Carl D. Modes

TopoSPAM: Topology grounded Simulation Platform for morphogenesis and biological Active Matter We present a topology grounded, multiscale simulation platform for morphogenesis and biological active matter. Morphogenesis and biological active matter represent keystone problems in biology with ad...

🤩👍🏼💪🏼 Meet #TopoSPAM - a high-performance simulation platform for biological morphogenesis with a friendly Python interface. @tudresden.bsky.social @csbdresden.bsky.social @mpi-cbg.de. Solve both continuous and discrete active mechanics! Released today: arxiv.org/abs/2509.24905

So happy to see the cephalic furrow combo out back-to-back! This was a wonderful collaborative endeavor 🥹

The moral of the story is that building the #bridge between #evolution & #morphogenesis is hard. I still think it needs a concerted push, because, to paraphrase the classic: "Everything in biology, even the #CF, starts making sense in the light of evolution." I add, it is #stuff_that_matters (12/12)

We are all super happy and proud to see our work on the function and evolution of the #cephalic #furrow published in @nature.com. Let me say a few things about the background and history of this work on the #Evolution_of_Morphogenesis (1/12)

Mechanical forces drive evolutionary change A small tissue fold present in fruit fly embryos buffers mechanical stresses and may have evolved in response to mechanical forces.

Dresden researchers @paveltomancak.bsky.social @bruvellu.bsky.social, Carl Modes, @cuencam15.bsky.social ‬ & colleagues published in @nature.com that a tissue fold in fruit fly embryos buffers mechanical stresses & may have evolved in response to mechanical forces. www.mpi-cbg.de/news-outreac...

Fantastic interaction with @carldmodes.bsky.social
and @liormoneta.bsky.social , who did all the modelling. It was great to work in such an interchangeable setting between biology and physics, to lear about #ShapeProgramming and shed a little more light on how organs gain their 3D shape.

The Optic cup is actively shape programmed by independently patterned apical forces During morphogenesis, initially flat tissues often must transition into complex 3D shapes, reminiscent of shape-programmable systems in physics and engineering. One key question in developmental biolo...

I am thrilled to share the main result of our work at @nordenlab.bsky.social with @liormoneta.bsky.social and @carldmodes.bsky.social . We bridged DevBiology + theoretical physics to understand how the eye becomes round #morphogenesis #devbio #biophysics #zebrafish www.biorxiv.org/content/10.1...

Thanks André! And hello Bluesky world!

Thanks for the arm twist, @nordenlab.bsky.social !