Josh

Multigenerational cell tracking of DNA replication and heritable DNA damage - Nature A multigenerational single-cell tracking approach provides a framework to dissect phenotypic plasticity at the single-cell level, offering insights into cellular processes that may resemble early even...

Delighted to share that the results of my main postdoc project are now published in @nature.com

🔗 doi.org/10.1038/s415...

Watch a major campaign being born.

Citrulline regulates macrophage metabolism and inflammation to counter aging in mice Citrulline acts as an endogenous metabolite antagonist to aging and inflammation by regulating mTOR-HIF1α-glycolysis pathway.

#WeekendRead! #LiveForever! Zhu &co show @ Science Advances that Citrulline decreases with aging & that its long-term administration leads to protective effects by inhibiting mTOR & glycolysis in macrophages, countering inflammaging
www.science.org/doi/10.1126/...

Kinda hard to see a free and fair 2028 election where she doesn’t win by a lot.

Twenty Lessons, read by John Lithgow Key selections from On Tyranny, for viewing and sharing

"On Tyranny" is a #1 NYT bestseller again. I wish the moment were different. But I’m glad the book is useful. And grateful for all the kind words about putting the 20 lessons to work.
snyder.substack.com/p/twenty-les...

I hope everyone realizes that scrubbing historical references from web sites is no different than burning books

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Decrypting the molecular basis of cellular drug phenotypes by dose-resolved expression proteomics - Nature Biotechnology Proteome-wide measurements of dose–response curves for 144 drugs reveal drug mechanisms of action.

Proteome-wide measurements of dose–response curves for 144 drugs reveal drug mechanisms of action go.nature.com/4a9lMs8
rdcu.be/egMl1

Exciting! Can’t wait to read it @eeschenberg.bsky.social

You can still register for today's talk in our Lecture Series! Just click on this link to join the talk and discussion at 4pm (CET) on zoom: rotorub.wordpress.com/roto-lecture...
#HPBio #PhilSci #PhilMed

In years to come, the people who did this will be the ones who will go to jail.

Late #WeekendRead: We describe a novel reporter to visualize endogenous #inflammasome assembly. Suitable for cell lines, primary cells, and tissues as well as quantification by #microscopy and #flowcytometry. Happy to share. www.biorxiv.org/content/10.1...

Simulating 500 million years of evolution with a language model More than 3 billion years of evolution have produced an image of biology encoded into the space of natural proteins. Here, we show that language models trained at scale on evolutionary data can genera...

In a new Science study, researchers present ESM3, a protein language model that enables the programmed generation of protein structure and sequence in response to user prompts.

Learn more: scim.ag/40l2z3J

From EARTHSEED: THE BOOKS OF THE LIVING Choose your leaders with wisdom and forethought. To be led by a coward is to be controlled by all that the coward fears. To be led by a fool is to be led by the opportunists who control the fool. To be led by a thief is to offer up your most precious treasures to be stolen. To be led by a liar is to ask to be told lies. To be led by a tyrant is to sell yourself and those you love into slavery.

from “Parable of the Talents” by Octavia Butler

This is figure 2, which shows z-scored voxel-wise PET images of the exceptional resilience mutation carrier and of averaged symptomatic mutation carriers relative to non-carriers.

A study in Nature Medicine of a rare case of asymptomatic dominantly inherited Alzheimer’s reveals confined tau pathology and unique proteomic features, highlighting potential resilience mechanisms decades beyond expected onset. https://go.nature.com/41fiZfS 🔒

BREAKING: VIRUS FROM NEVADA DAIRY WORKER WITH BIRD FLU HAS THE SAME GENETIC MUTATION seen in the Nevada cows – a change of PB2 D701N that has previously been assoc with more efficient virus replication in ppl & mammals.

CDC told Fortune that the D1.1 variant in this worker is the same strain of

Mike Lee tweets "name a fascist dictator whose agenda entailed limit the size cost and power of government." Elon quote tweeted it with a laugh emoji and an arrow hitting a bullseye emoji.

Perhaps if he had not spent so much time playing video games so that he could be the #1 video game player he would know that the answer to this question is "All of them."

Hello #Bluesky! Let's talk diseases, medicine, history, biology, and whatever else is on your mind/bookshelf.

“Like and Subscribe”: A Compendium of Infectious Diseases Audio Podcasts Abstract. In little more than 15 years, the podcast has gone from being virtually unknown to becoming a multibillion-dollar industry. There are an estimate

A peer-reviewed guide to infectious disease podcasts?! And @tpwky.bsky.social made the list?! Yes please!!

academic.oup.com/ofid/article...

This figure shows the potential mechanisms of immune-mediated liver injury from checkpoint inhibitors, showing key steps in monocyte recruitment and activation, CD8+ T cell recruitment and activation, and hepatocyte apoptosis

#Immunotherapy has changed the treatment landscape for patients with cancer. This REVIEW explores immune-mediated liver injury from checkpoint inhibitors, from mechanisms to management
www.nature.com/articles/s41...

#Sharedit link: rdcu.be/d5IOa

#Oncsky #Gastrosky #Liversky

Last time I checked, nobody voted for the richest man in the world to run the federal government.

Noncanonical role of ALAS1 as a heme-independent inhibitor of small RNA–mediated silencing microRNAs (miRNAs) and small interfering RNAs (siRNAs) are 21- to 22-nucleotide RNAs that guide Argonaute-class effectors to targets for repression. In this work, we uncover 5-aminolevulinic acid synt...

In this week's @science.org from @lucksmith.bsky.social and colleagues @mskcancercenter.bsky.social | Noncanonical role of ALAS1 as a heme-independent inhibitor of small RNA–mediated silencing
#RNA #microRNA #miRNA #siRNA #argonaute🧬🧪
www.science.org/doi/10.1126/...

People paying attention to the drone stuff, am I missing something or is there no actual evidence of large drones?

‘Unofficial co-president’: Sen. Warren presses President-elect Trump for answers on Elon Musk’s role Warren is demanding answers from Trump on Musk’s role as a top advisor in his incoming administration, expressing concerns in a letter about the billionaire’s “massive conflicts of interest.”

The American people deserve to know whether an “unofficial co-president” is advancing policies that are good for the country or just good for his own bottom line.
www.boston25news.com/news/local/u...

Molecules of the year 2024 C&EN editors highlight some of our favorite molecules from the past year

α⁠-⁠ʟ⁠-⁠Cyclodextrin has won @cenmag.bsky.social 2024 Molecule of the year! cen.acs.org/synthesis/Mo...

Check out the research paper published in @naturesynthesis.bsky.social earlier this year www.nature.com/articles/s44...
#chemsky

❓ Do you know what the anterior hypothalamic nucleus (AHN) does? No? Neither did we! 🧠

In a new preprint from the Cai Lab, learn how we discovered the AHN’s central role in regulating stress vulnerability.

Read the paper here: www.biorxiv.org/content/10.1... (1/6)

Since the day it was created, the CFPB has been under attack because financial fraudsters don't like having a cop on the beat.

But it has kept its head down, done its work, and returned about $20 billion to consumers who got cheated—making our government work for working people.