David Rind

I'm inappropriately proud of this. I usually can't spot these at all, and am never first. Got lucky with an early notification and a very easy duplication!

Bottom row, the first through third blots on the left are copied as the second through fourth blots on the right.

The FDA and Gene Therapy for Duchenne Muscular Dystrophy This Viewpoint examines the appropriateness of FDA accelerated approval of novel gene therapies to treat boys with Duchenne muscular dystrophy following clinical trials with surrogate outcomes that di...

Posting this link now, for some reason....

jamanetwork.com/journals/jam...

Humility and grace are really important parts of being a caregiver in any situation, but particularly in an unfolding pandemic.

There is no chance you'll be right all the time. Admit that, accept it, and don't criticize others who are trying to do the same, even if you disagree with their choices.

concern that you would be wrong lead you to be unable to act. Many of the choices would be proven correct.

One of the parts of the COVID pandemic I've found most disheartening is the criticism some have gotten from other experts for being wrong some of the time.

I'd missed what I noted in the fall and winter of 2020 was an important similarity:

Things that you thought were true/correct/best care were proven wrong over and over.

And yet, you had to accept that you needed to provide what you believed to be the best care at the time and not let the

Great piece.

I got a similar question from an intern in mid March of 2020 as the situation began to unfold in Boston. He asked if I thought there was anything I'd learned during the AIDS pandemic that was applicable to COVID.

I told him that I thought the situations were very different.

But...

GRADE Certainty Ratings: Thresholds Rather Than Categories of Contextualization (GRADE Guidance 41) | Annals of Internal Medicine In 2017, the GRADE (Grading of Recommendations Assessment, Development and Evaluation) working group defined the certainty of evidence as the certainty that the true effect lies on one side of a thres...

www.acpjournals.org/doi/10.7326/...

Can This Trendy Anti-Aging Treatment Really Help You Live Longer?

If this turns out not to work, will you publish as long an article on how bizarre the idea is?
www.nytimes.com/2025/05/28/w...

I have zero reason to think that ice baths are good for you, but this study only shows that blood flow and incorporation of amino acids are reduced for a few hours after an ice bath. Pretty unsurprising.

It says nothing about eventual muscle strength or composition.

The accuracy is for matching with a PET scan finding of plaques, not for diagnosing AD, right?

Whereas I was suspecting that her mind was Tiffany twisted since she has such a lovely face.

Shooting from the hip, since I haven't read the study, but I'd be looking at socioeconomic factors. I'd wonder if children who got antibiotics early had a different diet and/or different amounts of calories from children who got antibiotics later. They saw a doctor who prescribed antibiotics...

Core GRADE 1: overview of the Core GRADE approach This first article in a seven part series presents an overview of the essential elements of the GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach that has proved extre...

#medsky
www.bmj.com/content/389/...

YouTube video by The Atlantic Peter Keisler and the Crises of Due Process | The David Frum Show

Exciting latest episode of The David Frum Show, on the many crises of due process under the Trump presidency. www.youtube.com/watch?v=xdBQ...

🧵hi, medical toxicologist and poisoning expert here

let's talk about pong-pong (“the suicide tree”) from The White Lotus #whitelotus #thewhitelotus 🪷

(yes it's real, yes it's deadly, and YES I HAVE OPINIONS)

Institute for Clinical and Economic Review Publishes Final Evidence Report on Treatment for Acute Pain: icer.org/news-insight...

Vaginal estrogen use in breast cancer survivors: a systematic review and meta-analysis of recurrence and mortality risks To assess the risk of breast cancer recurrence, breast cancer-specific mortality, and overall mortality for breast cancer survivors receiving vaginal estrogen therapy for genitourinary syndrome of men...

in women with breast cancer, but these data are unhelpful in answering the question. Relying on them is a bad idea.

If interested, the meta-analysis is:

www.ajog.org/article/S000...

/end

The problem is that this is not at all believable. Vaginal estrogen is not going to reduce mortality by these enormous amounts.

As such, the underlying studies are clearly so confounded as to make the evidence they provide pretty much worthless.

I'm not arguing that vaginal estrogen is unsafe
/3

to see if I could encourage this as a place for discussion.
Dr. Winter noted the below study on that other site. It shows something like a 40% reduction in cancer mortality and 55% reduction in all-cause mortality in women with treated breast cancer who then use vaginal estrogen.
/2

I bumped into a post from @ashleygwinter.bsky.social when I got an alert about a different post and wanted to make sure her (incredibly scary) medical stuff was improved.

She doesn't seem to be on BlueSky hardly ever, and I'm rarely at the other place. However, thought I'd post this here
/1

This is a great piece by Dr. Mell, and it's also really great that Retraction Watch decided to publish it. Thank you to all involved!

"I don't think anybody believes that these people would've been pardoned if they had engaged in exactly the same acts, but had stormed the Capitol, say, in opposition to the president and his policies," says Peter Keisler, former acting attorney general under Pres. Bush.

Hmm, sorry, I must have been confusing about this. We do include those costs when looking at a drug.

I think I was trying to answer whether ICER evaluates whether the cost of an ICU day or three hours in a surgery suite is priced according to value, and we don't typically evaluate that.

Again today... and was in the NY Times crossword in the past few days.

I have a big ask. My 9yo son is autistic and he’s been raising a betta fish he named Kevin. Yesterday He asked if he could “share a photo of Kevin with the whole world“. I don’t know if this will work, but a dad’s gotta try. Like and share if that’s your thing. Kevin says hi! 🐟👋

Billed as nonaddictive, new pain pill could soon win FDA approval A non-opioid painkiller from Vertex Pharmaceuticals could become a blockbuster, but questions remain on whether it will prove safe and effective for chronic pain.

www.washingtonpost.com/health/2025/...

Pretty sure that makes you one of like 12 people in the world who have figured out what's being said in that lyric.

"Pride and Prejudice" the novel is great.

The BBC version isn't perfectly faithful to the text, but it's an amazing adaptation.

There are goals beyond "understand[ing] the novels", such as enjoying a wonderful number of hours watching the BBC version.

Yes, read the book, but also watch the BBC.

Oh, sure, but "avaunt" is counted.

I try to use "avaunt" in at least one conversation every day.