JASPAR: An open-access database of transcription factor binding profiles
JASPAR is the largest open-access database of curated and non-redundant transcription factor (TF) binding profiles from six different taxonomic groups.
JASPAR 2026 is out π
The new release massively expands the TF motif collections and adds a dedicated DeepLearning collection of motifs learned from deep learning models.
Database: jaspar.elixir.no
Paper (NAR): doi.org/10.1093/nar/...
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03.12.2025 14:43 β π 61 π 27 π¬ 1 π 0
Intro to Bedder β The Quinlan Lab
We are thrilled to announce the first official release (v0.1.8) of #π―π²π±π±π²πΏ, the successor to one of our flagship tool, #π―π²π±ππΌπΌπΉπ! Based on ideas we conceived of long ago (!), this was achieved thanks to the dedication of Brent Pedersen.
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02.12.2025 02:28 β π 281 π 139 π¬ 5 π 10
Donβt miss out on this opportunity- come and join us at the Oxford Organoid Hub working under the MRC-BHF REACT programme! If you love in vitro 3D models, the β€οΈ and regenerative therapies, this is for you - apply by 18 Dec @oxforddpag.bsky.social @idrm.ox.ac.uk @rdm.ox.ac.uk
30.11.2025 23:02 β π 10 π 8 π¬ 0 π 0
MRC four-year International PhD programme: Human Genetics, Genomics and Disease | IGC Graduate Research & Training | Institute of Genetics and Cancer
Applications now open.
Exciting opportunity to work on a collaborative PhD project with Duncan and myself modeling ICF1 syndrome in human stem cell models π§«
@sproullab.bsky.social
@uoe-igc.bsky.social
Applications are open for the MRC PhD programme in Human Genetics, Genomics and Disease at the University of Edinburgh!
25.11.2025 10:47 β π 4 π 0 π¬ 0 π 0
Project 2: Use human ES cells to determine exactly how DNMT3B mutations cause ICF1 syndrome. Collaboration with @hannahlong.bsky.social:
institute-genetics-cancer.ed.ac.uk/igc-graduate...
Deadline 11th January 2026
This scheme is flexible if you are interested in other projects.
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25.11.2025 09:15 β π 7 π 5 π¬ 2 π 0
π¨ Multiple #PhD opportunities for lab or computational applicants. Do you want to understand the molecular basis of #epigenetic dysfunction in human disease?
Come work with our group at the fantastic, collaborative @uoe-igc.bsky.social in a beautiful, liveable city.
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Please repost π
25.11.2025 09:15 β π 20 π 17 π¬ 1 π 2
BRAIN-MAGNET: A functional genomics atlas for interpretation of non-coding variants
BRAIN-MAGNET, a convolutional neural network trained on 148,198 functionally tested
non-coding regulatory elements, predicts enhancer activity directly from DNA sequence
and identifies nucleotides ess...
Very pleased to share our latest paper published in Cell:
BRAIN-MAGNET: A functional genomics atlas for interpretation of non-coding variants: Cell www.cell.com/cell/fulltex...
@cellpress.bsky.social, @cp-cell.bsky.social, @ruizhideng.bsky.social #enhancer
here is a thread about our findings:
20.11.2025 09:38 β π 12 π 9 π¬ 2 π 2
Neanderthal DNA reveals how human faces form
Subtle genomic variations between humans and Neanderthals provide clues to how DNA shapes our facial features.
Researchers have identified gene-regulatory variants that might have contributed to Neanderthalsβ beefy jaws β offering a window on how the human face developed
go.nature.com/3Ke6StJ
20.11.2025 17:07 β π 33 π 7 π¬ 0 π 3
Congratulations!
19.11.2025 11:56 β π 2 π 0 π¬ 1 π 0
π¨Reposts appreciatedβΌοΈIf I had read this PhD offer five years ago, I wouldnβt have hesitated for a second to apply π
Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social π§¬β¨
#PhD #3DGenome
15.11.2025 09:52 β π 35 π 37 π¬ 0 π 3
Join us for our free inaugural lecture & drinks reception. @jorisveltman.bsky.social will talk about the genetic causes of rare disorders such as reproductive disorders & Charlie Lees will tell the 20βyear story of change in IBD.
