Esther van Kleef

AMR researchers and professionals, please join the #GRAMproject on 29th Jan to learn more about key tools and resources, including MICROBE, GLASS, the AMR R package, and the AMR data repository! Register below.
Story: bit.ly/4pJuBAD

#IDsky #Episky #Medsky

WHO publishes update on global antibiotic resistance A new report from WHO highlights the increasing threat of antibiotic resistance, particularly in regions with limited surveillance and access to antibiotics. Timothy Jesudason reports.

Missed the launch of the latest #WHO_GLASS report? Here a brief newsdesk summary @thelancetinfdis.bsky.social highlighting the progress made in GLASS participation, and why increased investment in AMR, incl. improved access to basic microbiology, remains pressing.. www.thelancet.com/journals/lan...

#EpiSky #IDSky

I should add: many AMR/stewardship interventions don't measure microbiological outcomes such as we did. By measuring microbiological outcomes using longitudinal stool sampling, we provided rare insight into AMR transmission dynamics in rural sub-Saharan Africa #Episky #IDsky

Huge thanks to an amazing collaborative team R. Aizouk, Y. Sibidou, D. Valia, @ingelbeen.bsky.social , L. Campbell, JS. Kouanda, A. Welgo, PM Diagne, B. Riems, L. Hardy, E.Wouters, M. Meudec, M. van der Sande, H. Tinto, @bugwonk.bsky.social, and the wider CABU-EICO study team!

Effect of a community-based behavioural intervention bundle to improve antibiotic use and patient management in Burkina Faso and DR Congo: a cluster randomized controlled trial Background Limited AMR awareness, limited diagnostic capacity, and frequent self-medication contribute to incorrect antibiotic use in LMIC. We evaluated a community-based intervention to improve antib...

This work comes jointly with lnkd.in/em3e-RAg.

The protocol, surveys and model codes can all be found here lnkd.in/e5aBTrSX.

So:
Low-cost, non-technology community interventions can reduce AMR. But..this also highlights that in high-burden rural AMR settings, in addition to antibiotic use, tackling environmental transmission is key!

We found:
1️⃣ High baseline AMR (ESBL-E. coli) carriage (~50%)
2️⃣ >10 times higher household-transmission than in HIC
3️⃣Antibiotic dispensing fell by >50%, with low baseline healthcare seeking and ab use
4️⃣ ~20% reduction in ESBL-E acquisition after 6 months
5️⃣Seasonal acquisition, peaking in wet season

New PREPRINT! tinyurl.com/yynzevrh Thanks to a true transdisciplinary collaboration, we developed and evaluated a low-cost community #AMR intervention set in rural Burkina Faso and DRCongo. Combining #WHO #AWaRe–based feedback/training (medicine providers) and AMR awareness campaigns (community).

Alternative way of science communication: @worldpop-uos.bsky.social made a podcast of our recent work on modelling for pandemic decision making in @eurosurveillance.org! Click on the link below to listen 👇

@mugkraemer.bsky.social

We should find sustainable mechanisms for these infrastructures and collaborations to stay, which may include funding models that bring together public, non-profit, and private-sector partners.

More to read in the full text. Thanks to all collaborators and funders @ec.europa.eu

@chpoletto.bsky.social @sdellicour.bsky.social @mariusgilbert.bsky.social @lauradidomenico.bsky.social @eonore.bsky.social Wim V. Bortel, Elena Arsevska, Vittoria Colizza, L. Busani, Shengjie Lai, P. Lemey, S. Merler, Z. Milosavljevic, A Rizzoli, D. Simic, Andy Tatem, M. Teisseire, William Wint

Intending to move beyond our “prepare-for-the-previous-pandemic” bias, this work highlights, among other findings, how the collaborative platforms and research consortia that emerged during COVID-19 laid the groundwork for new data and modelling ecosystems.

However, systematic, quantitative analyses remain rare; for COVID-19 but also for previous PH threats. These reflections are easy to set aside once urgency fades and fatigue sets in, especially in an academic world that rewards moving on quickly and governments driven by short political cycles.

Our main aim with this publication was to help preserve a collective memory of how data were generated, shared, and interpreted through modelling during the COVID-19 pandemic. Many opinions and reflections have been written.

Really great to see that our paper is now officially published in the latest #Eurosurveillance. As it was accepted with only minor edits, this earlier post still captures the key messages: tiny.cc/036u001.

I am open to the idea that there are people who don't have and don't want to gain the skills to engage directly with their data but every single day that I do I learn the answer to a question you'd never even think to ask unless you were personally staring into the abyss of an uncleaned dataset.

This has been a huge undertaking and a great leap forward in reporting global AMR surveillance data. For the first time, country, and regional-level data are supported my Bayesian modelling that allow for better comparison of resistance rates between countries/ regions and trends over time @who.int

Coming Monday 13 October, WHO will launch the latest Global antibiotic resistance surveillance report. Don't miss it, register here! www.who.int/news-room/ev...

Very excited for this event on the 9th July!

It's part of our #AMR short course but open to everyone as it's online. Do join in and here what the amazing Prof Dame Sally Davies has to stay on the current status of global action on #AMR! @lshtmamrcentre.bsky.social

We're recruiting a postdoc in our lab @mesurs-cnam.bsky.social (Paris) to work on epidemic modelling over healthcare networks, as part of the EU project ARCANE ! 💻🦠
Start date between 09/25-01/26, 2y contract

Interested in AMR, healthcare-related research & mathematical modelling? Find out more! ⬇️

Epidemiologist Epidemiologist for modelling AMR transmission in LMICMore than 500 staff members at the Institute of Tropical Medicine (ITM) contribute e...

Great ID modelling opportunity to aim for real impact on mitigating and monitoring AMR in sub-Saharan Africa. You'll work closely with us @ox.ac.uk, and Oxford’s Modernising Medical Microbiology group, as well as collaborators at CRUN (Burkina Faso) and KWRTP-KEMRI (Kenya). tinyurl.com/mry25kxe

Certainly! And sharing the knowledge here in England whenever I can now stroopwafels are almost as much an export product as Gouda cheese…

Global Antimicrobial Resistance and Use Surveillance System (‎GLASS)‎ report: antibiotic use data for 2022 This Global Antimicrobial Resistance and Use Surveillance System (GLASS) report describes global progress in GLASS-AMU surveillance and antibiotic use in 2022, reported by 60 countries. It supplements...

Not sure what happened but this link should work, thanks Quentin! www.who.int/publications...

The first preview was also presented at ESCMID global see tinyurl.com/4sh5v3hf. Combined these reports provide valuable new insights to enhance country-level use of GLASS data to help inform local, national, and regional AMR strategies World Health Organization #UNGA.

The GLASS report on antimicrobial resistance (AMR) will be published separately later this year. The 2025 GLASS AMR report will expand on previous editions by presenting regional- CTA-level AMR estimates and trends across 93 pathogen-antibiotic combinations from CTAs enrolled by the end of 2024.

The latest Global Antimicrobial Resistance and Use Surveillance System (GLASS) report on antimicrobial use is now out, reporting on 2022 national AMU surveillance data globally tinyurl.com/3muyp2pu @who.int .

Emphasising the relevance of such information is something I feel we should target, among others by working on direct ways (eg good dashboards) of feeding back national and local AMR/isolate data. Until then, we are limited to reporting AMR prevalence.