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The Thormann Lab

@thethormannden.bsky.social

Roaming at the Justus Liebig University in Giessen, Germany. Interested in bacteria, cell biology, motility, phages and the various wonders of life.

997 Followers  |  1,275 Following  |  31 Posts  |  Joined: 07.11.2023
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Posts by The Thormann Lab (@thethormannden.bsky.social)

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Unraveling posttranscriptional regulatory networks in phage infection Phages employ sophisticated transcriptional regulatory networks to optimize replication. Recently, Silverman et al. used RIL-seq (RNA interaction by l…

Like bacteria, phages use sRNAs to regulate gene expression! Out today in @cp-trendsmicrobiol.bsky.social, @mvelascogomariz.bsky.social and I highlight a recent RIL-seq study from the @saharmelamed.bsky.social lab that looked into posttranscriptional regulation of lambda!

tinyurl.com/lambda-RIL-seq

26.02.2026 13:29 β€” πŸ‘ 26    πŸ” 14    πŸ’¬ 1    πŸ“Œ 2
Assistant/Associate/Full Professor Computational Biology Assistant/Associate/Full Professor Computational Biology

Join us as Assistant/Associate/Full Professor Computational Biology at Institute of Biology Leiden (IBL) / @leidenscience.bsky.social / @unileiden.bsky.social

Application deadline on 15 March 2026
πŸ‘‡
careers.universiteitleiden.nl/job/Assistan...

26.02.2026 10:52 β€” πŸ‘ 20    πŸ” 22    πŸ’¬ 0    πŸ“Œ 0
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β€ͺ
Please RT:
Looking forward to our International Symposium on "Microbial Networking - from organelles to cross-kingdom communities".
Highlight of our first funding period of our Collaborative Researc Center @mibinet.bsky.social, @dfg.de

www.sfb1535.hhu.de/mibinet

@hhu.de , @fz-juelich.de

19.02.2026 14:45 β€” πŸ‘ 10    πŸ” 9    πŸ’¬ 1    πŸ“Œ 0

What’s holding back clinical use of phage therapy in the UK?

Our workshop last year brought together international experts, biotech and regulators to find out

Meeting Report out now in Nature Microbiology with our take on the challenges and opportunities facing the UK phage therapy sector

14.02.2026 17:54 β€” πŸ‘ 46    πŸ” 21    πŸ’¬ 1    πŸ“Œ 0
Bacterial defense via RES-mediated NAD+ depletion is countered by phage phosphatases Many bacterial defense systems restrict phage infection by breaking the molecule NAD+ to its constituents, adenosine diphosphate ribose (ADPR) and nicotinamide (Nam). To counter NAD+ depletion-mediated defense, phages evolved NAD+ reconstitution pathway 1 (NARP1), which uses ADPR and Nam to rebuild NAD+. Here we report a bacterial defense system called aRES, involving RES-domain proteins that degrade NAD+ into Nam and ADPR-1β€³-phosphate (ADPR-1P). This molecule cannot serve as a substrate for NARP1, so that NAD+ depletion by aRES defends against phages even if they encode NARP1. We further discover that some phages evolved an extended NARP1 pathway capable of overcoming aRES defense. In these phages, the NARP1 operon also includes a specialized phosphatase, which dephosphorylates ADPR-1P to form ADPR, a substrate from which NARP1 then reconstitutes NAD+. Other phages encode inhibitors that directly bind aRES proteins and physically block their active sites. Our study describes new layers in the NAD+-centric arms race between bacteria and phages and highlights the centrality of the NAD+ pool in cellular battles between viruses and their hosts. ### Competing Interest Statement The authors have declared no competing interest. European Research Council, ERC-AdG GA 101018520 Israel Science Foundation, MAPATS grant 2720/22 Deutsche Forschungsgemeinschaft, SPP 2330, grant 464312965 Minerva Foundation with funding from the Federal German Ministry for Education and Research research grant from Magnus Konow in honor of his mother Olga Konow Rappaport Ministry of Aliyah and Immigrant Absorption, https://ror.org/05aycsg86 Clore Scholars Program

We found a new mode by which bacteria deplete NAD+ to protect from phages. And then we found how phages overcome this defense

Discovered by talented biochemist Dr Ilya Osterman, read the preprint: tinyurl.com/Narp-ap

A thread 🧡

29.01.2026 15:34 β€” πŸ‘ 46    πŸ” 15    πŸ’¬ 2    πŸ“Œ 0
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Postdoctoral position - Synthetic Biology / Bacterial Immunity - Research The Bikard lab at Institut Pasteur in Paris is seeking to hire postdoctoral researchers. We are investigating bacteria / bacteriophages interactions, and the genetic innovation that happens at this in...

🚨 Hiring Alert! 🚨My lab at Institut Pasteur is recruiting several Postdocs! We have exciting open projects in: 🦠 Synthetic Biology andπŸ›‘οΈ Bacterial Immunity. Come do great science with us in the middle of Paris! πŸ‡«πŸ‡·πŸ₯ research.pasteur.fr/en/job/postd...