More info & registerπ bit.ly/3J766hJ
@cmvm-edinburghuni.bsky.social
05.11.2025 10:28 β π 3 π 1 π¬ 0 π 1
Neanderthal DNA enhances our understanding of face development
This Research Highlight showcases the work from Hannah Long @hannahlong.bsky.social, Kirsty Uttley @kirstyuttley.bsky.social, Hannah JΓΌllig @hannahjuellig.bsky.social and colleagues: journals.biologists.com/dev/article/...
10.11.2025 13:04 β π 21 π 7 π¬ 2 π 2
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
05.11.2025 17:17 β π 205 π 77 π¬ 6 π 11
Enjoy the start of this new adventure! And hopefully Iβll see you soon in Europe βΊοΈ
10.11.2025 16:20 β π 0 π 0 π¬ 0 π 0
Many congratulations Wendy, and to the whole team! Excited to see what you discover π§¬
10.11.2025 16:05 β π 0 π 0 π¬ 0 π 0
Thanks Rob - so pleased to see the first paper from the lab published today βΊοΈ
10.11.2025 15:54 β π 1 π 0 π¬ 0 π 0
Left to right: Kirsty Uttley, Hannah Long and Hannah JΓΌllig at the Institute of Genetics and Cancer, overlooking the city of Edinburgh. Photo credit: Connor Warnock.
To learn more about how this story developed and the researchers behind it, we talked to co-first authors Kirsty Uttley and Hannah JΓΌllig, as well as corresponding author, Hannah Long
doi.org/10.1242/dev....
10.11.2025 13:04 β π 12 π 4 π¬ 0 π 0
Excited to share our new paper out today in Development! Check out Hannahβs fantastic post below for a summary of the findings β¨
journals.biologists.com/dev/article/...
10.11.2025 14:37 β π 13 π 1 π¬ 0 π 0
Development | The Company of Biologists
Many congratulation to first authors @kirstyuttley.bsky.social and @hannahjuellig.bsky.social who led this work. And a big thank you to co-authors, our funders and everyone who supported this project.
journals.biologists.com/dev/article/...
@uoe-igc.bsky.social
@edinburgh-uni.bsky.social
@ukri.org
10.11.2025 12:50 β π 6 π 0 π¬ 0 π 0
We suggest that increased activity of the Neanderthal EC1.45 regulatory element may have impacted SOX9 expression during development to shape lower jaw morphology.
More details in the paper - including overexpression of SOX9 in EC1.45-active cells and single cell RNA-seq to define key cell types.
10.11.2025 12:45 β π 5 π 0 π¬ 1 π 0
We observed that the Neanderthal EC1.45 enhancer was more active than the human enhancer in a region of the developing face adjacent to the forming lower jaw.
10.11.2025 12:45 β π 6 π 0 π¬ 1 π 0
Quantitative spatial and temporal assessment of regulatory element activity in zebrafish
A new method for quantitative assessment of altered regulatory potential of human enhancers bearing disease-associated mutations using live imaging in zebrafish embryos.
To explore the impact of these genetic differences on gene regulatory activity, we leveraged a dual fluorescent reporter assay in zebrafish called Q-STARZ that enables live imaging of regulatory activity for two enhancers concurrently during development.
elifesciences.org/articles/65601
10.11.2025 12:45 β π 4 π 0 π¬ 1 π 0
To explore this question, we turned to recent human evolution and single nucleotide changes in EC1.45 which are found uniquely in the Neanderthal genome. From looking at the fossil record, Neanderthal jaws were very distinct to our own. Could changes in EC1.45 perhaps contribute to this difference?
10.11.2025 12:45 β π 4 π 0 π¬ 1 π 0
One of these enhancers (EC1.45) lies a huge 1.45 megabases upstream of the SOX9 gene, yet is crucial for its expression during facial formation. We reasoned that smaller genetic changes within EC1.45 may tweak its activity and cause more subtle impacts to facial shape.
10.11.2025 12:45 β π 7 π 0 π¬ 1 π 0
In our previous work, we explored how chromosomal translocations and large deletions upstream of the SOX9 gene may impact facial development in patients with Pierre Robin sequence (PRS). We identified two candidate enhancers active in facial progenitor cells.
doi.org/10.1016/j.stem.2020.09.001
10.11.2025 12:29 β π 8 π 1 π¬ 1 π 0
π£ Paper alert!
