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@paveltomancak.bsky.social

1,201 Followers  |  374 Following  |  460 Posts  |  Joined: 02.03.2025  |  1.9183

Latest posts by paveltomancak.bsky.social on Bluesky

A whiteboard covered over with many layers of black and red pan scribbles, including some mathematical and Greek letters

A whiteboard covered over with many layers of black and red pan scribbles, including some mathematical and Greek letters

Latest in “The Unerased Whiteboards of UCL” series… now this is a classic example of insufficient erasure leading to multiple sedimentary layers of thought – my personal favourite sort of whiteboard residue.

Also resembles something you might see in the Tate Modern.

05.12.2025 21:00 — 👍 9    🔁 1    💬 1    📌 0
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Molecular basis for de novo thymus regeneration in a vertebrate, the axolotl The molecular, cellular, and functional restoration of the axolotl thymus after de novo regeneration is described.

Can't believe my postdoc paper is finally out. Christmas came early this year, holy moly 🎄

Molecular basis for de novo thymus regeneration in a vertebrate, the axolotl | Science Immunology www.science.org/doi/10.1126/...

05.12.2025 21:17 — 👍 30    🔁 12    💬 4    📌 0
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Come join us in beautiful Roscoff for this Conference Jacques Monod on Developmental regulation: from molecular to ecological niches
May 18-22, 2026 Roscoff, France
Abstract deadline: January 31, 2026
Apply here: cjm.sb-roscoff.fr/en

03.12.2025 08:00 — 👍 27    🔁 23    💬 0    📌 0
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Happy to share the first paper from my journey at @psich.bsky.social towards X-ray connectomics, now out in @natmethods.nature.com: www.nature.com/articles/s41...

27.11.2025 10:21 — 👍 38    🔁 15    💬 1    📌 0

Hmm, I must have the same thing….

03.12.2025 08:53 — 👍 1    🔁 0    💬 0    📌 0

Congratulations Berta!

03.12.2025 08:51 — 👍 1    🔁 0    💬 1    📌 0
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wow... crawling motility in Asgard #archaea!! www.biorxiv.org/content/10.1...

look at these crazy moves!! Let's face it, what these cells want for Christmas is #cilia... the best type of motility appendage...

02.12.2025 22:30 — 👍 32    🔁 9    💬 3    📌 0
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Toward better 2D - 3D registration in BigWarp BigWarp has so far focused on 2D-2D or 3D-3D registration, and not on 2D-3D registration. After a conversation with @Christian_Tischer , we thought some simple UI changes could make the support for 2...

Do you have 2D-to-3D image registration challenges? Let me know about them here
forum.image.sc/t/toward-bet...

29.11.2025 18:03 — 👍 20    🔁 11    💬 0    📌 0
Title of a Substack essay: "Why I'm Betting Against the AGI Hype" by Mike Brock.
Shows a picture of a little girl holding the hand of a robot.

Title of a Substack essay: "Why I'm Betting Against the AGI Hype" by Mike Brock. Shows a picture of a little girl holding the hand of a robot.

"The real danger isn’t that machines will become intelligent—it’s that we’ll mistake impressive computation for understanding and surrender our judgment to those who control the servers." Mike Brock […]

[Original post on spore.social]

29.11.2025 13:57 — 👍 8    🔁 2    💬 1    📌 0

One of our founding directors Anthony Hyman @hymanlab.bsky.social will become @embl.org Director General: www.mpi-cbg.de/news-outreac...

27.11.2025 13:20 — 👍 63    🔁 14    💬 1    📌 0

Huge news from EMBL. Congratulations Tony. It marks a big change for @mpi-cbg.de and for @embl.org alike. Good luck!

27.11.2025 13:10 — 👍 21    🔁 2    💬 1    📌 0

At the #VADERs in Jan?

26.11.2025 17:47 — 👍 1    🔁 0    💬 1    📌 0
Me holding my book “Dinosaur Feeding Biology”.

Me holding my book “Dinosaur Feeding Biology”.

Ready to eat your dinosaur (turkey) tomorrow? Learn all about how to eat LIKE a dinosaur! 🦖 🦃

26.11.2025 17:19 — 👍 10    🔁 3    💬 0    📌 0

Congratulations Carlos and the rest of the team.

26.11.2025 17:38 — 👍 1    🔁 0    💬 1    📌 0
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Evolution of taste processing shifts dietary preference - Nature Calcium imaging of taste neurons and the ventral brain provides insight into evolutionary divergence of food choice in Drosophila species, supporting a role of sensorimotor processing in addition to p...

Thrilled to share our new paper!
With @tomtom-auer.bsky.social team, we asked how #evolution reshapes what animals #eat to match their ecological niches. Using pan-neuronal Ca2+ imaging, we show that the changes are in how the brain processes #taste.
Link @nature.com: www.nature.com/articles/s41...

26.11.2025 16:33 — 👍 170    🔁 60    💬 9    📌 3
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(1/3) Imagine reconstructing a history over a billion years in the making.

New research from EMBL and @Stanford shows how centromeres retain their function despite their rapid rate of change, and the evolutionary constraints that govern this process.

www.nature.com/articles/s41...