28.01.2026 11:19 β€” πŸ‘ 74    πŸ” 81    πŸ’¬ 0    πŸ“Œ 2
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We are looking for a junior group leader in RNA biology to join us in WΓΌrzburg at the @helmholtz-hiri.bsky.social !

A generous funding package, a great collaborative environment, and a beautiful city are all included :)

Deadline for application is Feb 15; more information below πŸ‘‡

28.01.2026 09:28 β€” πŸ‘ 7    πŸ” 11    πŸ’¬ 1    πŸ“Œ 1
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PhD advertisement - Pausch lab | Patrick Pausch | 15 comments Please share! πŸ“€ The Pausch lab at Vilniaus universitetas / Vilnius University is looking to recruit PhD students to work on: βš”οΈ πŸ›‘οΈ: Bacterial Immune Systems (CRISPR, retrons, & beyond) 🧬 βœ‚οΈ: De...

Great opportunity to join the lab of @patrick-pausch.bsky.social !

www.linkedin.com/feed/update/...

23.01.2026 12:24 β€” πŸ‘ 5    πŸ” 5    πŸ’¬ 0    πŸ“Œ 0
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Characterising antibacterial toxins in the food-borne pathogen Listeria monocytogenes at Newcastle University on FindAPhD.com PhD Project - Characterising antibacterial toxins in the food-borne pathogen Listeria monocytogenes at Newcastle University, listed on FindAPhD.com

www.findaphd.com/phds/project... interested in bacterial antagonism? PhD opportunity in our team, see below. Please repost!

23.01.2026 10:33 β€” πŸ‘ 22    πŸ” 31    πŸ’¬ 1    πŸ“Œ 2
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Our new publication in #ISMEJournal (@isme-microbes.bsky.social) describes how Bacillus and Trichoderma works together to fight against the plant pathogen Fusarium, a superb collaboration with Zhihui Xu at Nanjing Agricultural University, including the experiments by @jiyuxie.bsky.social at #IBL
1/7

29.12.2025 10:30 β€” πŸ‘ 24    πŸ” 9    πŸ’¬ 1    πŸ“Œ 1
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A pentose, as a cytosine nucleobase modification in Shewanella phage Thanatos genomic DNA, mediates enhanced resistance toward host restriction systems | Applied and Environmental Microbiology Several phages extensively decorate their DNA building blocks, providing an effective protection against various host and phage-produced restriction systems. These modifications allow the phages to di...

Old and mighty: A novel cytosine nucleobase modification in phage genomic DNA renders the majority of restriction-based host defence systems useless. Great collaboration with the Bielefeld Gang. | Applied and Environmental Microbiology journals.asm.org/doi/10.1128/...

29.12.2025 09:44 β€” πŸ‘ 5    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0
Molecular Biology of Archaea: Life Through the Prism of Archaea In 1977, Woese and colleagues revealed Archaea as a distinct domain of life. Building on this insight, the discovery of Asgard archaea has strengthened the view that many hallmarks of eukaryotic cell…

Are you a long-time fan of Archaea, an extremophile-phile, or are you simply curious?

Either way, we have good news.
We’re delighted to announce the 2026 EMBO Workshop on Archaea, 6–10 July.

Sign up: meetings.embo.org/event/26-arc...

We look forward to seeing you in Cambridge, UK.

Please repost!

16.12.2025 12:00 β€” πŸ‘ 78    πŸ” 51    πŸ’¬ 2    πŸ“Œ 1
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Just got word that we are a go for the Bacterial Cell Biology and Development GRS and GRC at Southern New Hampshire University!

GRS will be on June 5-6, 2027

GRC will be from June 6-11, 2027

Block off your calendars Prokaryotic Cell Biologists!

More details to come! Please repost!

12.12.2025 14:58 β€” πŸ‘ 61    πŸ” 37    πŸ’¬ 3    πŸ“Œ 2
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Just realising again on my way to work: AI will never ever be able to bring the joy @eliza-coli.bsky.social images bring to me whenever I walk through my Institute's hallway. Thanks so much, Eliza!

05.12.2025 12:15 β€” πŸ‘ 7    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0

Phage-induced lysis may only be the beginning of something else. Great effort by Antonio (first and corresponding author) showing the occurrence of extracellular DNA synthesis and structuring!

www.biorxiv.org/content/10.6...

04.12.2025 16:01 β€” πŸ‘ 9    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0

So happy to announce our new preprint, β€œA geothermal amoeba sets a new upper temperature limit for eukaryotes.” We cultured a novel amoeba from Lassen Volcanic NP (CA, USA) that divides at 63Β°C (145Β°F) πŸ”₯ - a new record for euk growth!
#protistsonsky 🧡

25.11.2025 20:41 β€” πŸ‘ 494    πŸ” 165    πŸ’¬ 16    πŸ“Œ 32

Testrun underway.

25.11.2025 15:37 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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We have wondered what a complex archaeal cell might look like ever since 2014. It’s been a long road (and the journey is far from over), but it’s a good time to pause for breath and look. These Asgard archaeal cells are a surprise! And that is the joy of being a cell biologist.

