Jakob Nikolas Kather

Artificial intelligence agents in cancer research and oncology - Nature Reviews Cancer Artificial intelligence agents are autonomous systems that use large language models to reason and as such can perform complex, multistep tasks with minimal human oversight. This Review by Truhn et al. discusses how these agents — which have already been implemented in several industries — could transform cancer research and oncology, and looks at the challenges that need to be addressed before they can be efficiently and safely used.

#REVIEW 🚨

#AI agents perform complex tasks with minimal human oversight. This Review by @jnkt.bsky.social et al. discusses how AI could transform oncology & the challenges to address for efficient & safe use.


👇 📖

Our review on AI agents in cancer research and oncology is out in @natrevcancer.nature.com. Already partly outdated at publication, but hopefully still useful. With Daniel Truhn, Shekoofeh Azizi, James Zou, Leonor Cerda-Alberich, Faisal Mahmood -> www.nature.com/articles/s41...

I've overhauled my puzzle level generation so a level is now "grown" like cell tissue in a triangle tessellation. New elements can be inserted anywhere, and the whole level deforms to make room. This makes it easier to control topology and create paths that loops around areas.
#ProcGen #GameDev

EU told to choose between ‘money today or blood tomorrow’ as leaders debate giving Russian assets to Ukraine – Europe live European leaders meet in Brussels as Poland’s Donald Tusk issues warning to fellow EU states The European Council president António Costa is clear that the talks will go on for as long as it’s needed to get an agreement. He seeks to maintain a largely neutral position, but says: Continue reading...

EU told to choose between ‘money today or blood tomorrow’ as leaders debate giving Russian assets to Ukraine – Europe live

Kirill Dmitriev @kadmitriev g ... EU's fatal mistake: choosing censorship over debate, ideology over reality, mass migration over security and green dogma over industry. Secretary Marco Rubio © @SecRubio • 5. Dez. The European Commission's $140 million fine isn't just an attack on @X, it's an attack on all American tech platforms and the American people by foreign governments. The days of censoring Americans online are over. %% Vorgeschlagene kollektive Anmerkungen bewerten →

Christopher Landau v ® @DeputySecState g ... My recent trip to Brussels for the @NATO Ministerial meeting left me with one overriding impression: the US has long failed to address the glaring inconsistency between its relations with NATO and the EU. These are almost all the same countries in both organizations. When these countries wear their NATO hats, they insist that Transatlantic cooperation is the cornerstone of our mutual security. But when these countries wear their EU hats, they pursue all sorts of agendas that are often utterly adverse to US interests and security-including censorship, economic suicide/climate fanaticism, open borders, disdain for national sovereignty/promotion of multilateral governance and taxation, support for Communist Cuba, etc etc. This inconsistency cannot continue. Either the great nations of Europe are our partners in protecting the Western civilization that we inherited from them or they are not. But we cannot pretend that we are partners while those nations allow the EU's unelected, undemocratic, and unrepresentative bureaucracy in Brussels to pursue policies of civilizational suicide. Post übersetzen 12:53 nachm. • 6. Dez. 2025 • 4,2 Mio. Mal angezeigt

JD Vance v @JDVance X.com Rumors swirling that the EU commission will fine X hundreds of millions of dollars for not engaging in censorship. The EU should be supporting free speech not attacking American companies over garbage.

畢 Angeheftet Elon Musk ® X @elonmusk| Abonnieren The EU should be abolished and sovereignty returned to individual countries, so that governments can better represent their people Post übersetzen| 1:17 nachm. • 6. Dez. 2025 • 12,4 Mio. Mal angezeigt 0 ... • 13.213 | t? 19.336 0107.967| 丫 贝 2.989| 企 Dmitry Medvedev @MedvedevRussiaE • 2 Std. Exactly • 171ゼ］ 149 01.736 Y lit 24.738 贝企

US and Russian officials participated in a coordinated attack on Europe which saw thousands of bots spread disinformation and terroristic rhetoric against the European Union.

Now out in @natcomputsci.nature.com: "Adaptive validation strategies for real-world clinical artificial intelligence"

It was a pleasure working on this piece with @jnkt.bsky.social, excited to finally see it published!

#medicalAI #clinicalAI #digitalhealth #translationalresearch

Valuable insights on the implementation of #AI in oncology research by Prof. @jnkt.bsky.social at the #ESMOGI25 Young Oncologists session!
#ESMOYOC @myesmo.bsky.social

Figure 1. Experimental Outline to Estimate the Impact and the Clinical Representation of Labeled Pathology Slides.

Figure 2. Incorrect Labels on Whole-Slide Images Reduce the Accuracy of Vision–Language Models Regardless of Task.

Figure 3. Misleading Watermarks Lead to a Loss in Accuracy of Tissue-of-Origin Prediction.

Case Study by J. Clusmann et al.: Incidental Prompt Injections on Vision–Language Models in Real-Life Histopathology nejm.ai/4mrSoEW

@janclusmann.bsky.social #AI #MedSky #DigitalHealth

Trees on Paris

According to the City of Paris, in the last 10 years 150K trees have been planted & 45ha of parks created in the already hot city, all intended to not only improve quality-of-life today, but also help the city adapt to & manage summer heatwaves of 50℃ (122F) by 2050.

They’ll be planting a lot more.

Development and validation of an autonomous artificial intelligence agent for clinical decision-making in oncology - Nature Cancer Ferber et al. present an autonomous artificial intelligence agent system for deployment of specialized medical oncology computational tools, validating their system across various clinical scenarios r...

very happy to share our new paper on LLM-based tumor board agents. Submitted August 2024, published in @natcancer.nature.com today ☺️ Led by Dyke Ferber www.nature.com/articles/s43...

