We are looking for two exceptional Research Assistants!
1) Experimental, to drive forward quantitative studies of transcription factor function in development
2) computational, to develop and apply cutting-edge deep learning models of gene regulation.
Links below
π£ Preprint alert!
I am happy to share that our neural crest manuscript is now available on BioRxiv! www.biorxiv.org/content/10.6...
SS18::SSX activates Polycomb target genes without BAF β
Instead, transcription relies on EP300 via the SS18 QPGY domain
www.biorxiv.org/content/10.6...
β‘οΈ Coactivator targeting emerges as a new therapeutic strategy in synovial sarcoma π―
Team work from @banitolab.bsky.social and @uoe-igc.bsky.social
Array-CNCC: precise aggregation and arrayed plating facilitate quantitative phenotyping of human cranial neural crest cells and craniofacial disease modelling https://www.biorxiv.org/content/10.64898/2026.01.18.696654v1
19.01.2026 08:30 β π 1 π 2 π¬ 0 π 0
This was a fantastic collaborative effort - many congratulations to first authors Ewa and Kasia!
@ewaoz.bsky.social
@km-milto.bsky.social
And a big thank you to everyone who provided support, input and inspiration along the way.
π£ I'm excited to share our latest preprint!
We adapt and characterise a neurosphere-based CNCC differentiation protocol, and demonstrate utility for quantitative phenotyping and craniofacial disease modelling! π§«
Read about Array-CNCC here:
www.biorxiv.org/content/10.6...
@uoe-igc.bsky.social
π Many congratulations to Kasia Milto who successfully defended her thesis last week! It was so wonderful to have Kasia as the first PhD student in the lab, and to co-supervise with Jenny Nichols. So proud!
@km-milto.bsky.social
@uoe-igc.bsky.social
Super line-up of chromatin, epigenetics and gene regulation speakers coming your way from @aicc-ireland.bsky.social over the next 5 months!
15.01.2026 15:19 β π 4 π 1 π¬ 0 π 0
Latest from our lab: dx.plos.org/10.1371/jour... Congratulations to Veronika for leading this work to model cis-regulatory dynamics in F1s using single-cell allelic data
20.12.2025 06:36 β π 13 π 3 π¬ 1 π 0
Applications for our international #PhD program open until 11th Jan. Come work with us @uoe-igc.bsky.social and @hannahlong.bsky.social to understand DNMT3B in ICF syndrome or with our wonderful colleagues.
Details here:
institute-genetics-cancer.ed.ac.uk/igc-graduate...
#epigenetics Please repost π
Excited to share our work at @natcomms.nature.com
We used single cell proteomics to define the functional heterogeneity of human neutrophils in glioblastoma, finding pro and anti-tumorigenic effector states invisible to scRNAseq.
SCP will revolutionise immunology, this is just the start
An early Christmas present for those interested in chromatin and transcription! Fantastic work from @au-ho-yu.bsky.social and @aleksszczurek.bsky.social . Thanks to Inge and Michiel for their help. Please repost!
www.biorxiv.org/content/10.6...
JASPAR 2026 is out π
The new release massively expands the TF motif collections and adds a dedicated DeepLearning collection of motifs learned from deep learning models.
Database: jaspar.elixir.no
Paper (NAR): doi.org/10.1093/nar/...
π§΅1/2
We are thrilled to announce the first official release (v0.1.8) of #π―π²π±π±π²πΏ, the successor to one of our flagship tool, #π―π²π±ππΌπΌπΉπ! Based on ideas we conceived of long ago (!), this was achieved thanks to the dedication of Brent Pedersen.
1/n
Donβt miss out on this opportunity- come and join us at the Oxford Organoid Hub working under the MRC-BHF REACT programme! If you love in vitro 3D models, the β€οΈ and regenerative therapies, this is for you - apply by 18 Dec @oxforddpag.bsky.social @idrm.ox.ac.uk @rdm.ox.ac.uk
30.11.2025 23:02 β π 10 π 8 π¬ 0 π 0
Exciting opportunity to work on a collaborative PhD project with Duncan and myself modeling ICF1 syndrome in human stem cell models π§«
@sproullab.bsky.social
@uoe-igc.bsky.social
Applications are open for the MRC PhD programme in Human Genetics, Genomics and Disease at the University of Edinburgh!
Project 2: Use human ES cells to determine exactly how DNMT3B mutations cause ICF1 syndrome. Collaboration with @hannahlong.bsky.social:
institute-genetics-cancer.ed.ac.uk/igc-graduate...
Deadline 11th January 2026
This scheme is flexible if you are interested in other projects.
𧡠3/4
π¨ Multiple #PhD opportunities for lab or computational applicants. Do you want to understand the molecular basis of #epigenetic dysfunction in human disease?
Come work with our group at the fantastic, collaborative @uoe-igc.bsky.social in a beautiful, liveable city.
𧡠1/4
Please repost π
Very pleased to share our latest paper published in Cell:
BRAIN-MAGNET: A functional genomics atlas for interpretation of non-coding variants: Cell www.cell.com/cell/fulltex...
@cellpress.bsky.social, @cp-cell.bsky.social, @ruizhideng.bsky.social #enhancer
here is a thread about our findings:
Researchers have identified gene-regulatory variants that might have contributed to Neanderthalsβ beefy jaws β offering a window on how the human face developed
go.nature.com/3Ke6StJ
Congratulations!
19.11.2025 11:56 β π 2 π 0 π¬ 1 π 0
π¨Reposts appreciatedβΌοΈIf I had read this PhD offer five years ago, I wouldnβt have hesitated for a second to apply π
Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social π§¬β¨
#PhD #3DGenome
Join us for our free inaugural lecture & drinks reception. @jorisveltman.bsky.social will talk about the genetic causes of rare disorders such as reproductive disorders & Charlie Lees will tell the 20βyear story of change in IBD.
More info & registerπ bit.ly/3J766hJ
@cmvm-edinburghuni.bsky.social
Neanderthal DNA enhances our understanding of face development
This Research Highlight showcases the work from Hannah Long @hannahlong.bsky.social, Kirsty Uttley @kirstyuttley.bsky.social, Hannah JΓΌllig @hannahjuellig.bsky.social and colleagues: journals.biologists.com/dev/article/...
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
Enjoy the start of this new adventure! And hopefully Iβll see you soon in Europe βΊοΈ
10.11.2025 16:20 β π 0 π 0 π¬ 0 π 0Many congratulations Wendy, and to the whole team! Excited to see what you discover π§¬
10.11.2025 16:05 β π 0 π 0 π¬ 0 π 0Thanks Rob - so pleased to see the first paper from the lab published today βΊοΈ
10.11.2025 15:54 β π 1 π 0 π¬ 0 π 0
Left to right: Kirsty Uttley, Hannah Long and Hannah JΓΌllig at the Institute of Genetics and Cancer, overlooking the city of Edinburgh. Photo credit: Connor Warnock.
To learn more about how this story developed and the researchers behind it, we talked to co-first authors Kirsty Uttley and Hannah JΓΌllig, as well as corresponding author, Hannah Long
doi.org/10.1242/dev....
Excited to share our new paper out today in Development! Check out Hannahβs fantastic post below for a summary of the findings β¨
journals.biologists.com/dev/article/...
