Stephanie Xie

Check out our new preprint on an epigenetic resistance mechanism to PI3 kinase inhibition in AML and a new combination therapy with an EZH1/2 inhibitor that depletes leukemic stem cells! Great effort by @thehematopoet and the whole team

The Myeloid Workshop is back in ASH! Please contact the organizers if you have an exciting story that will not be out by December they are: Zuzana Tothova ,
@ernstlaboratory.bsky.social
@steidluli.bsky.social
@ericpietras.bsky.social
@kathrinbernt.bsky.social
@gritsmanlab.bsky.social

Febs workshop poster

Travel grants for trainees are available for the stellar FEBS Workshop on Aging in Hematopoiesis that will take place in Crete on October 20-24. Deadline for applications: July 31. More info: aginginhematopoiesis2025.febsevents.org/travel-grants

So proud of Team Stemmy! Interdisciplinary collabs are the way to make a difference for preventing and curing cancer. @pmresearch-uhn.bsky.social @uwaterloo.ca

Those in #Milan for #EHA2025, catch Angelica Varesi in her oral on this story live.

🎤 "Discovery of ATP2B1+ CD49f+ Human Hematopoietic Stem Cells with Superior Long-term Multilineage Reconstitution"
🗓 Thursday, June 12 | 🕔 17:00–17:15 CEST
📍 Brown Hall 1

ATP2B1 expression identifies human hematopoietic stem cells across… | Stephanie Xie Those in #Milan for #EHA2025, catch Angelica Varesi in her oral on this story live. 🎤 "Discovery of ATP2B1+ CD49f+ Human Hematopoietic Stem Cells with Superior Long-term Multilineage Reconstitu...

Preprint alert🚨‼️
I am beyond thrilled to share with the 🧪 community the characterization of ATP2B1, a new human immunophenotypic long-term 🩸hematopoietic stem cell marker across ontogeny in fetal liver, cord blood and adult sources. @pmresearch-uhn.bsky.social #teamscience

Thank you Vijay. So sorry to have missed you at AACR.

Stephanie Xie lab logo

This month has been a whirlwind. I am happy to announce I am the newest Scientist @pmresearch-uhn.bsky.social

The Xie lab 🧪will focus on understanding how inflammatory and metabolic stress promote aging and cancer risk in human🩸hematopoietic stem cells and preventative interventions.

This is the most deserving of honors. Congratulations to my long-time mentor Dr. John Dick!

Congratulations to our Senior Scientist Dr. John Dick on being elected into the National Academy of Sciences. @nationalacademies.org

Thank you @bradwouters.com. You are too kind.

Congratulations @stephxie.bsky.social already a star @uhntoronto.bsky.social @pmresearch-uhn.bsky.social

@aircanada.bsky.social Please get your act together. I will miss the plenary session of #AACR2025 and learn about groundbreaking cancer research because my flight got canceled 20 minutes before boarding. Unexpected mechanical failure. Last month too. That’s an awful trend.

This year’s 11 NextGen Stars will share their findings on cancer cartography, the dark proteome, cancer-resistant tissues, and more at #AACR25. Learn more about their work and its future implications on the #AACRBlog: www.aacr.org/blog/2025/04...

I had so much fun. 🙏@eirinipapapetrou.bsky.social, Elvin Wagenblast, Chris Sturgeon, Franco Izzo for the hospitality @sinaiirm.bsky.social
A 2 for 1 visit with insightful feedback from the Leukemia Working Group.

Manhattan skyline from the plane at descent.

Still a New Yorker at heart. I love the skyline of my childhood city. Looking forward to talking 🩸🧪science with colleagues at Icahn Mount Sinai and MSKCC and seeing family.

Canadian scientist Daniel Drucker among winners of Breakthrough Prize for discovery of hormone used in anti-obesity drugs Senior investigator at Mount Sinai Hospital was one of five researchers jointly awarded US$3-million in world’s largest science prize

Huge congratulations to @danieljdrucker.bsky.social and fellow scientists for the Breakthrough Prize in Life Sciences on the 🧪discoveries leading to development of GLP1R agonists. www.theglobeandmail.com/canada/artic...

Screenshot of the 2025 NextGen Stars Cancer Discovery commentary

I am thrilled to be included with this amazing group of scientists as part of the 2025 AACR NextGen Stars. Here are the challenges and future 🧪directions we have identified in our respective areas of cancer research. doi.org/10.1158/2159...

Registration for the 2025 FEBS Workshop on the Molecular and Cellular Pathways of Aging in Hematopoiesis in Crete on October 20-24 is live! Check out the amazing lineup of invited speakers on normal and malignant 🩸🧪, CH, inflammation, niche and much more. lnkd.in/eamN_YHs

a cartoon says hey everybody an old man 's talking while bart simpson looks on ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on

Bluetorial: Women, courage, and leadership

What follows will include some generalizations based on population averages of what I have experienced over the course of my career. There are, of course, exceptions in every group who are substantially more to one extreme or the other.

Women in cancer research and oncology March 8 is International Women’s Day. Women, particularly women of color, are still underrepresented in science and medical careers and face severe health disparities. To commemorate this day, we aske...

I want to live in a world where the words “women” and “female”are not censored, where women scientists are not sidelined, and all girls know they will always have a place here. Revisiting: Women in cancer research and oncology: Cancer Cell www.cell.com/cancer-cell/...

important study of 🩸#stemcells in aging mice. huge translational opportunities for decreasing cancer risk if we can uncover the mechanisms underlying HSC clonal dynamics differences from humans. Kudos to @goodell-lab.bsky.social
@seungchii.bsky.social

Our Bearded dragon named Jack enjoying the blue sky and sunshine.

My husband had to listen to me for an hour last night expounding on the dire straits of American science and the awful ramifications to health outcomes for US citizens and the world alike. But we must still take heart and look for the 🦋and 🌞 like our pet Jack.

Transcriptional activation of regenerative hematopoiesis via microenvironmental sensing - Nature Immunology Itkin et al. identify a role for Fli-1 in hematopoietic stem cell activation during regenerative hematopoiesis. They show that Fli-1 coordinates hematopoietic stem cells to stimulate niche-derived Not...

Check out this elegant 🧪publication showing that Fli-1 activity is essential for regenerative 🩸 hematopoiesis from Tomer Itkin and Shanin Rafii. I am delighted to have been included.
@weillcornell.bsky.social @pmresearch-uhn.bsky.social

www.nature.com/articles/s41...

Fig 2 of preprint showing CHIP mutations and transcriptional profiling of PBMCs.

Uncovering molecular mechanisms of longevity in an 116yo woman by multiomics profiling. She had 3 CHIP mutations (2 TET2 mutations and 1 SF3B1) but she had a remarkably high composition of memory T cells and B cells in her 🩸. How many distinct #HSC clones did she have? tinyurl.com/SuperagerM116

Very cool new study showing inflammation driven epigenetic memory encoded by AP-1 in colon stem cells increases cancer risk.

A shining example....there are 1,000s of these fundamental science discoveries that NIH supports to promote human health