Lauren de Haan

CIP2A is required for mitotic recruitment of the SLX1/XPF/MUS81 tri-nuclease complex to replication stress-induced DNA lesions to maintain genome integrity Perturbed DNA replication can lead to incompletely replicated DNA when cells enter mitosis and can interfere with chromosome segregation. Cells therefore require mechanisms to resolve these lesions du...

Extremely happy to share that my main PhD project about CIP2A-TOPBP1 and the SMX complex is now available online as pre-print.

Huge thanks to all co-authors but especially @marcelvanvugt.bsky.social for giving me the opportunity to work on this exciting project!

www.biorxiv.org/content/10.1...

04.04.2025 11:33 — 👍 19    🔁 6    💬 0    📌 0

WEE1 inhibitors trigger GCN2-mediated activation of the integrated stress response The WEE1 kinase negatively regulates CDK1/2 to control DNA replication and mitotic entry. Genetic factors that determine sensitivity to WEE1 inhibitors (WEE1i) are largely unknown. A genome-wide inser...

Happy to post a new study on BioRxiv, where we show Integrated Stress Response activation as an off-target effect of multiple clinically evaluated WEE1 inhibitors. Team effort with the lab of Dan Durocher @durocher1.bsky.social and many others. www.biorxiv.org/content/10.1...

18.03.2025 10:13 — 👍 31    🔁 12    💬 3    📌 0

Thank you to Roger Greenberg and Hilda Pickett for organising a fantastic 2025 Mammalian DNA Repair GRC in Ventura, California.

Looking forward to the next time.

07.02.2025 00:37 — 👍 15    🔁 5    💬 0    📌 0

RAD51 recruitment but not replication fork stability associates with PARP inhibitor response in ovarian cancer patient-derived xenograft models Abstract. Poly(ADP‐ribose) polymerase (PARP) inhibitors (PARPis) are currently used to treat BRCA1/2 mutant cancers. Although PARPi sensitivity has been at

Happy to share our study by Francien Talens and many colleagues on RAD51 foci formation as a functional marker for PARPi sensitivity in ovarian cancer PDX models. academic.oup.com/narcancer/ar...

30.11.2024 08:56 — 👍 28    🔁 10    💬 2    📌 0