DECISION Horizon2020

Acute decompensation of cirrhosis carries high 90-day mortality, but prediction remains challenging.
Adding signatures of large #extracellularvesicles may improve scores and prediction.
🎥 youtu.be/24-STOSjLeY

#EFCLIF @rautoupe.bsky.social @easlnews.bsky.social @europeliver.bsky.social
#LiverSky

YouTube video by concentris research management Emergency Granulopoiesis in Liver Failure: When the Immune System Goes into Chaos

In this video, we explore how emergency granulopoiesis, the rapid production of immune cells during crisis, becomes dysregulated in liver failure.

🎥 Watch here: youtu.be/ebN14TCLE24

#LiverSky #LiverFailure #LiverDisease #TranslationalResearch

YouTube video by concentris research management Data repositories and their access and publication rights | Masterclass in bioinformatics

📺New masterclass!
‘Data repositories & their access and publication rights’ covers the history of databases, an overview of repositories used in DECISION & provides a hands-on recipe on how to make the best out of different types of data
⏯️ youtu.be/aoA0WC1yaqs

#bioinformatics

DECISION's Year-in-Review2️⃣0️⃣2️⃣5️⃣
💙Networking session at EASL2025
🩵New publication on maladaptive emergency granulopoiesis
💙Met at Final General Assembly in Bologna
🩵Released 3 high-level lectures

We look forward to continuing our collaboration in 2026, finishing strong, and maximizing our impact 💪

YouTube video by concentris research management The Role of LSECtin in Regulating Inflammation in Advanced Chronic Liver Disease | DECISION Keynote

New keynote out now!
🌟 Prof. Rubén Francés explains how LSECtin shapes immune tolerance and inflammation in advanced chronic liver disease.
Watch here: www.youtube.com/watch?v=pY9H...

#LiverSky #cirrhosis #inflammation

Maladaptive emergency granulopoiesis predicts poor outcomes in patients hospitalized with decompensated cirrhosis Whether analysis of whole blood transcriptome assessed on admission of patients with acutely decompensated cirrhosis (ADC) without acute-on-chronic li…

New DECISION study in @jhepatology.bsky.social: maladaptive emergency granulopoiesis predicts poor outcomes in acutely #decompensatedcirrhosis.
This could guide early identification and novel therapies.
www.sciencedirect.com/science/arti...

#ACLF #LiverSky #Hepatology @easlnews.bsky.social

That’s a wrap on our final DECISION GA!

From COMBAT & PROSPECT updates to forward-looking discussions and feedback, we’re proud of our shared achievements and motivated to keep advancing ACLF & decompensated cirrhosis research together.

#LiverSky

Our final GA is a look back and forward - from major scientific milestones to future discoveries!
After a keynote by Prof. Rubén Francés, partners shared results on omics integration, biomarkers & systems medicine - and closed today with a masterclass on data repositories. #cirrhosis

Next week: the final DECISION General Assembly in Madrid! 🎉
Celebrating 5+ years of science, collaboration, & results
@rautoupe.bsky.social  @concentris.bsky.social 
@navarrabiomed.bsky.social 
@bioeticayderecho.bsky.social 
@medblab.bsky.social 
@europeliver.bsky.social 
@easlnews.bsky.social et al

The latest DECISION Masterclass is live!
💡 Clinical Bioinformatics – It’s More Than Pressing a Button with Núria Planell, Cristina Sanchez & David Gomez-Cabrero.

Watch here: https://youtu.be/UBm1_JGhw6M

#Bioinformatics #ClinicalResearch #ACLF

Today is #WorldHepatitisDay! We spotlight two DECISION partners deeply committed to #liverhealth:
🔬 @easlnews.bsky.social – advancing #hepatology research
🧡 @europeliver.bsky.social – amplifying the voice of liver patients
Together, we work toward a healthier future beyond ACLF.

