Jen L, PhD

Analysis of 346 BCBM cases from the GEICAM RegistEM registry reveals faster CNS progression and poorer survival in TNBC and HER2+ subtypes, with major differences between de novo vs subsequent brain metastases.
🔗 buff.ly/74yHwuH
#BreastCancer #BrainMets #HER2 #TNBC #RealWorldEvidence

A rev in Ther Adv Med Onc highlights the unique challenges of early breast cancer in young BRCA carriers-covering surveillance, risk‑reducing surgery, PARP‑based therapy, fertility considerations, and survivorship needs. 🔗https://buff.ly/6fj4pvT
#BreastCancer #BRCA #Oncology #YoungPatients

Safety and Efficacy of CT-Guided Lung Biopsy in Elderly Patients age 75 Years and Older: A Single-Centre Retrospective Comparative Study
@tcrtcancer.bsky.social
@journals.sagepub.com

journals.sagepub.com/doi/10.1177/...

#lungcancer #diagnostics #oncology #cancerresearch #openaccess

Comprehensive versus thrombectomy-capable stroke centers: a web-based model to predict outcomes after mechanical thrombectomy - Shujuan Gan, Weifeng Huang, Tingyu Yi, Wenli Zhang, Xiongwei Lu, Zhiting... Background: The quality and clinical outcomes of mechanical thrombectomy (MT) performed at thrombectomy-capable stroke centers (TSCs) versus comprehensive strok...

New research online!
When patients undergo mechanical thrombectomy, does being treated in a thrombectomy-capable versus comprehensive #stroke center affect the outcomes?
Find out more here: journals.sagepub.com/doi/full/10....

Does noninvasive ventilation during pulmonary rehabilitation help improve patient outcomes? Read our latest article to find out!

journals.sagepub.com/doi/10.1177/...

📄New research online!

💊What is the real-world effectiveness of #cladribine tablets in people with #MultipleSclerosis?

👨‍⚕️Matteo Lucchini and colleagues analyzed data from multiple centers in Italy:
journals.sagepub.com/doi/full/10....

Top Read Papers on Natural Product Communications - February 2026

💡4. Chemical Constituents and Antimicrobial Activity of the Halophyte Atriplex leucoclada

journals.sagepub.com/doi/10.1177/...

New online!
Here, Bhupendra Khatri and colleagues discuss their experiences in therapeutic plasma exchange in autoimmune neurological disorders: journals.sagepub.com/doi/full/10....

New review - The treatment landscape for advanced gastric/GEJ adenocarcinoma is rapidly evolving. Upfront ICIs, targeted agents, and biomarker‑guided strategies are reshaping first‑line, maintenance, and sequential therapy.
🔗 buff.ly/22B0Oz0
#GastricCancer #GEJ #Immunotherapy #TargetedTherapy

A review in Ther Adv Med Onc summarizes major advances in SCLC: chemo‑IO as standard in ES‑SCLC, durvalumab approved for LS‑SCLC, emerging options for relapse (lurbinectedin, tarlatamab), and evolving biomarkers/transcriptional subtypes. 🔗https://buff.ly/LoHtjYT
#SCLC #LungCancer #Immunotherapy

Temporal dynamics of mesenchymal stem cell administration influence immune modulation in a 4T1 breast cancer model
doi.org/10.1177/0963...
#MSCs #CancerTreatment
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Cellular replacement therapy for diabetes
doi.org/10.1177/0963...
#diabetes
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Incidence and clinical relevance of donor-derived recipient-specific anti-HLA antibodies in haploidentical hematopoietic stem cell transplantation: a retrospective study
doi.org/10.1177/0963...

Allogeneic hematopoietic stem cell transplantation for the treatment of chronic active Epstein–Barr virus infection
doi.org/10.1177/0963...
#stemcell #transplantation #virus
@journals.sagepub.com

New research online! 📰
Is horizontal switching a valid #MultipleSclerosis treatment strategy?

Enrique Gomez-Figueroa and colleagues analyzed the MSBase Registry to find out the real-world effectiveness of horizontal switching between disease-modifying therapies:
journals.sagepub.com/doi/full/10....

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Strongyloides hyperinfection can occur without eosinophilia—even with CD4 >500 and undetectable HIV viral load. Early diagnosis is lifesaving ⚠️
journals.sagepub.com/doi/full/10....

