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Jen L, PhD

@drjkyl.bsky.social

Executive Editor/Team Leader Open Access Science Journals Sage Publishing Opinions = mine http://linkedin.com/in/jlovick-editor #oncology #cancerresearch #medicine #biology #cardiology #neurology #microbiology #publichealth #healthcare #technology

2,318 Followers  |  13,489 Following  |  240 Posts  |  Joined: 17.02.2025  |  1.5467

Latest posts by drjkyl.bsky.social on Bluesky

🚨 Call for Papers – Special Collection! @tamedoncol.bsky.social seeks submissions on: De-escalation of Treatment in Gynecologic Cancers. πŸ—“οΈ Submit by March 18, 2026 πŸ“₯ Submit:

10.10.2025 07:15 β€” πŸ‘ 2    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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Sage Journals: Discover world-class research Subscription and open access journals from Sage, the world's leading independent academic publisher.

Systematic review/meta-analysis (2013–2024, n=23,319): In febrile neutropenia after chemotherapy, bloodstream infections were 59% Gram-negative, 39.7% Gram-positive, and 2.5% fungal.
journals.sagepub.com/doi/full/10....

10.10.2025 12:41 β€” πŸ‘ 2    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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In patients with metastatic #gastriccancer, earlier nivolumab monotherapy infusions (before 14:00) were associated with significantly longer PFS and OS (7.6 vs 3.9 mo). Authors suggest infusion timing may influence outcomes in #Immunotherapy practice.

πŸ”— journals.sagepub.com/doi/epdf/10....

10.10.2025 15:48 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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In HER2-mutated non-small-cell lung cancer, combination regimens achieved markedly better outcomes than single-agent approaches.
Median PFS: 7.8 vs 5.3 mo; best results seen with chemo + immunotherapy + anti-angiogenic therapy.

πŸ”— journals.sagepub.com/doi/epdf/10....

10.10.2025 15:51 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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In HER2+ salivary duct carcinoma, trastuzumab-deruxtecan (T-Dxd) achieved 13 months of disease control in a multitreated 44-year-old patient, supporting further study of anti-HER2 therapy in rare salivary tumors.

πŸ”— journals.sagepub.com/doi/epdf/10....

#HER2 #SalivaryCancer #Oncology

10.10.2025 15:54 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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In HR+ advanced #BreastCancer progressing after CDK4/6 inhibitors, network meta-analysis (19 RCTs; n=6621) found CDK4/6i + fulvestrant most effective for PFS, especially in visceral metastases or ESR1 mutations; Bcl-2i + Ful and SERDs also showed benefit

journals.sagepub.com/doi/epdf/10....

10.10.2025 15:57 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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In non-metastatic HER2βˆ’ #BreastCancer, NCDB data (2018) showed higher pCR rates with neoadjuvant chemo in HR-Low vs HR-High groups. HR-Low tumors had higher grade/stage and lower endocrine therapy use, underscoring need for clearer treatment guidance.

πŸ”— journals.sagepub.com/doi/epdf/10....

10.10.2025 15:59 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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In #ParkinsonsDisease, orthostatic hypotension (OH) is a disabling feature linked to poor quality of life and fall risk. This review summarizes pharmacologic and nonpharmacologic strategies for managing OH in PD.

πŸ”— journals.sagepub.com/doi/epdf/10....

10.10.2025 16:08 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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In rescue stenting after failed thrombectomy, dual antiplatelet therapy post-procedure improved outcomes and reduced mortality and stent occlusion vs single therapy. Most occlusions occurred within 24 h, underscoring early management importance.

πŸ”— journals.sagepub.com/doi/epdf/10....

10.10.2025 16:09 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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In #ALS, analysis of 636 patients (2013–2023) found racial and ethnic disparities in care: Non-Hispanic Black patients had higher tracheostomy rates, and Hispanic patients were less likely to receive riluzole. Survival was similar across groups.

πŸ”— journals.sagepub.com/doi/epdf/10....

10.10.2025 16:11 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

🧬 Article collection on @tamedoncol.bsky.social: PARPi in Gynecologic Cancers. This collection highlights research on HRR genetic landscape, PARPi outcomes, oxaliplatin sequencing in BRCA-mutated ovarian cancer, and PARPi resistance with combination strategies. πŸ“š Explore more

07.10.2025 07:15 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Zolbetuximab is gaining attention as a targeted therapy for CLDN18.2-positive gastric and GEJ cancers.
This review dives into the science behind Claudin18.2 and the clinical promise of zolbetuximab, backed by SPOTLIGHT and GLOW trial data.
buff.ly/ok6eO7y
#Oncology #GastricCancer #Zolbetuximab

08.10.2025 07:15 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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BRCA1/2-mutant early #BreastCancer: review urges region-tailored testing in Latin America, MRI-first screening, and shared surgical decision making. Neo-adjuvant platinum can raise pCR, while adjuvant olaparib improves OS. #BRCA #TNBC #PARPi #Latam

06.10.2025 16:54 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Lung cancer is varying by region in risks and traits. A new article examines carcinogens, genetic predisposition, and molecular epidemiology. We seek submissions on geographic differences in lung cancer. Deadline: Dec 31, 2025 πŸ”— buff.ly/JCo9lJP #CancerResearch #LungCancer #GlobalHealth

05.10.2025 07:15 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Real-world analysis of HER2-ultralow in HR+/HER2– metastatic breast cancer: prevalence and first-line chemotherapy outcomes
@tamedoncol.bsky.social
@linglingtian.bsky.social
@journals.sagepub.com

journals.sagepub.com/doi/10.1177/...

