Unraveling posttranscriptional regulatory networks in phage infection
Phages employ sophisticated transcriptional regulatory networks to optimize replication. Recently, Silverman et al. used RIL-seq (RNA interaction by lβ¦
Like bacteria, phages use sRNAs to regulate gene expression! Out today in @cp-trendsmicrobiol.bsky.social, @mvelascogomariz.bsky.social and I highlight a recent RIL-seq study from the @saharmelamed.bsky.social lab that looked into posttranscriptional regulation of lambda!
tinyurl.com/lambda-RIL-seq
26.02.2026 13:29 β
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Assistant/Associate/Full Professor Computational Biology
Assistant/Associate/Full Professor Computational Biology
Join us as Assistant/Associate/Full Professor Computational Biology at Institute of Biology Leiden (IBL) / @leidenscience.bsky.social / @unileiden.bsky.social
Application deadline on 15 March 2026
π
careers.universiteitleiden.nl/job/Assistan...
26.02.2026 10:52 β
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Please RT:
Looking forward to our International Symposium on "Microbial Networking - from organelles to cross-kingdom communities".
Highlight of our first funding period of our Collaborative Researc Center @mibinet.bsky.social, @dfg.de
www.sfb1535.hhu.de/mibinet
@hhu.de , @fz-juelich.de
19.02.2026 14:45 β
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Whatβs holding back clinical use of phage therapy in the UK?
Our workshop last year brought together international experts, biotech and regulators to find out
Meeting Report out now in Nature Microbiology with our take on the challenges and opportunities facing the UK phage therapy sector
14.02.2026 17:54 β
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Bacterial defense via RES-mediated NAD+ depletion is countered by phage phosphatases
Many bacterial defense systems restrict phage infection by breaking the molecule NAD+ to its constituents, adenosine diphosphate ribose (ADPR) and nicotinamide (Nam). To counter NAD+ depletion-mediated defense, phages evolved NAD+ reconstitution pathway 1 (NARP1), which uses ADPR and Nam to rebuild NAD+. Here we report a bacterial defense system called aRES, involving RES-domain proteins that degrade NAD+ into Nam and ADPR-1β³-phosphate (ADPR-1P). This molecule cannot serve as a substrate for NARP1, so that NAD+ depletion by aRES defends against phages even if they encode NARP1. We further discover that some phages evolved an extended NARP1 pathway capable of overcoming aRES defense. In these phages, the NARP1 operon also includes a specialized phosphatase, which dephosphorylates ADPR-1P to form ADPR, a substrate from which NARP1 then reconstitutes NAD+. Other phages encode inhibitors that directly bind aRES proteins and physically block their active sites. Our study describes new layers in the NAD+-centric arms race between bacteria and phages and highlights the centrality of the NAD+ pool in cellular battles between viruses and their hosts. ### Competing Interest Statement The authors have declared no competing interest. European Research Council, ERC-AdG GA 101018520 Israel Science Foundation, MAPATS grant 2720/22 Deutsche Forschungsgemeinschaft, SPP 2330, grant 464312965 Minerva Foundation with funding from the Federal German Ministry for Education and Research research grant from Magnus Konow in honor of his mother Olga Konow Rappaport Ministry of Aliyah and Immigrant Absorption, https://ror.org/05aycsg86 Clore Scholars Program
We found a new mode by which bacteria deplete NAD+ to protect from phages. And then we found how phages overcome this defense
Discovered by talented biochemist Dr Ilya Osterman, read the preprint: tinyurl.com/Narp-ap
A thread π§΅
29.01.2026 15:34 β
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We are looking for a junior group leader in RNA biology to join us in WΓΌrzburg at the @helmholtz-hiri.bsky.social !
A generous funding package, a great collaborative environment, and a beautiful city are all included :)
Deadline for application is Feb 15; more information below π
28.01.2026 09:28 β
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Our new publication in #ISMEJournal (@isme-microbes.bsky.social) describes how Bacillus and Trichoderma works together to fight against the plant pathogen Fusarium, a superb collaboration with Zhihui Xu at Nanjing Agricultural University, including the experiments by @jiyuxie.bsky.social at #IBL
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29.12.2025 10:30 β
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Molecular Biology of Archaea: Life Through the Prism of Archaea
In 1977, Woese and colleagues revealed Archaea as a distinct domain of life. Building on this insight, the discovery of Asgard archaea has strengthened the view that many hallmarks of eukaryotic cellβ¦
Are you a long-time fan of Archaea, an extremophile-phile, or are you simply curious?
Either way, we have good news.
Weβre delighted to announce the 2026 EMBO Workshop on Archaea, 6β10 July.
