NIH Pragmatic Trials Collaboratory

📣 In this week's PCT Grand Rounds, Leslie Crofford of @vanderbilt.edu, Dana Dailey of University of Iowa, and @ksluka0101.bsky.social of University of Iowa will present results from FM-TIPs, an NIH Collaboratory Trial. Join us!

🔗 duke.is/pctnews2025123

December 2, 2025: Community Engagement Strategies Boost Rural Enrollment in FM-TIPS Fibromyalgia Trial - Rethinking Clinical Trials New findings from FM-TIPS show that targeted community engagement methods are highly effective in increasing recruitment and enrollment, particularly among rural participants who are typically underre...

A targeted community engagement strategy in the FM-TIPS #pragmatictrial was highly effective in increasing recruitment and enrollment, particularly among rural participants who are typically underrepresented in clinical research. #nihHEALinitiative

Learn more ➡️ duke.is/pctnews20251...

November 26, 2025: Goals-of-Care Conversations Affect Emergency Department Care in PRIM-ER Substudy - Rethinking Clinical Trials In a single-site substudy of the PRIM-ER trial, an intervention to initiate palliative care in the emergency department did not increase the proportion of patients having goals-of-care conversations. ...

In a recently published substudy from PRIM-ER, three-quarters of critically ill patients who had a goals-of-care conversation in the emergency department saw a change in code status, their care plan, hospice, or updated advance care planning documents.

➡️ duke.is/pctnews20251...

November 25, 2025: Materials Now Available From NIH-Hosted Workshop, ‘Digging Into Dilemmas of Pragmatic Clinical Trials’ - Rethinking Clinical Trials Materials and videocast recordings are now available from the NIH Pragmatic Trials Collaboratory’s recent workshop, “Digging Into Dilemmas of Pragmatic Clinical Trials.“ The 2-day workshop, hosted by ...

Materials are now available from our NIH-hosted workshop, "Digging Into Dilemmas of #PragmaticTrials." Access slides and videos for all sessions, including a keynote by David Zaas, president of Atrium Health Wake Forest Baptist and professor at @wakeforest.bsky.social.

➡️ duke.is/pctnews20251...

A graphic showing the investigators of the AIM-CP, APA-SM, ARBOR-Telehealth, BeatPainU Utah, LungSMART, and RAMP trials

Today on National Rural Health Day, learn about our innovative pragmatic trials embedded in healthcare systems serving rural and remote populations:

• AIM-CP
• APA-SM
• ARBOR-Telehealth
• BeatPain Utah
• LungSMART
• RAMP

rethinkingclinicaltrials.org/demonstratio...

#PowerOfRural #PragmaticTrials

Two new studies from the NOHARM trial explored the perspectives of patients and nurses on the implementation of a perioperative nonpharmacologic pain care education program. #nihHEALinitiative

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📣 In this week's PCT Grand Rounds, Laura Galuchie of Merck and Zak Smith of the Tufts Center for the Study of Drug Development will share insights informing strategies for optimizing clinical trial data collection. Join us!

🔗 duke.is/pctnews20251...

REGISTER TODAY — Dissemination and Implementation in Embedded Pragmatic Trials: Science-Powered Strategies to Sustain and Spread Effective Interventions — A workshop at the 18th Annual Conference on the Science of Dissemination and Implementation in Health — National Harbor, Maryland — December 14, 2025

Join experienced investigators from the NIH Pragmatic Trials Collaboratory to learn essentials of dissemination and implementation in #pragmatictrials in our full-day workshop at the @academyhealth.bsky.social 18th Annual D&I Conference. #DIScience25 #impsi

Register today! duke.is/pctnews20251...

Headshot of lead author Vanessa Miller with a screenshot of the article

In a new analysis from the OPTIMUM trial, researchers studied the prevalence and co-occurrence of chronic overlapping #pain conditions among patients with chronic #LowBackPain.

Learn more ➡️ duke.is/pctnews20251...

November 17, 2025: New Learning Module Shares Experience in Turning Routine Care Into Real-World Data Using Electronic Health Records - Rethinking Clinical Trials The NIH Pragmatic Trials Collaboratory launched a new learning module video, Lessons Learned From Implementing a Pragmatic Trial Using EHR and Other Real-World Data. The video explores opportunities f...

🎥 Check out our new learning module on using real-world data from routine clinical care in pragmatic trials, including patient selection, intervention delivery, and outcome ascertainment.

Learn more ➡️ duke.is/pctnews20251...