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
10.11.2025 11:11 β π 116 π 46 π¬ 7 π 6
We recently reported that promoter competition can contribute to the robust insulation of gene regulatory domains (www.nature.com/articles/s41...).
We now offer a 4-years PhD contract to investigate whether the dirsuption of this regulatory mechanism can lead to congenital defects. More details π
06.11.2025 18:37 β π 16 π 14 π¬ 0 π 0
π₯This Wednesday , in #FragileNucleosome seminar, we are excited to host @hannahlong.bsky.social and @jeffvierstra.bsky.social to tell us about amazing work they are doing!
ποΈRegister here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...
03.11.2025 12:03 β π 20 π 12 π¬ 0 π 0
β‘β‘Excited to announce I'll be starting my lab at the Max Planck Institute of Molecular Genetics (@molgen.mpg.de) in Berlin in December! Leaving sunny California to join a fantastic environment with colleagues who do super cool work.
π¬π¦ I'm hiring at all levels! π¬π¦ Check: www.molgen.mpg.de/fueyo-lab
06.10.2025 13:46 β π 86 π 26 π¬ 3 π 2
Investigating chromatin states in acute myeloid leukemia in mice and humans; Postdoc in the Childhood Leukemia Group at the Department of Biomedicine, University of Basel, Switzerland.
Wandering around the complexities of genome regulation and anything connected to it π§¬
A dedicated fan of smiling out loud!
Currently at Sorbonne UniversitΓ©
Scientist in progress. Post-Doc at UMass Chan Medical School. Working with spatial epigenomics.
Biochemist fascinated by visualizing biological processes with the finest spatiotemporal detail; Understand the human immune system to guide novel approaches for combating viral infections and cancer; Postdoc at CissΓ© Lab / MPI-IE
Research Associate at @institutrb π§¬. Researching into #ComputationalBiology & #Bioinformatics. Passionate about #RegulatoryGenomics & #ComparativeGenomics π§ͺ. Opinions are my own π.
Group leader at the Max Planck Institute for Molecular Genetics π¬π§¬π§ͺπ§«ππ€. Former UCSF, MPI Freiburg, Bilkent Uni & METU. Diversity is power.
https://www.molgen.mpg.de/Genome-Regulation/Bulut-Karslioglu-lab
PhD researcher at MPI-EVA, interested in population genetics, archaeology, Neandertals and Early Modern Humans
Professor, Department of Medicine and McDonell Genome Institute @ Washington University. Specializing in Bioinformatics, Genomics, and Cancer. http://griffithlab.org/
An open-access @natureportfolio.bsky.social journal publishing high quality primary research, reviews and commentary in all areas of the biological sciences since 2018.
https://www.nature.com/commsbio/
A journal dedicated to publishing the latest advances across all areas of cell biology. Part of @natureportfolio.nature.com
nature.com/ncb/index.html
A Reviews journal from SpringerNature. Timely Review articles, Comments and Highlights of the latest research in molecular cell biology. https://www.nature.com/nrm/
Nature Genetics is a monthly journal publishing high impact research in genetics and genomics. Part of @natureportfolio.bsky.social
Repost/like=interesting/relevant, not necessarily endorsement.
Publishing reviews and commentaries across the fields of genetics and genomics. Part of Springer Nature and Nature Portfolio.
https://www.nature.com/nrg/
A scientific journal publishing cutting-edge methods, tools, analyses, resources, reviews, news and commentary, supporting life sciences research. Posts by the editors.
Nature Communications is an open access journal publishing high-quality research in all areas of the biological, physical, chemical, clinical, social, and Earth sciences.
www.nature.com/ncomms/
Research, news, and commentary from Nature, the international science journal. For daily science news, get Nature Briefing: https://go.nature.com/get-Nature-Briefing
Nature Structural & Molecular Biology publishes top-quality research providing insight into how molecular components work together in biological processes.
https://www.nature.com/nsmb/
Nature Portfolioβs high-quality products and services across the life, physical, chemical and applied sciences is dedicated to serving the scientific community.
Interested in chromatin dynamics during mammalian development
