bioRxiv Pathology

Chronic kidney disease exacerbates hyperlipidemia and atherosclerosis via miR-148a-3p targeting SIK1/AMPKα1 in liver https://www.biorxiv.org/content/10.1101/2025.10.08.681287v1

Astrocytic Cathepsin D truncates α-synuclein and promotes Lewy neurite-like aggregation in neurons https://www.biorxiv.org/content/10.1101/2025.10.03.680233v1

Effect of fungicides and cultivar on cereals to T. afroharzianum ear infection in the field related to fungicide treatment and crop cultivar https://www.biorxiv.org/content/10.1101/2025.10.06.680620v1

Hypertrophic bone proliferation at enthesis induced by unilateral injection of botulinum toxin in masticatory muscles in adult rats is characterized by chondrocyte proliferation without inflammatory process at enthesis https://www.biorxiv.org/content/10.1101/2025.10.03.680271v1

A noncanonical TNL immune hub defines separable recognition and signaling modules for clubroot resistance https://www.biorxiv.org/content/10.1101/2025.10.03.680381v1

Single-cell spatial mapping reveals dynamic bone marrow microarchitectural alterations and enhances clinical diagnostics in MDS https://www.biorxiv.org/content/10.1101/2025.10.02.680138v1

Histology-guided 3D virtual staining of microCT-imaged lung tissue via deep learning https://www.biorxiv.org/content/10.1101/2025.10.02.678959v1

PDE3A2 modRNA Fine-Tunes Nuclear cAMP Microdomains and Reverses Pathological Cardiac Hypertrophy https://www.biorxiv.org/content/10.1101/2025.09.30.679675v1

Late-Talking Children Talk More? A Machine Learning Approach to Speech Act Analysis in Early Childhood https://www.biorxiv.org/content/10.1101/2025.09.30.679667v1

Development of a High-Throughput Screening Method for Anti-NNV Drugs https://www.biorxiv.org/content/10.1101/2025.09.30.679469v1

ATG4D loss leads to late-onset cardiomyopathy and stress-induced heart failure in mice, and its repression marks maladaptive cardiac remodeling in humans https://www.biorxiv.org/content/10.1101/2025.09.29.678527v1

BIN1 overexpression rescues cardiac but not skeletal muscle defects in a mouse model of caveolinopathy https://www.biorxiv.org/content/10.1101/2025.09.26.678914v1

Deletion of Cd248 in Postn positive myofibroblast Fails to Attenuate Cardiac Remodeling and Fibrosis in a Murine Model of Pressure-Overload Cardiomyopathy https://www.biorxiv.org/content/10.1101/2025.09.26.678917v1

Hyperactivated Glycolysis Drives Spatially-Patterned Kupffer Cell Depletion in MASLD https://www.biorxiv.org/content/10.1101/2025.09.26.678483v1

Phenomenological model of transthyretin stabilization https://www.biorxiv.org/content/10.1101/2025.09.25.678455v1

The fate of melanocytes and the disorganization of basement membrane in a guinea pig model of Rhododendrol-induced chemical vitiligo https://www.biorxiv.org/content/10.1101/2025.09.24.678429v1

N-acetyl-phenylalanine induces hepatic steatosis in MASLD by disrupting ER-mitochondria calcium coupling and mitochondrial lipid oxidation https://www.biorxiv.org/content/10.1101/2025.09.24.678188v1

Lzp Ablation Ameliorates Dyslipidemia and Suppresses Atherosclerosis by Reducing Circulating Apolipoprotein B-Containing Lipoproteins https://www.biorxiv.org/content/10.1101/2025.09.24.678175v1

TLR4 promotes liver fibrosis in metabolic dysfunction-associated steatohepatitis by a mechanism independent of hepatocytes and inflammatory cells https://www.biorxiv.org/content/10.1101/2025.09.25.678670v1

Repurpose of Ritlecitinib Reduces Neointima Formation and Enhances Endothelial Recovery Following Vascular Injury https://www.biorxiv.org/content/10.1101/2025.09.23.678172v1

Mitochondrial Dysfunction in Endothelial Cells Drives Greater Vascular Impairment in Females with Diabetes-Associated Peripheral Artery Disease https://www.biorxiv.org/content/10.1101/2025.09.22.677648v1

Alkalinized Filtered Water Induces Changes in the Gut Microbiome in Inflammatory Bowel Disease. https://www.biorxiv.org/content/10.1101/2025.09.19.677298v1

Probing the activity of cysteine cathepsins in inflammatory bowel diseases https://www.biorxiv.org/content/10.1101/2025.09.18.677249v1

Hepatitis E ORF2 blocks trophoblast autophagy to induce miscarriage via LC3B binding rather than PI3K/Akt/mTOR pathway suppression https://www.biorxiv.org/content/10.1101/2025.09.19.677307v1

An immunocompetent murine model of virus-elicited liver fibrosis and hepatocellular carcinoma https://www.biorxiv.org/content/10.1101/2025.09.19.677076v1

Intermittent Hypoxia Drives Early Metabolic Dysfunction in Brown Adipose Tissue https://www.biorxiv.org/content/10.1101/2025.09.18.676807v1

Interpretable Deep Learning Reveals Biologically Relevant Spatial Gene Expression Patterns in Lung Tumors and their Microenvironment https://www.biorxiv.org/content/10.1101/2025.09.17.674367v1

Mitochondrial stress in Fabry disease https://www.biorxiv.org/content/10.1101/2025.09.16.676526v1

Sex differences in alpha galactosidase protein processing and its impact on disease severity in Fabry disease https://www.biorxiv.org/content/10.1101/2025.09.16.676554v1

The Impact of Formic Acid Treatment on Brain Tissues for Prion Inactivation https://www.biorxiv.org/content/10.1101/2025.09.16.676643v1