Jen L, PhD

A large retrospective cohort shows CLDN18.2 expression does not influence outcomes of first‑line immunochemotherapy in HER2‑negative, pMMR, PD‑L1 CPS≥1 metastatic gastric/GEJ cancer.
🔗 buff.ly/rdAewUh
#GastricCancer #Immunotherapy #CLDN182 #Biomarkers

Prognostic impact of clinico-genetic characteristics and donor types in NPM1-mutated AML undergoing allogeneic hematopoietic stem cell transplantation - Xiaolin Yuan, Yibo Wu, Tingting Yang, Panpan Zh... NPM1-mutated acute myeloid leukemia (AML) is a distinct entity with specific biological and clinicopathological features. Prognosis varies depending on the asso...

Prognostic impact of clinico-genetic characteristics and donor types in NPM1-mutated AML undergoing allogeneic hematopoietic stem cell transplantation
doi.org/10.1177/0963...
#AML #blood
@sagepub_japan
@SageJournals

Ther Adv Med Oncol: Real‑world pyrotinib beyond progression vs rechallenge in HER2+ mBC (incl. brain mets): PFS2 ~7.2 vs 6.3 mo (NS); OS 31.6 vs 21.0 mo (trend). CNS subgroup also benefited. Read: 【🔗https://buff.ly/xsK4lFw 】 #BreastCancer #HER2 #BrainMets #Oncology

Advances in stem cell–derived beta-cell therapy: A new frontier in type 1 diabetes treatment
doi.org/10.1177/0963...
#celltherapy #diabetes
@journals.sagepub.com

Mechanisms and clinical prospects of mesenchymal stem cells and their derivatives in treating hypothyroidism-induced injuries: A focus on #cardiovascular, #skeletal muscle, and #nervous systems
doi.org/10.1177/0963...
#MSCs
@journals.sagepub.com

Collagen-hyaluronic acid hydrogel with embedded chondrocytes as a platform for modeling early stages of endochondral ossification in vitro
#bone #collagen
doi.org/10.1177/0963...
@journals.sagepub.com

#CancerScreening has impact only when systems can deliver diagnosis, referral, and treatment—not just detection. This Perspective discusses why cancer screening in resource-limited settings must be adapted to local capacity to achieve real #CancerControl impact. #GlobalHealth #LMICs #Oncology

🚨 Call for Papers – Special Collection: Precision Immuno‑Oncology
We welcome original research, clinical trials, reviews, and real‑world evidence shaping precision cancer care.
Guest Editor: Dr. Peng Luo
🔗 Submission details: buff.ly/fqWNKby
#ImmunoOncology #PrecisionMedicine #Biomarkers

A multicenter randomized trial shows PLD+carboplatin delivers non‑inferior PFS and significantly lower neurotoxicity and alopecia vs paclitaxel+carboplatin in 1L epithelial ovarian cancer. A promising taxane‑sparing option.
🔗 buff.ly/umFC4iX
#OvarianCancer #GynOnc #Chemotherapy #PLD #Paclitaxel

Sage Journals: Discover world-class research Subscription and open access journals from Sage, the world's leading independent academic publisher.

New article in TCRT: Genomic Justice as Reproductive Justice: Universal Coverage for Preimplantation Genetic Testing for Hereditary Breast and Ovarian Cancer Syndrome.

Read the article here: journals.sagepub.com/doi/full/10....

@umich.edu @journals.sagepub.com @oncodaily.bsky.social

📰New Review online on Hereditary Spastic Paraplegia:

🧬Understanding the specific genetic changes and advances in medical technology have enabled targeted and personalized treatments, including #GeneTherapy, repurposed drugs, and digital health tools:
journals.sagepub.com/doi/full/10....

Top Read Papers on Natural Product Communications - March 2026

💡1. Solvent Fractions of Parthenium hysterophorus leaves from the Borkena River, Ethiopia: Phytochemical Screening and Antibacterial Activity against Gram-Positive and Gram-Negative Human Pathogens

DOI:10.1177/1934578X261429601

Drug breakthrough for children with rare form of extreme epilepsy Families say the groundbreaking medicine is transforming the lives of children with Dravet syndrome.

Promising results of reduced #seizure frequency from early-phase trials of the antisense oligonucleotide #zorevunersen, administered via a spinal infusion in children with #Dravet syndrome:
www.bbc.co.uk/news/article...

