Amber Barton

Genomics uncovers new ways to target chronic childhood disease By sequencing the bacteria that cause the neglected disease yaws, researchers have found that while mass treatment can be successful, it can cause resistant strains to develop. They suggest that publi...

By sequencing the bacteria responsible for yaws, a debilitating childhood disease, experts have uncovered new insights into how these bacteria re-emerge and evade treatment 🧬

Find out how these can be used to help inform public health interventions ⤵️

www.sanger.ac.uk/news_item/ge...

Genomics uncovers new ways to target chronic childhood disease By sequencing the bacteria that cause the neglected disease yaws, researchers have found that while mass treatment can be successful, it can cause resistant strains to develop. They suggest that publi...

Really pleased to see our work on yaws, and how mass drug administration shapes Treponema genomes, published in @lancetmicrobe.bsky.social!

sanger.ac.uk/news_item/genomics-uncovers-new-ways-to-target-chronic-childhood-disease/

www.thelancet.com/journals/lan...

The image shows two box and whisker plots. The left hand plot shows the duration of peoples ulcers stratified by sub-lineage and demonstrates that one of these sub-lineages has a longer duration of ulcers than the others. The right hand plot shows the titre of treponemal antibodies stratified by sub-lineage and demonstrates that the same sub-lineage is also associated with much lower antibody titres than the others.

Out @lancetmicrobe.bsky.social & led @amberbarton.bsky.social We used WGS to look at Treponema population dynamics during community MDA for yaws tinyurl.com/bd6zu6xm

Intriguingly found sublineage associated w longer ulcer duration & lower antibody titres. Whether occurs in syphilis needs exploring

Evolution of Pandemic Cholera at its Global Source The seventh pandemic of cholera, caused by the 7th Pandemic El Tor Lineage (7PET) Vibrio cholerae, was previously shown to have emanated in three global waves from the Bay of Bengal, bordering Banglad...

Delighted to share our preprint on the evolution of pandemic cholera at its global source in the ganges basin!
doi.org/10.1101/2025.02.03.25321585

Congratulations!

Had a wonderful time at 17th Asian Conference on Diarrhoeal Disease and Nutrition in Nepal- fantastic to meet up with infection researchers from all over the world, share results, chair a session for the first time and explore Kathmandu!

The Effect of Repeated Mass Drug Administration on the Transmission of Yaws: A Genomic Epidemiology Study Background: Yaws, a neglected tropical disease caused by Treponema pallidum subspecies pertenue, has evaded eradication, in part due to a high proportion of asymptomatic cases. A cluster-randomised tr...

Pleased to share this preprint on Yaws transmission dynamics following mass azithromycin administration, led by Amber Barton www.medrxiv.org/content/10.1...
Following MDA campaign, we sequenced >half of infections, showing recrudescence driven by existing lineages & persistence linked to key SNPs.