Predicting when symptoms of Alzheimer's disease will occur with a single elevated p-tau217 blood test and a person's age, even 20+ years in advance
@naturemedicine.bsky.social
nature.com/articles/s41...
Predicting when symptoms of Alzheimer's disease will occur with a single elevated p-tau217 blood test and a person's age, even 20+ years in advance
@naturemedicine.bsky.social
nature.com/articles/s41...
Subtle differences in repeat motifs can cause drastic diff in disease onset: using @pacbio.bsky.social PureTarget amp-free identifies non-canonical repeats and its ratio assoc. with disease onset for Spinocerebellar ataxia type 10 (SCA10)
www.neurology.org/doi/full/10....
PangyPlot: a new #bioinformatics tools for visualizing pangenomes that supports linear coordinates and large graphs. Applied to @pacbio.bsky.social HiFi genomes to visualize two cystic fibrosis-relevant region not possible to resolve with short read genomes. www.biorxiv.org/content/10.1...
10.11.2025 18:33 — 👍 6 🔁 1 💬 0 📌 0
How does @pacbio.bsky.social long-read RNA-Seq help explain response difference through RNA splicing regulation in immunotherapy? Check out the Dec webinar with @olgaanczukow.bsky.social and Ryan Englander and I! www.the-scientist.com/long-read-rn...
06.11.2025 21:35 — 👍 4 🔁 1 💬 0 📌 0
New @pacbio.bsky.social #bioinformatics spotlight video is up! SQANTI-QC: a multi-sample long-read RNA-Seq QC tool! Demo included. Check it out and give it a try! www.youtube.com/watch?v=83XL...
05.11.2025 21:33 — 👍 3 🔁 0 💬 0 📌 0
A new multi-center study from the EMEA HiFi Solves Consortium shows the clinical research potential of HiFi. Combined with our latest informatics pipeline, HiFi identified 100% of clinically relevant variants across 11 complex regions, including those short reads missed.
👉 bit.ly/4oqMWCY
Wonder how @pacbio.bsky.social long read sequencing is transforming how clinical and translational labs approach genomics? Hear from panelists from Myriad Genetics, GeneDx, Karolina and Radboudumc discuss rare disease testing, carrier screening, and more! programs.pacb.com/l/1652/2025-...
27.10.2025 23:58 — 👍 3 🔁 0 💬 0 📌 0
Want a rare look inside @pacbio.bsky.social facility and hear how customers use HiFi for HLA typing and PGx? We made a 6-min documentary this summer. Check it out! www.youtube.com/watch?si=nXb...
23.10.2025 16:15 — 👍 2 🔁 1 💬 0 📌 0
Just published an interactive article about a magical algorithm known as the Burrows-Wheeler Transform, which powers sequence alignment tools like bowtie and bwa: sandbox.bio/concepts/bwt
It's also notoriously unintuitive so I'm hoping this article helps you build that intuition.
How does @pacbio.bsky.social long-read sequencing and AI interact to assess AAV genome integrity? Find out at this Catalent webinar on 10/29! event.on24.com/wcc/r/509468...
09.10.2025 22:24 — 👍 0 🔁 0 💬 1 📌 0
Why it's good to incorporate @pacbio.bsky.social long-read bacterial WGS into routine hospital surveillance for AMR tracking: 540 multidrug-resistant Gram-negative bacterial genomes revealed extensive and previously missed plasmid-mediated transmission events. journals.asm.org/doi/10.1128/...
06.10.2025 18:12 — 👍 2 🔁 1 💬 0 📌 0
How do you prep 1,000 @pacbio.bsky.social Kinnex bulk RNA-Seq samples consistently? With @sptlabtech.bsky.social Firefly for automation! Join this @selectscience.bsky.social webinar next week to hear about it! www.selectscience.net/webinar/auto...
15.09.2025 15:53 — 👍 2 🔁 0 💬 0 📌 1
The human #microbiome holds enormous potential, but only if we can see it clearly.
Join this webinar to learn how #PacBio HiFi sequencing delivers accurate, high-resolution insights with 16S rRNA sequencing and shotgun metagenomics.