Sign up: meetings.embo.org/event/26-arc...
We look forward to seeing you in Cambridge, UK.
Please repost!
16.12.2025 12:00 β
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Just got word that we are a go for the Bacterial Cell Biology and Development GRS and GRC at Southern New Hampshire University!
GRS will be on June 5-6, 2027
GRC will be from June 6-11, 2027
Block off your calendars Prokaryotic Cell Biologists!
More details to come! Please repost!
12.12.2025 14:58 β
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Just realising again on my way to work: AI will never ever be able to bring the joy @eliza-coli.bsky.social images bring to me whenever I walk through my Institute's hallway. Thanks so much, Eliza!
05.12.2025 12:15 β
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Phage-induced lysis may only be the beginning of something else. Great effort by Antonio (first and corresponding author) showing the occurrence of extracellular DNA synthesis and structuring!
www.biorxiv.org/content/10.6...
04.12.2025 16:01 β
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So happy to announce our new preprint, βA geothermal amoeba sets a new upper temperature limit for eukaryotes.β We cultured a novel amoeba from Lassen Volcanic NP (CA, USA) that divides at 63Β°C (145Β°F) π₯ - a new record for euk growth!
#protistsonsky π§΅
25.11.2025 20:41 β
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Testrun underway.
25.11.2025 15:37 β
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We have wondered what a complex archaeal cell might look like ever since 2014. Itβs been a long road (and the journey is far from over), but itβs a good time to pause for breath and look. These Asgard archaeal cells are a surprise! And that is the joy of being a cell biologist.
07.11.2025 11:02 β
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An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von KΓΌgelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
07.11.2025 10:44 β
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Bacteria can sense when a virus starts shredding their genome β by detecting methylated mononucleotides.
Hereβs the story of how we discovered the Metis defense system π
www.biorxiv.org/content/10.1...
06.11.2025 04:59 β
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π’ Postdoc position: Cell Biology of Cyanobacteria
in my group, as part of the Excellence Cluster "Microbes for Climate" (M4C) in Marburg, Germany.
More information at shorturl.at/wNnDT (see Project 2)
πApply at shorturl.at/VsEDl
π
Deadline: Nov 16, 2025
Please repost. #Postdoc
02.11.2025 19:13 β
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Postdoctoral researcher in molecular ecology - Uppsala University
Postdoctoral researcher in molecular ecology, Department of Ecology and Genetics, Uppsala University
π’ We have an open position for a postdoc to join my lab. It's a great position @animecol-uu.bsky.social, fully salaried for 2.5 years with all benefits.
www.uu.se/en/about-uu/...
The project is about transmission patterns of bacteria and antimicrobial resistance (AMR) in aquatic insects. π§¬π¦ (1/3)
27.10.2025 07:43 β
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Could not agree more π
11.10.2025 19:22 β
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Microbiology and Immunology β Faculty Position (Ladder Rank) β Assistant Professor
University of California, San Francisco is hiring. Apply now!
Our Department of Microbiology & Immunology at UCSF is running a faculty search this year for a new Assistant Professor! Please see the ad below for details. Searching for a great colleague, mentor, and scientist!
aprecruit.ucsf.edu/JPF05807
25.09.2025 17:51 β
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Thanks for having us on board, Khaled!
19.09.2025 14:34 β
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ComFB, a widespread family of c-di-NMP receptor proteins | PNAS
Cyclic dimeric-GMP (c-di-GMP) is a ubiquitous bacterial second messenger that regulates
a variety of cellular processes, including motility, biofil...
And here is the published version of the work from @selimlab.bsky.social, @mygalperin.bsky.social, Dubnau labs and @thethormannden.bsky.social labs
(superb collaboration)
ComFB, a widespread family of c-di-NMP receptor proteins
www.pnas.org/doi/10.1073/...
19.09.2025 11:04 β
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Happy to share that our story on the bacterial archaellum was published today in @natmicrobiol.nature.com
www.nature.com/articles/s41...
Congrats to the authors: @sshamphavi.bsky.social @loumollat.bsky.social @mariejoest.bsky.social Najwa Taib and @sgribaldo.bsky.social
17.09.2025 17:41 β
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Willing to join us @pasteur.fr for a PhD for a project on how interactions between mobile genetic elements shape bacterial adaptation? Subject to be tailored to candidates with keen interest in evolution, genomics, computational biology, microbiology. Check www.pasteur.fr/en/education...
08.09.2025 08:56 β
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A new theme issue of #PhilTransB examines the evolutionary history of bacterial immune systems, their modes of action, and the patterns how different bacterial immune systems are distributed across different ecosystems. Read: buff.ly/Z4qdxY1
05.09.2025 16:01 β
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