Incidental Prompt Injections on Vision–Language Models in Real-Life Histopathology Vision–language models (VLMs) can analyze multimodal medical data. However, a significant weakness of VLMs is their susceptibility to prompt injection attacks. Here, the model receives conflicting ...

Excited to share our new publication in @ai.nejm.org „Incidental Prompt Injections on Vision-Language Models in Real-Life Histopathology“. Important work together with our amazing colleagues @janclusmann.bsky.social @jnkt.bsky.social @markuseckstein3.bsky.social et al. ai.nejm.org/stoken/defau...

Photo credits: Reuben Docea

Congrats to Dominik Rivoir on successfully defending his PhD!🎓🎉 Best wishes ahead!
A shout-out to the PI, @stefaniespeidel.bsky.social and a heartfelt thanks to the committee - Alejandro Granados, @jnkt.bsky.social, Stefan Gumhold, Bjoern Andres.
#CeTI, @dkfz.bsky.social, @tudresden.bsky.social

EASL2025 Poster: "WED-254 Deeplearning allows prediction of portal hypertension from liver biopsies"

Proud to present our group's work on utilizing deeplearning🤖🧠 to predict portal hypertension from liver biopsies🔬 in patients with ACLD!

www.journal-of-hepatology.eu/article/S016...

@reibergerthomas.bsky.social
Thanks to Team @jnkt.bsky.social for the support!
#AI #liver #hepatology

ChatGPT when I ask questions about breast cancer treatment 🙄

Meta-synthesis reveals interconnections among apparent drivers of insect biodiversity loss Abstract. Scientific and public interest in the global status of insects has surged recently; however, understanding the relative importance of different s

🦋📉 Insect populations down 75% in <30 years

A new study maps 3,385 connections between stressors behind insect decline. Agricultural intensification tops the list – but many impacts remain overlooked.

🔗 doi.org/10.1093/bios...

#SciComm #Biodiversity #Insects 🧪

A random photo which I posted on Google Maps years ago has 1.3M views now... approximately 1000x more than most of our scientific publications 😭

oh good point, sorry! Openreview is not public for ACL. The quote is the last line from the meta-review for our submission . Unfortunately the meta-review mischaracterizes our submission. To be fair, I think controlled LLM use is a good idea (see: arxiv.org/abs/2504.09737), but not in this way.

OpenReview

Our submission for @aclmeeting.bsky.social seems to have been reviewed by ... Claude plus a lazy human 🙄🙄🙄 "RetryClaude can make mistakes. Please double‑check responses." It is not just a breach of conference policy, but also it is a poor quality review... openreview.net/forum?id=KiY... #ACL2025NLP

We are looking to hire a PostDoc to develop AI multimodal foundation models for uncovering cancer metastasis mechanisms and identifying targetable biomarkers for patient treatment. 🩻🔬🧬 



If you’re interested, please apply here: bit.ly/42nY62u

#KatherLab #EKFZ #TUDresden #ClinicalAI #AI #JobPost

✮ Kather Lab is hiring PostDocs & Software Engineers!

☞ Strong Python & PyTorch skills, GitHub experience, and interest in LLMs & computational pathology required. 



Apply here╰( ͡° ͜ʖ ͡° )つ──☆*・ﾟ: bit.ly/42nY62u

happy weekend from our research group at @tudresden.bsky.social, credit to @zcarrero-katherlab.bsky.social

Happy to share our latest paper in @ai.nejm.org, led by Isabella Wiest: "Deidentifying Medical Documents with Local, Privacy-Preserving Large Language Models: The LLM-Anonymizer" ai.nejm.org/doi/full/10....
You can use our open source tool with local LLMs to robustly de-identify medical documents.

graph of NIH basisfor new drugs

A pie graph worth keeping in mind as the NIH budget plummets jamanetwork.com/journals/jam... for 356 new FDA drugs approved

Photo of Prof. Jakob N. Kather sitting on a desk with a laptop on his lap. A computer can also be seen on the table.

The DECIPHER-M research project uses #ArtificialIntelligence (AI) to further understand the spread of #cancer cells based on routine clinical data. 🔬 The aim is to improve treatment options using a multimodal foundation model.
ℹ️ tu-dresden.de/tu-dresden/n...

We have open Postdoc / PhD student positions in computational pathology and agentic AI, based in 🇩🇪🇪🇺 Ideally with a CS background, but we do 🧡 biologists with self-taught Python and ML skills

Mike spotted this before the rest of us. 🫡

Publications from 2025 are shared more on Bluesky than on X/Twitter.

Beyond ChatGPT and digital pathology algorithms, @jnkt.bsky.social reviews current and future states for deep learning artificial intelligence in breast oncology #SGBCC2025

Just got an email from the Fulbright Association. As of right now, funding has been cut off to 12,500 US citizens currently abroad and and more than 7,400 foreigner scholars and students in the United States

What a tour de force!👨‍⚕️ @jnkt.bsky.social is really a trailblazer in the use of AI 🤖 in oncology practice and research.

TLDR: As an oncology community, we really need to keep abreast with the rapidly evolving (improving!) developments in AI.

Large language models
LLM “agents”
etc

#ESMOTAT25

I wish more prominent scientists would speak out about what is happening under Trump.

Yes, there is a real threat to one's livelihood of doing so. Being a scientist has been my lifelong dream, but there's honest work I can do outside of science, and I'd rather do that than serve the current regime.