Hannah Long

Group Leader - Genome Biology Unit Are you ready to lead groundbreaking research in Genome Biology? Join us at EMBL! We are seeking a motivated scientist to lead an independent research group addressing exciting and original biological...

To all post-docs: The Genome Biology dept ‪@embl.org
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

👇 Highly recommend applying if you want to join a great team and work on a high-profile, inter-university project! #postdocjobs

Image of an old building in Oxford with the heading 'postdoc opportunities' and the text 'computational approaches to improve rare disease diagnosis and treatment' and 'Big Data Institute, University of Oxford'

📣 We are recruiting! Please share!!

Are you a bioinformatician / computational scientist who wants to apply your skills to understanding regulatory biology and improving rare disease diagnosis and treatment? 🧠 💻 🧬 🩺

We have two roles available 👇

🧵 1/4

Single cell proteomic analysis defines discrete neutrophil functional states in human glioblastoma Neutrophils are vital innate immune cells shown to infiltrate glioblastomas, however we currently lack the molecular understanding of their functional states within the tumour niche. Neutrophils are k...

Happy to share our latest preprint doing low cell number (mini-bulk) and single cell #proteomics on tumour associated neutrophils from human glioblastoma where we find multiple functional states that would be invisible to scRNAseq, some showing pro-tumoural states with potential therapeutic value

MRC Postdoctoral Research Scientists x 5 - MRC Laboratory of Medical Sciences Applications are now open for up to five postdoctoral positions in the area of developmental epigenetics.

Interested in developmental epigenetics? So are we! Apply now to join us for your postdoc!

Multiple positions across multiple groups @mrc-lms.bsky.social

Projects spanning germline demethylation, gene regulation, genome architecture in development & disease 👇👇

lms.mrc.ac.uk/work/vacanci...

H2AK119ub Safeguards Against Ectopic Transcription Factor Mediated Gene Activation in the Developing Forebrain The PRC1 complex regulates developmental gene expression in mammals by ubiquitinating histones (H2AK119ub) and nucleating repressive chromatin interactions. Human genetic data and functional experimen...

Excited to share our hot-off-the-press @biorxivpreprint.bsky.social
that explores how PRC1-mediated H2AK119ub deposition safeguards lineage fidelity during forebrain development. Fantastic work by @lucyadoyle.bsky.social and our colleagues & collaborators. 🥳🧬🧠🔬
www.biorxiv.org/content/10.1...

Transcription and Chromatin UK is back! This time in Manchester, 17th-19th September. Send your abstract by 17th July for the opportunity to discuss your work with the UK RNA and epigenetics community, and with leading experts from abroad. Click the link below and spread the word!

Paper alert! I am really pleased to share the final version of the work led by Irène Amblard in the team on a regulatory switch controlling Cdx2 expression during posterior body development! #regulatorylogic #devbio @mrc-lms.bsky.social @imperialmed.bsky.social

Wissenschaftliche*r Mitarbeiter*in/ Postdoc (m/f/d) Chromatin ist nicht unbeweglich. Es handelt sich um ein hochdynamisches Material, dessen 3D-Struktur zentrale genomische Prozesse – von der Transkription bis zur DNA-Reparatur – steuert. Doch wie verhält sich Chromatin als Material – als Flüssigkeit, Feststoff oder viskoelastisches Gel –, um diese Funktionen in lebenden Zellen auszuführen? Ohne eine Antwort auf diese Frage können wir nicht vollständig verstehen, wie Chromatin bei Krankheiten gestört wird.

Postdoc🚨!

Come join our HFSP team to uncover how chromatin moves in cells and what this means for genome function! Great opportunity to combine single-cell genomics, live imaging and polymer physics in the unique mammalian retina with @andersshansen.bsky.social, Davide Michieletto & Sandra Tenreiro

And many congratulations to @eliasfriman.bsky.social and @hannahjuellig.bsky.social for their poster prizes!

The #EMBOenhanceropathies workshop was truly outstanding - such a wonderful community to be part of and exciting science from start to finish! Group photo in front of Hindsgavl Slot @edinburgh-uni.bsky.social @uoe-igc.bsky.social - we had a blast! 🧬

We caught up at the poster session this afternoon. Really exciting work! 🤩

🧬🎤 Very excited for the start of the EMBO Workshop in Enhancer Mechanics and Enhanceropathies this afternoon in Middelfart! Many thanks to the organizers @smandrup.bsky.social @radaiglesiaslab.bsky.social and Minna Kaikkonen for putting together an amazing programme! #EMBOenhanceropathies

I will be speaking at Fragile Nucleosome next week, join if you want to hear about the impact of endogenous retroviruses on human preimplantation development!

🎙️ Starting tomorrow - the 3rd International Symposium on Facial Genetics! I’m excited to hear the latest in the genetics of facial variation and functional interpretation of identified variants. What a fantastic line up of talks, posters, and lectures from Joanna Wysocka & @steinaerts.bsky.social !

