#QuPath + Imglib2 and #BDV ❤️

Promising start!

(Mainly Léo and Pete's work github.com/qupath/qupat... + a small addition)

Jonathan's "Opus Magnum" is finally out. Fundamental discovery. Congratulations!

We present multi-immersion Oblique Plane microscope (miOPM), a light-sheet platform that can be adapted to a wide range of applications, from sensitive live cell imaging to imaging organs and cleared tissues.
www.biorxiv.org/content/10.1...

Screenshot from Neuroscience Bulletin journal webpage with text: Sandman is a Sleep Switch in Drosophila Research Highlight | Published: 13 September 2016 Volume 32, pages 503-504, (2016) Cite this article

drosophila gene names never fail to crack me up

Latest from ours: www.cell.com/cell-reports...

This is two stories in one: a case study/cautionary tale on developing genetic tools in new organisms, and the first hint at a gene regulatory network for choanoflagellate multicellular development (which turn out to involve a Hippo/YAP/ECM loop!) A 🧵

My entry for today’s #FluorescenceFriday: a pupal #Drosophila testis with muscles expressing
🔵 lifeact &
🔴 RFP-nls

Honored & grateful to receive an honorable mention at @healthcare.nikon.com Nikon Small World 🌍🔬✨

🔗 www.nikonsmallworld.com/galleries/20...

#NikonSmallWorld #Microscopy #ScienceArt

164887 Professor or Associate Professor and Research Group Leader with special focus on molecular me - Copenhagen, Hovedstaden (DK) job with The Biotech Research and Innovation Centre (BRIC), Universi... BRIC wishes to recruit a strongly motivated scientist at Associate Professor or Professor level for an independent research group leader position. ...

We have an open group leader position in diabetes 1 research.
Please circulate!

www.nature.com/naturecareer....

good ole Louisville KY
@slewzeus.bsky.social @burgesslab.bsky.social @benoitbruneau.bsky.social @chrmosimann.bsky.social @lucksmith.bsky.social @docdellaire.bsky.social @fish4walking.bsky.social @daphsci.bsky.social @mads100tist.bsky.social

Yesterday, Radovan Fiala received the Silver Medal of Masaryk University for his outstanding contribution to NMR spectroscopy and structural biology 🔬 Congratulations! 👏
#CEITECScience
@masarykuniversity.bsky.social
📷 Martin Indruch

Figure 1: Fluorophore intensity in the Drosophila blastoderm (n.c. 14). Comparison of (A) green and (B) red fluorescence intensity using the same intensity scaling in n.c. 14. The fluorescence signal did not saturate. Shown are single imaging planes. Normalised histograms of fluorescence intensity for green (C) and red (D) fluorophores averaged across at least n=3 embryos per line. Scale bars = 20 μm

Identification of optimal fluorophores for use in the Drosophila embryo by Timothy E Saunders and team: www.biorxiv.org/content/10.1...

Two years today! Very grateful 🙏 @mpi-cbg.de @csbdresden.bsky.social @math-mpicbg.bsky.social

New Perspectives on the Hidden World of Proteins  Schering Young Investigator Award 2025 goes to Agnes Toth-Petroczy

Schering Young Investigator Award 2025 by the Schering Stiftung for Agnes Toth-Petroczy @tothpetroczylab.bsky.social @mpi-cbg.de @csbdresden.bsky.social. She receives the award for her work on the evolution, diversity, and function of proteins. Congratulations! 🎉 www.mpi-cbg.de/news-outreac...

Some things never change. 30 years! #ISG

Traveling in #Germany. The open hostility of a Sachsen lady at the Bahnhof store towards an immigrant customer who just wanted to buy cigarettes. He was on a job. How are they suppose to belong? Broken society. But then, super nice conversation with a Kosovo Albanian in a Heidelberg taxi. 🤷‍♂️

Sex or growth? Life must continually balance these strategies. We forced yeast to choose and captured the trade-off in real time. Evolution rewired existing regulators and fixed them through genetic assimilation, creating specialists for sex at the cost of growth. https://www.biorxiv.org/cgi/content/short/2025.09.26.678705v1 Thrilled to finally share this seven-year story—a journey that began during my postdoc in Sophie’s lab and continued for four more years as I built my own lab in Shenzhen.

Sex or growth? Life must continually balance these strategies. We forced yeast to choose and captured the trade-off in real time. Evolution rewired existing regulators and fixed them through genetic assimilation, creating specialists for sex at the cost of growth.
www.biorxiv.org/cgi/content/...

Fully agree, it is feedbacks all the way.

Our latest preprint! Into morphogenesis, Yap, ECM, signaling, vertex models, feedbacks/robustness? There is something here for everyone. We discovered a positive feedback loop that extends inner ear canals, and a built-in mechanism that shuts it down when morphogenesis is done. tinyurl.com/464wsjhd

Looking for the inner fish?

Do you mean to redirect it all to a centralized pre-print server, such as bioRxiv? Besides costing A LOT of money, this smells of a monopoly, which is never good.

In this intriguing paper published from the lab of @amartinezarias.bsky.social , they looked at the effects of size on morphology, tissue composition, and gene expression of gastruloid development. They found that AP elongation dynamics is size-dependent! Check it out here:
doi.org/10.1016/j.cd...

I cannot claim to understand the economics of it, but I think the hefty price tag on OA publication comes from having dedicated people perform these kinds of checks. (besides peer review and, well, profit). I don't see how bioRxiv can do anything near this and remain "free".

Dear JEDIs,
as we are self-organizing using the #EDRC as a nucleator we decided it is time for a JEDI database to boost our network! If you identify as a JEDI, please contact us here or send a mail to katja.rust@uni-marburg.de to be added to our database.
#Drosophila
@fly-eds.bsky.social

Back to work on #bigvolumebrowser, I've added the import of point clouds that change over time. The test data generation was a pleasant detour into the world of attractors (Thomas' cyclically symmetric is shown).

I am out of my depth on PRC, but I am glad to see that this nucleates a discussion. Not enough of that on BlueSky.

By videos, I mean supplementary videos that support the conclusions of the work. You CAN upload them to bioRxiv, but AFAIK you don't HAVE TO. For a worldwide pre-print mega-repository, even the storage capacity may become an issue.

Should be is not good enough. There will always be a perfectly defensible reason to post the main text without the supplements (which are not ready for prime time). It needs the editorial staff to let you know that we cannot proceed unless you include the file you are referring to in the main text.

I'm not sure I interpret you correctly, but if bioRxiv were to go down that road, i.e., requiring more and more precision at the pre-print submission stage, wouldn't the costs skyrocket?

Playing devils advocate, before we throw out the OA movement of the past decades out of the window.

If we are to read exclusively pre-prints in the future, can we at least require to inline Figures with text? The pre-print format is all geared towards peer review, not the convenient presentation of the science.

I can see that this potentially shifts the emphasis to pre-prints. But, with pre-print servers everything is voluntary. There is often no supplements, no videos, no source data, no one mandates deposition to repositories (or?). This is what journals do. Now all that will be behind the paywall.