07.11.2025 11:02 β€” πŸ‘ 162    πŸ” 49    πŸ’¬ 8    πŸ“Œ 4
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An Asgard archaeon with internal membrane compartments

Brilliant study led by @fmacleod.bsky.social and Andriko von KΓΌgelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!

www.biorxiv.org/content/10.1...

07.11.2025 10:44 β€” πŸ‘ 387    πŸ” 170    πŸ’¬ 10    πŸ“Œ 22
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Bacteria can sense when a virus starts shredding their genome β€” by detecting methylated mononucleotides.
Here’s the story of how we discovered the Metis defense system πŸ‘‡
www.biorxiv.org/content/10.1...

06.11.2025 04:59 β€” πŸ‘ 132    πŸ” 49    πŸ’¬ 4    πŸ“Œ 12
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πŸ“’ Postdoc position: Cell Biology of Cyanobacteria

in my group, as part of the Excellence Cluster "Microbes for Climate" (M4C) in Marburg, Germany.

More information at shorturl.at/wNnDT (see Project 2)

πŸ”—Apply at shorturl.at/VsEDl
πŸ“…Deadline: Nov 16, 2025

Please repost. #Postdoc

02.11.2025 19:13 β€” πŸ‘ 53    πŸ” 50    πŸ’¬ 2    πŸ“Œ 1
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Postdoctoral researcher in molecular ecology - Uppsala University Postdoctoral researcher in molecular ecology, Department of Ecology and Genetics, Uppsala University

πŸ“’ We have an open position for a postdoc to join my lab. It's a great position @animecol-uu.bsky.social, fully salaried for 2.5 years with all benefits.

www.uu.se/en/about-uu/...

The project is about transmission patterns of bacteria and antimicrobial resistance (AMR) in aquatic insects. 🧬🦠 (1/3)

27.10.2025 07:43 β€” πŸ‘ 69    πŸ” 78    πŸ’¬ 2    πŸ“Œ 3

Could not agree more 😁

11.10.2025 19:22 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Microbiology and Immunology – Faculty Position (Ladder Rank) – Assistant Professor University of California, San Francisco is hiring. Apply now!

Our Department of Microbiology & Immunology at UCSF is running a faculty search this year for a new Assistant Professor! Please see the ad below for details. Searching for a great colleague, mentor, and scientist!
aprecruit.ucsf.edu/JPF05807

25.09.2025 17:51 β€” πŸ‘ 16    πŸ” 24    πŸ’¬ 0    πŸ“Œ 0
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Engineering Spatial Control of Bacterial Organelles Bacteria were once thought to lack organelles, but it is now clear they confine cellular reactions using an array of membrane- and protein-based compartments. A central question, however, is how bacte...

New PrePrint from the Vecchiarelli and Mosalaganti (@shyamalm.bsky.social) labs! 🧡

Collaboration with the Giessen and Pi labs

Congratulations to co-first authors Y Hoang (@hoanghamyy.bsky.social) and Pankaj Jadhav!

www.biorxiv.org/content/10.1...

23.09.2025 17:38 β€” πŸ‘ 40    πŸ” 23    πŸ’¬ 2    πŸ“Œ 2

Thanks for having us on board, Khaled!

19.09.2025 14:34 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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ComFB, a widespread family of c-di-NMP receptor proteins | PNAS Cyclic dimeric-GMP (c-di-GMP) is a ubiquitous bacterial second messenger that regulates a variety of cellular processes, including motility, biofil...

And here is the published version of the work from @selimlab.bsky.social, @mygalperin.bsky.social, Dubnau labs and @thethormannden.bsky.social labs
(superb collaboration)

ComFB, a widespread family of c-di-NMP receptor proteins

www.pnas.org/doi/10.1073/...

19.09.2025 11:04 β€” πŸ‘ 16    πŸ” 7    πŸ’¬ 1    πŸ“Œ 0

Happy to share that our story on the bacterial archaellum was published today in @natmicrobiol.nature.com
www.nature.com/articles/s41...

Congrats to the authors: @sshamphavi.bsky.social @loumollat.bsky.social @mariejoest.bsky.social Najwa Taib and @sgribaldo.bsky.social

17.09.2025 17:41 β€” πŸ‘ 122    πŸ” 58    πŸ’¬ 7    πŸ“Œ 8

Willing to join us @pasteur.fr for a PhD for a project on how interactions between mobile genetic elements shape bacterial adaptation? Subject to be tailored to candidates with keen interest in evolution, genomics, computational biology, microbiology. Check www.pasteur.fr/en/education...

08.09.2025 08:56 β€” πŸ‘ 45    πŸ” 57    πŸ’¬ 0    πŸ“Œ 0
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A new theme issue of #PhilTransB examines the evolutionary history of bacterial immune systems, their modes of action, and the patterns how different bacterial immune systems are distributed across different ecosystems. Read: buff.ly/Z4qdxY1

05.09.2025 16:01 β€” πŸ‘ 38    πŸ” 27    πŸ’¬ 1    πŸ“Œ 1