotic syndrome (RNS), but the efficacy & safety of rituximab treatment remain unclear. Read this Systematic Review /Meta-analysis of rituximab efficacy in pediatric RNS. Open Access
link.springer.com/article/10.1...
Thirst, sodium, and the hospitalized child: rethinking hypernatremia
Hypernatremia is a challenging condition. A rapid increase in blood sodium can draw water out of brain cells. A rapid correction to a slow increase can cause cerebral swelling. Read this Editorial Commentary on thirst, sodium & the hospitalized child.
link.springer.com/article/10.1...
CKDu in childrenβa commentary on evidence, insights, and prioritizing prevention
CKD is in WHOβs noncommunicable diseases prevention program to reduce premature mortality by 33% by 2030. There are stark regional differences in CKD burden that disproportionally affects low-income countries. Read this Editorial Commentary on CKDu in children.
link.springer.com/article/10.1...
Improvisation, innovation, inequity: peritoneal dialysis in low-resource settings
Read this Editorial Commentary on improvisation, innovation, & inequity: peritoneal dialysis in low-resource settings.
link.springer.com/article/10.1...
BK virus nephropathy in a native kidney
BK virus is a polyoma virus associated w/impaired graft function in kidney transplant recipients. After primary infection, the virus becomes latent in the renal/urinary epithelium. Read these Clinical Insights into BK virus nephropathy in a native kidney.
link.springer.com/article/10.1...
Measuring and estimating the GFR in children: state of the art in 2025
GFR can be measured directly, or estimated from biomarkers like serum creatinine & cystatin C, or both. Measuring GFR in children is cumbersome. Read this Review of measuring & estimating GFR in children: state of the art in 2025. Free access this month.
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Excessive screen time in relation to albuminuria in adolescents: a finding from the China Nutrition and Health Surveillance
Albuminuria is a sensitive marker of early kidney injury & serves as a key indicator for the diagnosis of CKD. Read this Original Article on excessive screen time re albuminuria in adolescents: a finding from the China Nutrition and Health Surveillance.
link.springer.com/article/10.1...
A brief review of some artificial intelligence methods in nephrology
Read this Review of 2 of the more commonly used AI methods encountered in nephrology publications: machine vision based on convolutional neural networks (CNNs) & chatbots, such as ChatGPT, based on large language models. Open Access
link.springer.com/article/10.1...
Early lactate elimination trend during therapeutic hypothermia predicts acute kidney injury in hypoxic ischemic encephalopathy
AKI is an important complication in neonates w/hypoxic ischemic encephalopathy (HIE). Read this Original Article on the association between early lactate elimination trend & AKI in neonates w/HIE receiving therapeutic hypothermia.
link.springer.com/article/10.1...
Neonatal acute kidney disease in the National Center for Child Health and Development (NCCHD)-neoAKI cohort: risk factors and prognostic outcomes
Acute kidney disease (AKD) is kidney dysfunction lasting 7β90 days after AKI onset. Read this Original Article on neonatal AKD in the National Center for Child Health & Development (NCCHD)-neoAKI cohort in Japan. Topical Collection: Advances in Neonatal Nephrology.
link.springer.com/article/10.1...
Unveiling long-standing low-molecular-weight proteinuria: A proximal tubular mitochondrial enzyme impairment caused by EHHADH mutation
Energy requirements of renal proximal tubular cells depend on mitochondrial fatty acid Ξ²-oxidation. Read these Clinical Insights on long-standing low-molecular-weight proteinuria: A proximal tubular mitochondrial enzyme impairment & EHHADH mutation.
link.springer.com/article/10.1...
Pediatric kidney health outcomes in communities impacted by chronic kidney disease of unknown etiology (CKDu): a systematic review
CKD of unknown etiology (CKDu) disproportionately affects young agricultural workers in Mesoamerica & South Asia who lack traditional risk factors for kidney disease. Read this Systematic Review/ Meta-analysis of outcomes in communities impacted by CKDu.
link.springer.com/article/10.1...
Kidney disease and transplantation in childhood cancer survivors
Advancements in pediatric cancer treatment have improved long-term survival. In childhood cancer survivors w/kidney failure, kidney transplant can be life-prolonging. Read this Educ Review of kidney disease & transplantation in childhood. Open Access.
link.springer.com/article/10.1...
Comparing German medical guidelines with recommendations by large language models using the example of hemolytic uremic syndrome (TMA)
With the advancement of large language models (LLMs), artificial intelligence has entered society & medicine. Read this Research Letter comparing German medical guidelines w/recommendations by LLMS using the example of hemolytic uremic syndrome.
link.springer.com/article/10.1...
ESPN Congress 2025 Athens, 13-18 October 2025
Read Abstracts from the European Society for Paediatric Nephrology (ESPN) Congress in Athens, Greece, Oct. 13-18, 2025.
link.springer.com/article/10.1...
