Stefan Isaac

I'm thrilled to share that our story is now out in Science Advances! 🎉 We use quantitative imaging to map the mito central dogma, define translation hubs in the mitochondrial matrix, and show that they're replaced by Mitochondrial Stress Bodies (MSB) when mtRNA processing is perturbed 1/4

Nobel laureate: I owe America my success. Today, its scientific future is in danger | CNN Dr. Ardem Patapoutian says he watches “with deep sadness as the United States’ remarkable scientific enterprise, which took generations of hard work and national investment to build, faces a concerted...

Published an op-ed for @cnn.com: “Nobel laureate: I owe America my success. Today, its scientific future is in danger.”
A personal reflection on what’s at stake as science funding gets slashed. I’d be grateful if you could amplify both in and beyond the science world.
www.cnn.com/2025/04/09/h...

Well. The greying beard is accurate.

NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.

NIH is the best investment there is.

www.forbes.com/sites/michae...

Engineering mtDNA deletions by reconstituting end joining in human mitochondria Recent breakthroughs in the genetic manipulation of mitochondrial DNA (mtDNA) have enabled precise base substitutions and the efficient elimination of…

Combining bacterial end joining with programmable nucleases, we induced mtDNA deletions in human cells at varying heteroplasmy and examined their metabolic and cellular effects. Simple tool to apply across any cell type and engineer pathogenic mtDNA deletions. www.sciencedirect.com/science/arti...

Exclusive: NIH to terminate hundreds of active research grants Studies that touch on LGBT+ health, gender identity and DEI in the biomedical workforce could be terminated, according to documents obtained by Nature.

“It’s extremely alarming that grants that have been vetted by the scientific community and deemed important and impactful to understand the world are now being cancelled because of political ideology,” says @lkfazio.bsky.social.

“This is direct censorship of scientific research.”

Secretary McMahon: Our Department's Final Mission The Department of Education’s role in this new era of accountability is to restore the rightful role of state oversight in education and to end the overreach from Washington.

Everyone should be alarmed by McMahon's "Final Mission" for the DoE: "restoring patriotic education" and aligning education with "workforce needs." On track to completely eliminate critical thinking/intellectual curiosity to focus on nationalist ideology. Among countless other issues.

If you are interested in mitochondria, Nashville is the place to be June 1-5. Check out this FASEB meeting. Please RT. events.faseb.org/event/mitoch...

If it messes with submission by the deadline be sure to submit a ticket and put it in your letter. Maybe all the more experienced people already know this. I had issues with my MIRA submission last month and that’s what the NIH help desk person instructed me to do.

Last weekend I wrote a letter to the editor to my hometown newspaper as part of the Sciencehomecoming.com movement.

I will share my letter in this thread, and share my approach to lower the activation energy for y'all to join me.

🧪 #microsky