Sager Gosai

MLS doing Haaland’s celebration on the ground with Gabriel next to him shocked, but poorly drawn.

Humbled

02.02.2025 18:27 — 👍 1287    🔁 222    💬 19    📌 9

Aging disrupts spatiotemporal coordination in the cycling ovary Throughout the female reproductive lifespan, the ovary completes hundreds of cycles of follicle development, ovulation, and tissue regeneration[1][1]–[3][2]. These processes rely on the precise coordi...

Exited to see this preprint led by Tammy Lan in the Sabeti Lab using spatial transcriptomics to study the impacts of aging on the cycling ovaries. www.biorxiv.org/content/10.1...

22.12.2024 04:03 — 👍 0    🔁 0    💬 0    📌 0

🧬 Genomic DNNs can be trained to learn a lot of different aspects of gene regulation, but they're not perfect and we don't know which predictions are reliable and which ones aren't.

We introduce DEGU: Uncertainty-aware Genomic Deep Learning with Knowledge Distillation. 1/n

16.11.2024 16:14 — 👍 34    🔁 9    💬 1    📌 1

Comprehensive baseline ctDNA characterization in two biomarker-selected Phase 1/2 studies using genomic and methylation profiling The development of DNA damage response (DDR)-directed therapies is a major area of clinical investigation, yet to date Poly (ADP-ribose) polymerase (PARP) inhibitors remain the only approved therapy i...

Pleased to share our latest work on genomic- and methylation-based #ctDNA analysis of baseline samples from patients with #DDR and #HRD tumors. New insights into tumor fraction estimation, HRD signatures, and reversion alterations including novel reversions in #ATM

www.medrxiv.org/content/10.1...

19.11.2024 14:56 — 👍 1    🔁 1    💬 0    📌 0

Biology of Genomes Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.

Biology of Genomes 2025 is coming up:
- meeting dates: May 6 - 10, 2025
- abstract deadline: Feb 14, 2025
We hope to see you there for another great meeting with a fantastic speaker lineup!

meetings.cshl.edu/meetings.asp...

03.12.2024 19:21 — 👍 67    🔁 34    💬 1    📌 2

It was wonderful working on this with a team of amazing collaborators across the Sabeti (Broad), @tewhey.bsky.social (JAX), Reilly (Yale), and @maryteenajoy.bsky.social (JAX) labs.

03.12.2024 21:13 — 👍 1    🔁 0    💬 0    📌 0

Machine-guided design of cell-type-targeting cis-regulatory elements - Nature A generalizable framework to prospectively engineer cis-regulatory elements from massively parallel reporter assay models can be used to write fit-for-purpose regulatory code.

Kicking off this account by sharing our paper “Machine-guided design of cell-type-targeting cis-regulatory elements” published just over a month ago www.nature.com/articles/s41... #genomics #syntheticbiology #AI

03.12.2024 21:13 — 👍 8    🔁 2    💬 1    📌 2