A/Prof Sam Stehbens PhD (She/Her)

Actin fell in love with nucleus ❤️

#actin #cytoskeleton #nucleus #microscopy #cellbiology #research

Nuclear protein FNBP4: A novel inhibitor of non-diaphanous formin FMN1-mediated actin cytoskeleton dynamics Formin1 (FMN1), a member of the non-diaphanous formin family, is essential for development and neuronal function. Unlike diaphanous-related formins, FMN1 is not subject to canonical autoinhibition thr...

🚨 New publication out in @jbiolchem!
We show how FNBP4 inhibits FMN1-mediated actin dynamics, revealing key regulatory mechanisms of non-diaphanous formin. Grateful to @Maiti_SP for his guidance and @ANRFIndia for funding!
🔗 doi.org/10.1016/j.jbc.…
#ActinCytoskeletonwww.jbc.org/article/S002...xt

Our August issue is here! rupress.org/jcb/issue/22...
The cover shows confocal #microscopy image of a #Xenopus laevis zygote in metaphase of the first embryonic #mitosis stained to visualize the spindle. #Microtubules (magenta) and DNA (cyan). (Cantwell et al. rupress.org/jcb/article/...)

Look at the wee little #focaladhesions hanging on! Looks like a cell cyr wheel #mechanobiology #cytoskeleton

a woman is standing in front of a white board in a living room . ALT: a woman is standing in front of a white board in a living room .

I’d take this as buisness days

Data scientists, experimental biologists, mathematical modelers, and biophysicists interested in using machine learning to study cytoskeletal dynamics, cell migration, and mitosis are invited to join us for an upcoming workshop!

Apply today at www.nitmb.org/cytoskeletal...

Tubulin autoregulation tunes microtubule dynamics to support multicellular architecture and viability https://www.biorxiv.org/content/10.1101/2025.07.28.667019v1

SAME - except now my team are getting so good at figures they’re leaving me with less to do 😂

100% we need an independent ORI!

The cancer drug, the faked data and the superstar scientist An investigation can reveal the secret history of one of Australia’s top scientists, whose faked data underpins a drug now being given to patients.

Australia's failure to enforce research integrity: "CSIRO chief executive Doug Hilton said the Smyth case clearly highlighted the need for an independent research misconduct watchdog instead of allowing universities to investigate allegations against their staff." www.smh.com.au/national/the...

Sia was surprisingly absent too….

Already is

Ladies coming in strong at #4 & #3

Dance monkey is coming I can feel it

Explains a lot

two men are standing next to a bag that says uber eats ALT: two men are standing next to a bag that says uber eats

DOUBLE CHISEL #hottest100 🎉

Not just me it seems

Giving me faith in the kids

VINDICATION #tripleJ #hottest100 horses didn’t crack top 20. Phew, faith restored.

Right??? It’s not Kitsch ‘your the voice’ cool. It’s super daggy… he’s standing on the beach in white linen 🤮

a close up of a kangaroo looking at the camera ALT: a close up of a kangaroo looking at the camera

To the #Australians abroad who are homesick, #TripleJ is doing an oz #Hottest100
…although if Darryl Braithwaite Horses breaks top 10, I may reconsider my citizenship 😂

a cartoon of a man standing in front of a monster with a letter r on it ALT: a cartoon of a man standing in front of a monster with a letter r on it

This is giving me ‘By the power of Greyskull…’ vibes

I might be biased …,bc #microtubules ….but wow 🤩

Mayo looks a lot like my Phoebe! (Australian mist)

Protein design of two-component tubular assemblies similar to cytoskeletons The concept of this approach draws inspiration from natural biological systems, employing rational design principles to integrate naturally occurring ‘heterolinkers’ with ‘scaffold proteins’ to streamline the design process. For the heterolinker, we chose the heterodimeric peptide pair ‘MBD3L2 (M3L2)/p66α’ (Fig...

Protein design of two-component tubular assemblies similar to cytoskeletons
->Nature | More info from EcoSearch

Schematic showing the effect of acetylation on microtubule nucleation, microtubule elongation and shrinkage.

In this Opinion article, Yu-Ming Lu discusses multiple important studies on microtubule acetylation with the aim of clarifying the actual role of α-tubulin K40 acetylation, a major tubulin post-translational modification.
journals.biologists.com/jcs/article/...

WAVE complex forms linear arrays at negative membrane curvature to instruct #lamellipodia formation, say Muziyue Wu, Orion Weiner @oweinerlab.bsky.social and colleagues: rupress.org/jcb/article/...

#Biophysics #Cytoskeleton #Migration #Motility #Actin

Fantastic talk from @kelvintuong.bsky.social at IMB #UQ this morning. Importantly …another scientist who uses #cats in their talk. #CatsOfAcademia #IMB-alumni

Aceitón, Riobó, Del Valle Batalla, Yuseff et al show that B cells respond to mechanical cues at the immune synapse through ATAT1-dependent microtubule acetylation to coordinate cytoskeletal dynamics & lysosome positioning, enhancing antigen extraction and presentation rupress.org/jcb/article/...