#cancertreatment #precisiononcology #ADCtherapy #oncology

03.10.2025 21:52 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Design of an artificial natural killer cell mimicking system to target tumour cells
Journal of Tissue Engineering
@journals.sagepub.com

journals.sagepub.com/doi/10.1177/...

#immunotherapy #nanomedicine #NKcells #targeteddrugdelivery #openaccess

03.10.2025 21:49 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Is Site of Radiation Therapy Associated With Pathologic Complete Response in Patients With Locally Advanced Esophageal Cancer?
@cancer-control.bsky.social
@journals.sagepub.com

journals.sagepub.com/doi/10.1177/...

#radiationoncology #radiotherapy #cancercare #cancertreatment #openaccess

03.10.2025 21:47 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Identification of Potent HDAC6 Inhibitors for Breast Cancer Through Multi-Stage In Silico Modeling
Bioinformatics and Biology Insights
@journals.sagepub.com

journals.sagepub.com/doi/10.1177/...

#cancerresearch #precisiononcology #drugdiscovery #openaccess

03.10.2025 21:45 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Cardioprotective effectiveness of SGLT2 inhibitors in older diabetic women with early-stage breast cancer following anthracycline- and/or trastuzumab-based treatment
@tamedoncol.bsky.social
@linglingtian.bsky.social
@journals.sagepub.com

journals.sagepub.com/doi/10.1177/...

#cardiooncology

03.10.2025 21:44 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Understanding the Impact of Individual Nucleotide on Oxford Nanopore Current Signals With Interpretable Prediction Models
Bioinformatics and Biology Insights
@journals.sagepub.com

journals.sagepub.com/doi/10.1177/...

#nanoporesequencing #bioinformatics #DNAsequencing #MachineLearning #openaccess

03.10.2025 21:41 β€” πŸ‘ 3    πŸ” 1    πŸ’¬ 0    πŸ“Œ 1
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A patient-specific engineered tissue model of BAG3-mediated cardiomyopathy
Journal of Tissue Engineering
@journals.sagepub.com

journals.sagepub.com/doi/10.1177/...

#cardiactissueengineering #dilatedcardiomyopathy #iPSCmodels #precisioncardiology #openaccess

03.10.2025 21:39 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Early and hereditary breast cancer: advances in risk stratification and imaging approaches
@tamedoncol.bsky.social
@linglingtian.bsky.social
@journals.sagepub.com

journals.sagepub.com/doi/10.1177/...

#precisiononcology #radiomics #hereditarycancer #IAIinHealthcare #openaccess

03.10.2025 21:37 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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The CHD Protein, Kismet, Restricts Synaptic BMP Signaling at Glutamatergic Synapses
Neuroscience Insights
@journals.sagepub.com

journals.sagepub.com/doi/10.1177/...

#chromatinremodeling #synapticplasticity #neurodevelpmentaldisorders #openaccess

03.10.2025 21:33 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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New article shows Claudin 18.2 expression does not impact immunotherapy outcomes in Advanced Gastric Cancer treatment
@tamedoncol.bsky.social
@linglingtian.bsky.social
@journals.sagepub.com

journals.sagepub.com/doi/10.1177/...

#cancertreatment #oncology #immunotherapy #chemotherapy #openaccess

03.10.2025 21:31 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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A Preliminary Prospective Study on the Association of Polymorphisms in BDNF, ARRB2 and KCNJ6 and Response to Fentanyl for Pain Management in Advanced Cancer
@cancer-control.bsky.social
@journals.sagepub.com

journals.sagepub.com/doi/10.1177/...

#cancercare #dosingguidelines #pharmacogenomics

03.10.2025 21:27 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Effect of dapagliflozin on proteinuria and the slope of the estimated glomerular filtration rate in patients with immunoglobulin A nephropathy: A multicenter prospective study
Journal of International Medical Research
@journals.sagepub.com

journals.sagepub.com/doi/10.1177/...

#kidneyresearch

03.10.2025 21:24 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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🦠 Phytochemicals in the Transmission Control of Epidemic Viruses: A Review Focused on SARS-CoV-2, Zika, and Dengue 🀚🏽
An analysis of the antiviral potential of phytochemicals and their applications in the prevention and treatment of SARS-CoV-2, Zika, and dengue.
journals.sagepub.com/doi/10.1177/...

02.10.2025 12:20 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Sage Journals: Discover world-class research Subscription and open access journals from Sage, the world's leading independent academic publisher.

πŸ“Š HIV from injection drug use is climbing (2016–2022).
PrEP uptake in PWID remains critically low.
Call to action: integrate ID + addiction care, expand low-barrier services, implement LA-PrEP, and fight stigma through policy + education.
journals.sagepub.com/doi/full/10....

02.10.2025 14:34 β€” πŸ‘ 3    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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🚨Call for Papers: @tamedoncol.bsky.social invites submissions on Antibody Drug Conjugates (ADCs) in Gynecologic Cancers. Led by Dr. AngΓ©lica Nogueira Rodrigues & Dr. Rowan Miller, this collection spotlights innovative ADC research in gynecologic oncology. πŸ“₯ Submit your work. buff.ly/RhdEIHX

03.10.2025 07:15 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Systematic review & network meta-analysis in advanced EGFR-mutated #NSCLC after TKI failure: chemo+ivonescimab ranked best for PFS with acceptable safety; chemo+amivantamab gave strongest OS/ORR but higher toxicity. Chemo+IO or chemo alone less effective.

journals.sagepub.com/doi/epdf/10....

03.10.2025 14:47 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

@drjkyl is following 20 prominent accounts