New Plain Language Summary of a Publication online!
This #accessibleresearch summary explains the results from a Phase2b RCT and its open-label extension that looked at the safety and effects of #ecopipam in children and adolescents with #Tourette syndrome:
journals.sagepub.com/doi/epdf/10....
#PLSP

Read this novel study investigating an AI based tele rehabilitation app that enhanced access to pulmonary rehab in patients recovering from lung cancer surgery.

journals.sagepub.com/doi/10.1177/...

@ild-ipfdoc.bsky.social

📝 New Review online in our Special Collection on CAR T-cells in Autoimmune Neurological Disorders:

What is the role of neuroimaging in diagnosis and management of neurotoxicity in patients treated by CAR T-cell therapy?

Arian Lasocki and colleagues discuss:
journals.sagepub.com/doi/full/10....

Analysis of 346 BCBM cases from the GEICAM RegistEM registry reveals faster CNS progression and poorer survival in TNBC and HER2+ subtypes, with major differences between de novo vs subsequent brain metastases.
🔗 buff.ly/74yHwuH
#BreastCancer #BrainMets #HER2 #TNBC #RealWorldEvidence

A rev in Ther Adv Med Onc highlights the unique challenges of early breast cancer in young BRCA carriers-covering surveillance, risk‑reducing surgery, PARP‑based therapy, fertility considerations, and survivorship needs. 🔗https://buff.ly/6fj4pvT
#BreastCancer #BRCA #Oncology #YoungPatients

Safety and Efficacy of CT-Guided Lung Biopsy in Elderly Patients age 75 Years and Older: A Single-Centre Retrospective Comparative Study
@tcrtcancer.bsky.social
@journals.sagepub.com

journals.sagepub.com/doi/10.1177/...

#lungcancer #diagnostics #oncology #cancerresearch #openaccess

Comprehensive versus thrombectomy-capable stroke centers: a web-based model to predict outcomes after mechanical thrombectomy - Shujuan Gan, Weifeng Huang, Tingyu Yi, Wenli Zhang, Xiongwei Lu, Zhiting... Background: The quality and clinical outcomes of mechanical thrombectomy (MT) performed at thrombectomy-capable stroke centers (TSCs) versus comprehensive strok...

New research online!
When patients undergo mechanical thrombectomy, does being treated in a thrombectomy-capable versus comprehensive #stroke center affect the outcomes?
Find out more here: journals.sagepub.com/doi/full/10....

Does noninvasive ventilation during pulmonary rehabilitation help improve patient outcomes? Read our latest article to find out!

journals.sagepub.com/doi/10.1177/...

📄New research online!

💊What is the real-world effectiveness of #cladribine tablets in people with #MultipleSclerosis?

👨‍⚕️Matteo Lucchini and colleagues analyzed data from multiple centers in Italy:
journals.sagepub.com/doi/full/10....

Top Read Papers on Natural Product Communications - February 2026

💡4. Chemical Constituents and Antimicrobial Activity of the Halophyte Atriplex leucoclada

journals.sagepub.com/doi/10.1177/...

New online!
Here, Bhupendra Khatri and colleagues discuss their experiences in therapeutic plasma exchange in autoimmune neurological disorders: journals.sagepub.com/doi/full/10....

New review - The treatment landscape for advanced gastric/GEJ adenocarcinoma is rapidly evolving. Upfront ICIs, targeted agents, and biomarker‑guided strategies are reshaping first‑line, maintenance, and sequential therapy.
🔗 buff.ly/22B0Oz0
#GastricCancer #GEJ #Immunotherapy #TargetedTherapy

A review in Ther Adv Med Onc summarizes major advances in SCLC: chemo‑IO as standard in ES‑SCLC, durvalumab approved for LS‑SCLC, emerging options for relapse (lurbinectedin, tarlatamab), and evolving biomarkers/transcriptional subtypes. 🔗https://buff.ly/LoHtjYT
#SCLC #LungCancer #Immunotherapy

Temporal dynamics of mesenchymal stem cell administration influence immune modulation in a 4T1 breast cancer model
doi.org/10.1177/0963...
#MSCs #CancerTreatment
@journals.sagepub.com

Cellular replacement therapy for diabetes
doi.org/10.1177/0963...
#diabetes
@journals.sagepub.com

Incidence and clinical relevance of donor-derived recipient-specific anti-HLA antibodies in haploidentical hematopoietic stem cell transplantation: a retrospective study
doi.org/10.1177/0963...

Allogeneic hematopoietic stem cell transplantation for the treatment of chronic active Epstein–Barr virus infection
doi.org/10.1177/0963...
#stemcell #transplantation #virus
@journals.sagepub.com