#DIScience25 is happening next month near DC this December 14-17! Check out all the conference has to offer, including workshops and networking events, by exploring the online agenda: buff.ly/QhlpoGp

📣 In this week's PCT Grand Rounds, Mark Siedner of @harvardmed.bsky.social will discuss IMPACT-BP, a community-based intervention for sustainable blood pressure control. Join us!

🔗 duke.is/pctgr20251114

We're thrilled to welcome 2 projects to our portfolio of innovative pragmatic trials: CARNATION and EquiP PC. Both are supported by NINDS through the #nihHEALinitiative to improve pain management and address the national opioid crisis.

Learn more ➡️ duke.is/pctnews20251...

November 6, 2025: Enrollment Begins for APA-SM and iPATH Trials - Rethinking Clinical Trials Two of the newest NIH Collaboratory Trials have begun enrollment. Congratulations to the study teams from APA-SM and iPATH for reaching this important project milestone! APA-SM is enrolling patients i...

Kudos to 2 of the newest NIH Collaboratory Trials for beginning enrollment!

👂🏼 APA-SM
🏥 iPATH

Learn about these innovative #pragmatictrials embedded in healthcare systems: duke.is/pctnews20251....

📣 In this week's PCT Grand Rounds, Daniel Pach and Stefanie Lysk of Charité Berlin will discuss EMMA: a remote, decentralized trial to evaluate the effectiveness of a migraine app. Join us!

🔗 duke.is/pctgr20251107

REGISTER TODAY — Dissemination and Implementation in Embedded Pragmatic Trials: Science-Powered Strategies to Sustain and Spread Effective Interventions — A workshop at the 18th Annual Conference on the Science of Dissemination and Implementation in Health — National Harbor, Maryland — December 14, 2025

Join experienced investigators from the NIH Pragmatic Trials Collaboratory to learn essentials of dissemination and implementation in #pragmatictrials in our full-day workshop at the @academyhealth.bsky.social 18th Annual D&I Conference. #DIScience25 #impsi

Register today! duke.is/pctnews20251...

November 3, 2025: IMPACT Collaboratory Seeks Letters of Intent for Demonstration Projects Grant Program - Rethinking Clinical Trials The NIA IMPACT Collaboratory announced a request for applications for its 2025 Demonstration Projects Grants Program. The program will fund up to 2 Demonstration Projects, each providing up to $800,00...

The IMPACT Collaboratory has announced a request for applications for its 2025 Demonstration Projects program. The awards will support full-scale #pragmatictrials of nonpharmacological interventions for people living with #dementia and their care partners.

Learn more ➡️ duke.is/pctnews20251...

A study snapshot and ethics updates are now available for APA-SM, an NIH Collaboratory Trial. This #pragmatictrial is testing an auricular point acupressure intervention for self-management of chronic pain in rural communities in South Carolina and Texas. duke.is/pctnews20251...

The Health Care Systems Research Network (HCSRN) is accepting abstract and panel submissions for its 2026 conference until December 8. The meeting will be held in Dallas from April 21 to 23 and will feature a keynote by Eduardo Sanchez of @americanheart.bsky.social.

🔗 duke.is/pctnews20251...

📣 In this week's Rethinking Clinical Trials Grand Rounds, Renato Lopes of @dukemedschool.bsky.social and @dcrinews.bsky.social will discuss insights from the PARACHUTE-HF trial and approaches to studying neglected diseases. Join us!

🔗 duke.is/pctnews20251...

🌎 Our vision: Transform #clinicalresearch by integrating high-quality research into routine patient care through the design and conduct of innovative #pragmatictrials to establish best practices and disseminate knowledge.

🥅 Our goal: Strengthen the national capacity to implement cost-effective, large-scale research studies that engage healthcare delivery organizations, communities, and patients as partners.

📜 Our history: Initiated in 2012 with support from the NIH Common Fund, our program has since transitioned to sustained funding from multiple NIH Institutes and Centers and the #nihHEALInitiative.

A graphic showing an overview of of the NIH Collaboratory program: Supports 37 large-scale, high-impact ePCTs; 16 NIH Institutes and Centers; >1400 clinical sites; >1.2 million patients; 49 US States and Puerto Rico.

🌱 Hello, Bluesky! We are the NIH Pragmatic Trials Collaboratory. Our community of researchers is advancing the design, conduct, and dissemination of pragmatic clinical trials by integrating high-quality #pragmatictrials into routine patient care.

Learn more at rethinkingclinicaltrials.org.