Welcome! You are invited to join a webinar: The 3D Regulatory Genome: Gaining mechanistic insights into long-range gene regulation through synthetic biology approaches. After registering, you will rec... Join our guest speaker, Dr. Alvaro Rada-Iglesias, in this exciting seminar on the 3D Regulatory Genome, sponsored by Enhanced Genomics.

Really looking forward to @radaiglesiaslab.bsky.social's talk on "Gaining mechanistic insights into long-range gene regulation through synthetic biology approaches" in @enhancedgenomics.bsky.social's seminar series.

📅 June 5th 2025 tomorrow
⏰ 4pm GMT

Please join us:
us02web.zoom.us/webinar/regi...

Hidden Cell, Dark Genome meeting sheds light on pioneering cell and genetic research The Hidden Cell Dark Genome conference was held from 3-4 April, preceded by a public lecture on 2 April by writer and broadcaster Dr Kat Arney entitled ‘Enter the Dark Genome’.

Over 140 people attended the recent Hidden Cell, Dark Genome meeting organised by @hannahlong.bsky.social, Shipra Bhatia and @drphcb-uoe.bsky.social, and a lot of interest in a follow-up meeting to hear the next updates and discoveries. You can catch up on what was discussed here: edin.ac/3HtXpwA

HHMI Investigator Joanna Wysocka studies how, during early human development, our cells read and respond to DNA instructions to turn our genes on and off at the right times. 🧵

A great meeting this September in Birmingham to celebrate 10 years of the BCGB! There’s a stellar speaker list and a fantastic opportunity for students and early career researchers to network and present their work.
🧬 gene regulation - epigenetics - replication - genome stability - DNA repair 🔬

I had a wonderful time visiting the FMI @fmiscience.bsky.social yesterday - many thanks to @phlya.bsky.social for the kind invitation! It was great to connect with @lucagiorgetti.bsky.social, many lab members, and others across the institute. Life and science both look really fantastic in Basel!

Always a pleasure to return to Edinburgh and visit @uoe-igc.bsky.social, I had a fantastic day discussing science and meeting old and new friends. Many thanks to @hannahlong.bsky.social for the warm hospitality-even the sky was blue!

Such a pleasure to host you for the @uoe-igc.bsky.social seminar series @tsakiridis.bsky.social. It was great to hear about your latest exciting and impactful science and it was great to catch up! Thank you for visiting us and bringing the beautiful weather!

DNA-guided transcription factor interactions extend human gene regulatory code - Nature A large-scale analysis of DNA-bound transcription factors (TFs) shows how the presence of DNA markedly affects the landscape of TF interactions, and identifies composite motifs that are recognized by ...

A tour de force study from Taipale&Yin labs. It expands the vocabulary of the Regulatory Code by adding 1131 TF:TF composite motifs that are different from the individual TF motifs. The new composite motifs are enriched in cell-type specific elements and active in vivo
www.nature.com/articles/s41...

I’ll definitely plan to come again soon - would be lovely to catch up!

On my way to Oxford - thank you to @whitefishlab.bsky.social for the invitation to visit the Ludwig Institute! I still have such fond memories of my summer internship with Rich and Len Zon at the Harvard Stem Cell Institute! It’s been great keeping in touch across the years and many milestones 🐟🔬🧫

Many congratulations Wendy!

Junior / Assistant Specialist: Kim Lab, Developmental & Cell Biology University of California, Irvine is hiring. Apply now!

I am hiring for a research technician role in my new lab at UC Irvine studying how transcription factors control cell identity. If you know any graduating undergrads or postbacs looking for a position, please spread the word! Apply by May 9 for full consideration. recruit.ap.uci.edu/JPF09594

We released our preprint on the CREsted package. CREsted allows for complete modeling of cell type-specific enhancer codes from scATAC-seq data. We demonstrate CREsted’s robust functionality in various species and tissues, and in vivo validate our findings: www.biorxiv.org/content/10.1...

Deadline is Monday 28th.

Fully Funded PhD Studentship in Human Genetics, Genomics and Disease: Dissecting DNMT3B functions in Immunodeficiency-centromeric instability facial anomalies syndrome at University of Edinburgh on Fi... PhD Project - Fully Funded PhD Studentship in Human Genetics, Genomics and Disease: Dissecting DNMT3B functions in Immunodeficiency-centromeric instability facial anomalies syndrome at University of E...

Want to work with us on DNA methylation and rare genetic disease? Fully funded PhD project with deadline 16th May:
www.findaphd.com/phds/project...
Excited to collaborate with @hannahlong.bsky.social and Daria Bunina (@uoe-igc.bsky.social/@mdc-berlin.bsky.social).
Please share 🙏
#epigenetics