Secure your spot: bit.ly/4mYmK1G
If DNA sequencing technologies had dating profiles 😜🧪
20.08.2025 20:27 — 👍 1 🔁 0 💬 0 📌 0Learn from about @pacbio.bsky.social HiFi and then have a chance to WIN some!
19.08.2025 19:30 — 👍 4 🔁 0 💬 0 📌 0
Rarely do I get this excited about a @pacbio.bsky.social Iso-Seq study! 🧠 Come hear how the Tripathy lab used long-read multiomics to study neuron development—finding new isoforms suggesting some non-coding ASD variants may disrupt splicing & protein function. programs.pacb.com/l/1652/2025-...
14.08.2025 17:42 — 👍 0 🔁 0 💬 0 📌 0
AI saves elephants from being hit by trains in India. You can use AI for good! 🐘💫 timesofindia.indiatimes.com/india/ai-sav...
13.08.2025 19:13 — 👍 2 🔁 0 💬 0 📌 0
Just released @pacbio.bsky.social Kinnex-10x GEM-X single cell data for both Revio and Vega! Go check out the updated app note and dataset URL!
App note: www.pacb.com/wp-content/u...
Dataset: downloads.pacbcloud.com/public/datas...
Project JAGUAR, led by the @sangerinstitute.bsky.social and Latin American researchers, aims to build the first immune cell atlas representing Latin American populations—addressing equity and ancestry in genomics.
#PacBio is proud to support with #HiFiSequencing.
Read the blog: bit.ly/4l63Kwz
#PacBio is contributing Iso-Seq data to the 1000 Genomes Long Read Sequencing Project using #Kinnex kits and the #Revio system.
This data from 1,000 globally diverse samples will help advance transcript-level insights across populations.
Press release here: bit.ly/4mdzHEe
A once-in-a-decade bloom of Chanel the corpse flower (Amorphophallus Titanum) at the San Francisco Conservatory of Flowers and I caught the very tail end of its 48 hour blooming span! 🌸🌸🌷🌷
10.07.2025 17:36 — 👍 2 🔁 0 💬 0 📌 0Learn from the best @pacbio.bsky.social users on their tips and tricks! (fun fact: I interviewed Lutz but I'm behind the camera so you won't see me ;>)
23.06.2025 21:36 — 👍 3 🔁 1 💬 0 📌 0
Spotlight on the gut-brain axis
A rapid expansion of new discoveries and knowledge lays the foundation for a new era in medicine
erictopol.substack.com/p/the-gut-br...
Deepest long-read RNA-Seq dataset for one single cell line, multiple time points + replicates using @pacbio.bsky.social Kinnex RNA kit! Wissel et al. show that Kinnex can be used for isoform quantitative analyses: www.biorxiv.org/content/10.1...
12.06.2025 22:15 — 👍 11 🔁 1 💬 0 📌 1
Really loving this live demo of our @pacbio.bsky.social Vega benchtop sequencer by the one-and-only Sterling Maurer. Vega is so simple...probably I can do it (but I shouldn't XD)
www.youtube.com/watch?v=wK90...
If you're in the San Francisco bay area and is a 10x single-cell/spatial user, @pacbio.bsky.social will be at the UCSF Gladstone 10x Symposium next week! I'll be there too! Come learn how to power up your 10x data with long reads! tinyurl.com/2mev7pj6
05.06.2025 17:53 — 👍 1 🔁 0 💬 0 📌 0
Next week! Come learn how @pacbio.bsky.social HiFi enables IGH genotyping and near-full-length TCR/BCR sequencing for immunotherapy research!
programs.pacb.com/l/1652/2025-...
So fantastic to see an all women panel at #PacBioPRISM today moderated by @magdoll.bsky.social. #HiFi #longreads @pacbio.bsky.social
16.05.2025 14:09 — 👍 7 🔁 3 💬 0 📌 0@pacbio.bsky.social instrument lounge at PRISM San Francisco event today! Great talks this morning and now we’re moving into parallel workshops.
07.05.2025 18:00 — 👍 7 🔁 2 💬 0 📌 0