Real‑world evidence in Ther Adv Med Onc shows nal‑IRI/5‑FU/LV significantly improves OS in pancreatic adenocarcinoma (28.0 vs 18.3 months) despite higher cost (ICER $33,285/LYG). 🔗https://buff.ly/dOq2XvY
#PancreaticCancer #GIOnc #RealWorldEvidence #HealthEconomics

Thank you for featuring this important research published in @tcrtcancer.bsky.social!

@apploniarose.bsky.social
@journals.sagepub.com

#oncology #cancerresearch #lymphoma #openaccess

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New online!
This large (>20000 patients) cohort study on secondary #stroke prevention describes the challenges in adherence to secondary stroke prevention medication in China:
journals.sagepub.com/doi/full/10....
#MedSky #NeuroSky

French consensus published in Ther Adv Med Onc-provide practical, real‑world guidance to prevent and manage hematologic toxicities from PARPis in metastatic PC-an area of growing need.
🔗 Full article: buff.ly/9fa08rG
#ProstateCancer #mCRPC #PARPInhibitors #Oncology

A new multicenter Chinese study in Ther Adv Med Onc evaluated PARPi in metastatic #breastcancer with HRR gene pathogenic variants.
mPFS reached 6.0 months, with consistent benefit across BRCA1/2, PALB2 and other HRR mutations.
🔗 buff.ly/x4JnB05
#MBC #PARP #HRR

Happy Lunar New Year’s Eve! 🎇
Welcoming the Year of the Horse with gratitude for a year working alongside the global oncology community through Therapeutic Advances in Medical Oncology and Sage Oncology journals.
Wishing everyone health, energy, and new breakthroughs in the year ahead. 🐎✨ 马年大吉！

Regional perfusion parameters as potential indicators of parenchymal hematoma risk following reperfusion therapy for acute ischemic stroke in the extended time window - Xinyu Liu, Lan Hong, Guangjian ... Background: Parenchymal hematoma (PH) is a common complication of acute ischemic stroke, particularly following reperfusion therapy. Objective: This study aime...

New article out in our Special Collection on Acute Reperfusion Therapies for Acute Ischemic Stroke:

Is there a relationship between regional perfusion parameters and parenchymal hematoma outcomes in #stroke patients treated in the extended time window?
journals.sagepub.com/doi/full/10....

📝 New #SystematicReview & Meta-Analysis online!

🧠 What is the safety and efficacy of initiating oral anticoagulants versus avoiding anticoagulation in adults with #AFib after spontaneous intracranial hemorrhage?

🗂️ This article draws evidence from #stroke RCTs:
journals.sagepub.com/doi/full/10....

Introduction - I lead a team of amazing PhD Managing Editors that support @journals.sagepub.com 's Open Access Clinical Journals. I share articles from our journals that I find interesting. Happy to connect with researchers! Also on LinkedIn and ResearchGate. 📖🔬🧪💊 #medicine #oncology #neuro #cardio

Sage Journals: Discover world-class research Subscription and open access journals from Sage, the world's leading independent academic publisher.

Invasive pulmonary aspergillosis remains a lethal threat in immunocompromised and post-COVID patients 🦠 Advances in PCR, lateral flow assays, and immuno-PET/MRI are reshaping diagnosis, but rising azole resistance demands susceptibility testing
journals.sagepub.com/doi/full/10....

ctDNA findings from the Ni‑High phase Ib trial: ERBB2 focal amplification and early mMAF decline strongly predict improved outcomes with trastuzumab + nivolumab + chemo in HER2+ aGC.
🔗https://buff.ly/S2kBuFe
#GastricCancer #HER2 #ctDNA

New review highlights how PSMA‑targeted radioligand therapy, including 177Lu‑PSMA‑617 and emerging isotopes like 225Ac/161Tb, is reshaping advanced prostate cancer care. Combination strategies and precision dosimetry point to a rapidly evolving future.
🔗 buff.ly/WKhPij0
#ProstateCancer #RLT #PSMA

From schizophrenia to dementia: Is Cobenfy a potential treatment for behavioral and psychological symptoms of dementia?

Journal of International Medical Research
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journals.sagepub.com/doi/10.1177/...

#neuropsychiatric #pharmacology #medicine #research #openaccess

Clinical efficacy and safety of endoscopic ultrasound-guided ablation therapies for pancreatic neuroendocrine tumors: a systematic review and meta-analysis
@tagastroenterol.bsky.social
@journals.sagepub.com

journals.sagepub.com/doi/10.1177/...

#pancreaticcancer #raretumors #oncology #openaccess