Neutrophil extracellular traps drive peritoneal inflammation and tissue remodeling in pediatric peritoneal dialysis
Peritoneal dialysis (PD) sustains children w/CKD5 but promotes peritoneal membrane remodeling. Read this Original Article: Neutrophil extracellular traps drive peritoneal inflammation & tissue remodeling in pediatric PD. Open Access.
link.springer.com/article/10.1...
βWhy wonβt the ammonia go down?β: ammonia management while on continuous kidney replacement therapy
Kidney replacement therapy (KRT) is used to treat critically ill children for many reasons, including hyperammonemia. KRT mgmt in children w/hyperammonemia not due to inborn errors of metabolism is challenging. Read this Management Dilemma for more. Open Access.
link.springer.com/article/10.1...
Major contributors to musculoskeletal pain among children receiving hemodialysis
Children on hemodialysis are vulnerable to musculoskeletal (MSK) abnormalities, which can lead to functional impairments & diminished health-related quality of life. Read this Original Article on MSK pain among children on hemodialysis. Open Access.
link.springer.com/article/10.1...
Performance of creatinine and cystatin C-based equations to estimate glomerular filtration rate in African children with sickle cell anemia
Serum creatinine (SCr), a biomarker used to evaluate glomerular filtration rate (GFR), might be inaccurate in children w/sickle cell anemia (SCA). Read this Original Article on SCr- & cystatin C-based estimated GFR equations in African children w/SCA.
link.springer.com/article/10.1...
Randomized cross-over comparison of double mini-PET with standard versus adapted dwell volumes and dwell times in children on chronic peritoneal dialysis
Automated peritoneal dialysis consists of dwells w/the same dwell volume & time. Read this Original Article comparing double mini-peritoneal equilibration tests w/standard vs adapted dwell volumes & dwell times in children on chronic peritoneal dialysis.
link.springer.com/article/10.1...
Randomized controlled trial on efficacy and safety of torsemide versus furosemide in patients with nephrotic syndrome
Torsemide is preferred to furosemide in adults w/heart failure for its higher bioavailability & longer half-life. Read this Original Article on efficacy & safety of torsemide vs furosemide in pediatric patients w/nephrotic syndrome.
link.springer.com/article/10.1...
Establishing core outcomes and minimal clinically important differences for childhood steroid sensitive nephrotic syndrome clinical trials: results from a Delphi consensus process
Few randomized controlled trials are conducted in childhood nephrotic syndrome & global practice variation exists. Read this Original Article on childhood steroid sensitive nephrotic syndrome clinical trials: results from a Delphi consensus process.
link.springer.com/article/10.1...
The history and future landscape for paediatric ABO incompatible kidney transplantation
With limited donor availability & long wait times for deceased donor transplantation, ABO-incompatible kidney transplantation (ABOiKT) offers hope to children w/kidney failure. Read this Educ Review of the history & future landscape for pediatric ABOiKT.
link.springer.com/article/10.1...
Factors influencing serum uric acid levels and their impact on cardiovascular risk in patients with pediatric chronic kidney disease
Elevated serum uric acid levels are common in CKD & are associated w/cardiovascular disease. Read this Original Article on factors influencing serum uric acid levels & their impact on cardiovascular risk in patients w/pediatric CKD.
link.springer.com/article/10.1...
A rare case of hyperuricemia and acute kidney injury in a kidney transplant patient
Hyperuricemia is a common finding in kidney transplant recipients. Read these Clinical Insights into hyperuricemia & AKI associated w/use of cimetidine for treatment of mosaic warts in a pediatric kidney transplant patient. Open Access.
link.springer.com/article/10.1...
Multicenter evaluation of ambulatory blood pressure in children with CAKUT: distinctive profiles in the cystic dysplasia subgroup Original Article Published: 13 October 2025
Hypertension is an important risk factor in patients w/congenital anomalies of the kidney and urinary tract (CAKUT). Read this Original Article on ambulatory blood pressure in children w/CAKUT: distinctive profiles in the cystic dysplasia subgroup.
link.springer.com/article/10.1...
Recent progress in xenotransplantation and its application to pediatric kidney disease
Patients w/kidney failure require dialysis or kidney transplantation. Transplantation is often not possible due to a shortage of donor organs. Read this Review of xenotransplantation & its application to pediatric kidney disease. Free access this month.
bit.ly/4nxY1BG
The relationship between serum copeptin levels, peritoneal transport parameters, and bioimpedance markers in pediatric patients undergoing peritoneal dialysis
Pathophysiology of hypervolemia in CKD involves multiple mechanisms. Read this Original Article on the relationship between serum copeptin levels, peritoneal transport parameters & bioimpedance markers in pediatric patients undergoing peritoneal dialysis.
link.springer.com/article/10.1...
