Stefano Crespi

Autonomous Activation of a Gated Chemiluminescent Photosensitizer Enables Targeted Photodynamic Therapy in Tumor Cells Chemiluminescence-based photodynamic therapy (CLPDT) offers a promising solution to the light penetration limits of traditional PDT. However, it lacks spatiotemporal control. Intracellularly activated...

We developed an AND-gated chemiluminescent photosensitizer that only generates light inside tumor cells, activating under 2 cancer cell-specific conditions.
Many thanks to Wenwu Peng @pengww.bsky.social from Seah Ling Kuan's group @seahling.bsky.social & our collaborators! shorturl.at/uXTg3

Semi‐Automated Pipeline for Transition State Search of Molecular Photoswitches A semi-automated pipeline for the transition state search of molecular switches (PiTS3) is reported, which facilitates the search, optimization, and conformational analysis of transition states of ph...

Our pipeline to compute thermal barriers of photoswitches💡 is out!🥳 We especially focused on NBDs for MOST🔋 and imines, but also stilbenes and DAEs. Try it out! You need just chemdraws and freeware to get libraries computed

doi.org/10.1002/cptc...

Almost there! :D

Over the moon that the first paper from Anja's studies on metal chelate rotaxanes is now online in @angewandtechemie.bsky.social. doi.org/10.1002/anie...
Massive congratulations Anja,
@daisypooler.bsky.social Huseyn, Monika and @screspi.bsky.social 🥳🎉🎊🍀🥃

Thread below --》

The Effect of Aldehyde and Carboxylic Acid Substitution on the Isomerization of Hemithioindigo Photoswitches Hemithioindigo (HTI) photoswitches exhibit robust photoisomerization under visible light and relatively high thermal bistability. In this work, we report various modifications of the HTI core, namely....

Mati's work on aldehyde and COOH effect on HTIs is out! Nice collaboration with the Ott group for the inclusion and switching of HTIs in MOFs💡 doi.org/10.1002/chem...

Cross-Coupling Reactions with Nickel, Visible Light, and tert-Butylamine as a Bifunctional Additive Transition metal catalysis is crucial for the synthesis of complex molecules, with ligands and bases playing a pivotal role in optimizing cross-coupling reactions. Despite advancements in ligand desig...

Tert-butylamine as a labile ligand and base enables cross-coupling reactions with various nucleophile classes. A great collaboration of Jonas with the Sigman lab and Gschwind group
#ChemSky #ChemCollabs #photocatalysis

doi.org/10.1021/acsc...

Reposting this #molswitch #molmachine starter pack. If you want to be included in it, please let me know
go.bsky.app/EwimNbK

Here is a tentative Supramolecular Chemistry starter kit. Please let me know if you wish to be added ! #ChemSky
go.bsky.app/RjRgi6n

Great to be highlighted by @chemistryviews.bsky.social! Go pnictogen switches 😀 💡

Molecular Switch with a Variety of External Triggers:
Reversible molecular switching of a phosphaethene polyaromatic hydrocarbon by irradiation, metal coordination, or deprotonation
www.chemistryviews.org/molecular-sw...

Another C=P switch💡🅿️, this time with a metal twist 😀 great collaboration with @orthaberlab.bsky.social

Best way to explain transient spectroscopy

Now that @feringalab.bsky.social is here too, the race is open 😀

Our OrgChem Starter Pack is growing with already 122 entries, but we will start a volume 2 if we go over the 150 limit!
go.bsky.app/NSEFPFJ

Probing the Hidden Photoisomerization of a Symmetric Phosphaalkene Switch In this study, we present the synthesis and analysis of a novel, air-stable, and solvent-resistant phosphaalkene switch. Using this symmetric switch, we have demonstrated degenerate photoisomerizatio...

Absolutely delighted to see the light of this collaborative work between the @screspi.bsky.social team and our group, with all the spectroscopy help.
Demonstrating degenerate isomerisation of phosphaalkenes using NMR spectroscopy #chemsky #NMRchat
onlinelibrary.wiley.com/doi/10.1002/...

Thank you Oliver 😊

Probing the Hidden Photoisomerization of a Symmetric Phosphaalkene Switch In this study, we present the synthesis and analysis of a novel, air-stable, and solvent-resistant phosphaalkene switch. Using this symmetric switch, we have demonstrated degenerate photoisomerizatio...

Hey #Chemsky! For my first post, I am hyped to share our latest efforts on main group C=P photoswitches💡, where we explored their isomerization mechanisms and observed experimentally symmetric molecules switch via NMR!🧲🔍a great international collaboration! onlinelibrary.wiley.com/doi/10.1002/...

You ever have one of those amazing weeks when everything clicks in your multiple roles as an academic PI- scientist, mentor, parent, partner, colleague, psychologist, fundraiser, salesperson?

(Yeah, me neither.)

But screwing up each of these roles takes special talent.

(I am that talented.)

Postdoc position in reactive machine learning potentials

What better first post than to advertise this position. Come join our group!

Our group is recruiting a postdoctoral researcher for a project on reactive machine learning potentials. Reposts and spreading the word to interested people in your network appreciated!

jobs.ethz.ch/job/view/JOP...

Oh dear lord...

Here is a starter pack for folks into tiny switches and machines. I am sure I missed many. Please let me know if you should be included and I will add you
go.bsky.app/EwimNbK

I feel you...and the more things you have to do on top of it, the more it seems like a stressful chore where you stare at a blank page
But let's be positive! congrats on the editorial 😉

The Elbphilharmonie building in Hamburg surrounded by the Elbe river with blue skies and a few clouds.

Canal with houses and people on stand up paddling boards queuing at a waterside café

Summer day at the Alster lake in Hamburg with people on stand up paddling boards and a sailing boat

Would you like to spend the next summer in beautiful Hamburg doing some uranium chemistry? If you're an undergraduate student from the UK, Ireland or North America, you have 11 days left to apply for two fully funded research internships via the DAAD: www.daad.de/rise/en/rise... #chemsky