26.11.2025 16:06 — 👍 13    🔁 9    💬 1    📌 0
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An archaeal genetic code with all TAG codons as pyrrolysine Multiple genetic codes developed during the evolution of eukaryotes and bacteria, yet no alternative genetic code is known for archaea. We used proteomics to confirm our prediction that certain archae...

Some archaea—an ancient group of microorganisms—have an entirely novel genetic code, according to a new study in Science.

The findings expand our understanding of how alternative genetic codes evolve and hint at new molecular tools for biotechnology applications. https://scim.ag/4omApQ7

25.11.2025 20:24 — 👍 76    🔁 24    💬 1    📌 6
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Greetings from Prague!
The HFSP Masterclass is in full swing 🇨🇿 — welcoming early career researchers from Central Europe to explore HFSP funding, frontier science, and international collaboration.
#HFSPmasterclass #HFSP #GlobalScience #ScienceWithoutBorders
🧪 #sts

26.11.2025 08:04 — 👍 5    🔁 2    💬 0    📌 1
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📢 Paper alert 📢

Chirality is known to be important for the movement of microorganisms and active matter. In our new paper out today in @natphys.nature.com, we show that chirality is used by malaria parasites to control their motion patterns:

doi.org/10.1038/s415...

Here comes a 🧵 ... (1/9)

24.11.2025 17:50 — 👍 76    🔁 31    💬 1    📌 2
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Motivational video for #MigrationMovieMonday. A persistent 4T1 breast cancer cell squeezing itself through a tight constriction despite undergoing repetitive nuclear envelope rupture. Credit: Kristen Nedza @weillinstitute.bsky.social

25.11.2025 01:36 — 👍 44    🔁 12    💬 1    📌 2
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Revised refereed preprint:
www.biorxiv.org/content/10.1...
Revision work lead by @longweibai.bsky.social

Our work reveals how the #microbiota helps buffer #malnutrition: L. plantarum sustains intestinal activity of the steroid hormone ecdysone, expanding the midgut and supporting systemic growth.

23.11.2025 06:19 — 👍 25    🔁 6    💬 1    📌 0
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Fluorescent protein and peptide tags alter condensate formation and dynamics in vivo and in vitro | EMBO reports imageimageProtein and peptide tags can profoundly alter condensation in a tag- and protein-specific manner, both in cells and in vitro, highlighting the need for careful validation in condensate studi...

This is important for 🧪🔬
www.embopress.org/doi/full/10....

22.11.2025 07:16 — 👍 11    🔁 5    💬 0    📌 1

Congratulations 🎉

22.11.2025 14:56 — 👍 2    🔁 0    💬 1    📌 0
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Dynamic cellular interfaces reloaded!🎉 Happy and excited to receive extended funding @sfb1348.bsky.social @uni-muenster.de @mpi-muenster.bsky.social and to push our collaborative science forward in the next 4 years! Big thanks @dfg.de, reviewers, and everyone else involved for the continued support!

21.11.2025 11:37 — 👍 42    🔁 9    💬 5    📌 3

#stuffthatmatters 👇

21.11.2025 10:02 — 👍 6    🔁 1    💬 0    📌 0
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Intracellular competition shapes plasmid population dynamics From populations of multicellular organisms to selfish genetic elements, conflicts between levels of biological organization are central to evolution. Plasmids are extrachromosomal, self-replicating g...

Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/
www.science.org/doi/10.1126/...

20.11.2025 21:42 — 👍 430    🔁 200    💬 11    📌 18
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Adversarial Poetry as a Universal Single-Turn Jailbreak Mechanism in Large Language Models We present evidence that adversarial poetry functions as a universal single-turn jailbreak technique for Large Language Models (LLMs). Across 25 frontier proprietary and open-weight models, curated po...

absolutely LOVE this preprint on tricking LLMs using poetry:
arxiv.org/abs/2511.15304
Like magic spells, you need to use the correct pentameter or the demon won't listen

21.11.2025 02:07 — 👍 17    🔁 7    💬 0    📌 3
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We just released a new major version of TrackMate (v8), the cell and organelle tracking plugin of Fiji.

It ships many new features, detailed below, but that are articulated around the following:

20.11.2025 11:42 — 👍 175    🔁 74    💬 4    📌 6
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Cellular structure self-organizes through an interplay between internal mechanisms and external cues. The single-celled suctorian P. collini builds a trap structure to capture large prey using microtubule feeding tentacles, creating feedback between cell morphology and prey availability.

18.11.2025 16:15 — 👍 87    🔁 22    💬 2    📌 14
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Q & A Interview with Cassandra Extavour, who studies the evolution of the genetic mechanisms employed during early animal embryogenesis to specify cell fate, development, and differentiation at Harvard Univ...

Check out our latest issue where we interview Cassandra Extavour, who studies the evolution of the genetic mechanisms employed during early animal embryogenesis to specify cell fate, development, and differentiation at Harvard University. www.cell.com/current-biol...

20.11.2025 10:34 — 👍 46    🔁 22    💬 0    📌 2

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