Nicolas Buchon

Infectious bacteria, but not the microbiota, induce a NOX-ATM-cytokine pathway that controls epithelial turnover Nagy et al. identify a NOX-ATM-cytokine signaling axis in the Drosophila gut that is activated by infection independently of DNA damage. This pathway promotes enterocyte loss, cytokine production, and...

Our new study is out in Cell Reports!
We show that the DNA repair pathway ATM-γH2Av is repurposed in the gut during infection, even without DNA breaks. Pathogens, not microbiota, trigger it via NOX to clear damaged cells and drive stem cell regeneration. www.cell.com/cell-reports...

19.09.2025 12:47 — 👍 9    🔁 5    💬 0    📌 0

A within-host infection model to explore tolerance and resistance A mathematical model of pathogen within-host dynamics and experimental validations elucidates the interplay between immune response, damage and pathogen proliferation, highlighting the limitations of ...

It is difficult to interpret single #pathogen burden during #infection. It is hard to untangle default in resistance and tolerance to explain #susceptibility. We help making sense of with-host dynamics and give tools to study infection, especially in #Drosophila.
elifesciences.org/articles/104...

06.06.2025 13:37 — 👍 8    🔁 3    💬 1    📌 0

In preprints: a new preprint curation initiative from Development

In preprints: are microbes the architects of animal bodies?

Alessandro Bonfini, Peter Nagy and @nicobuchon.bsky.social @cornellentomology.bsky.social‬ discuss a recent #preprint from Jinru He, Thomas Bosch and colleagues:
journals.biologists.com/dev/article/...

19.05.2025 08:51 — 👍 3    🔁 4    💬 0    📌 0