#Cirrhosis

🔥 We’ve hit 50% recruitment in the #COMBATtrial!
Huge thanks to all involved!💙
@rautoupe.bsky.social @hopitalbeaujon.bsky.social @hospitalclinic.bsky.social @rwth.bsky.social @uni-muenster.de @brunslab.bsky.social @medblab.bsky.social @frankuschner.bsky.social

#LiverSky #ClinicalTrial

🎥 New keynote online!
Prof. Richard Moreau, Director of #EFCLIF, explores immune dysfunction in AD & #ACLF and suggests a common mechanism behind inflammation & immune deficiency.
Watch now 👉 https://youtu.be/KWoUbTsNjQM 
#LiverSky #Hepatology

🎉 Exciting news: We’ve surpassed 500 followers on @linkedin.com!
Follow us there for updates on trials, science, and more 👉 www.linkedin.com/company/deci...

#ClinicalResearch #DECISIONproject

Consider joining this event by @a-tango.bsky.social and @crowdhelix.com!
"Industrial Perspective on Drug Development Challenges for Clinical Trials"

📅 4th June 2025
🕚 11:00 am CEST / 🕙 10:00 am BST

Register via this link: inevent.uk/en/Crowdheli...

It’s #ClinicalTrialsDay! At DECISION, we’re proud of our COMBAT & PROSPECT trials advancing care in decompensated cirrhosis.
💡COMBAT Q&A videos in multiple languages help engage patients ➡️ www.youtube.com/playlist?lis...

Thanks to all who make our trials possible! #LiverResearch

✨ #PosterTour today at #EASLCongress 2025:
All our 3 Horizon2020 #LiverResearch projects in 1 session!

Topic: #Cirrhosis & #PortalHypertension
Chair: Maria Papp

💡 Big moments:

#AMMON-OHE model for post-#TIPS #encephalopathy (Rajiv Jalan)

#Terlipressin response in AKI-HRS w/ CKD (Frank Uschner)

Clinical trajectories of patients with cirrhosis and ascites receiving long-term albumin
#POSTER SAT-145-YI by Enrico Pompili (UNIBO) proposes a personalized management approach for patients with cirrhosis and ascites, based on real-world data from long-term albumin therapy. #EASL2025

🩺 Impact of diabetes mellitus on clinical outcomes in patients with acutely decompensated cirrhosis

#E_POSTER SAT-184-YI by Mimma Bonomo (UNITO) explores how coexisting diabetes mellitus affects prognosis in patients hospitalized with acute decompensation of cirrhosis.

#EASL2025

🦠The recovery failure of fecal microbiota diversity in patients after liver transplant is associated with a complicated postoperative course

#POSTER SAT-518 by @beccsipollsi.bsky.social from @rwth.bsky.social at #EASL2025

@brunslab.bsky.social
@easlnews.bsky.social

🧪 Acute kidney disease in acutely decompensated cirrhosis: impact on clinical outcomes

#POSTER SAT-122-YI by Alberto Calleri (UNITO) examines how acute kidney disease affects outcomes in patients with acutely decompensated cirrhosis.

📅 Presented at #EASLCongress | #EASL2025
@easlnews.bsky.social

❤️ Cardiac performance is impaired in patients with proven alcohol-related hepatitis and predicts 3-month mortality in this patient population

#POSTER SAT-503-YI by Pierre-Emmanuel Rautou (@inserm.fr, APHP, EF CLIF)

📅 Presented at the #EASLCongress | #EASL2025
@easlnews.bsky.social

Back in the Abstract Session: Theresa Wirtz presents her scRNA-seq work on monocyte subsets and ACLF risk.

@rwth.bsky.social
@brunslab.bsky.social
@easlnews.bsky.social

#Cirrhosis #ACLF #EASL2025"

Estefania Huergo presents methylation data in AD patients, selected as best Young Investigator abstract in Basic Science at #EASL2025 - Congrats! 🎉
@navarrabiomed.bsky.social
@easlnews.bsky.social
#Epigenetics #LiverResearch

Javier Fernandez (FCRB) is giving the hepatologist perspective on management of MDR infections in cirrhosis as part of the EASL/ESCMID Symposium: MDR infections - a challenge in decompensated cirrhosis at #EASL2025

#LiverDisease #Cirrhosis #Hepatology @easlnews.bsky.social

Is the etiological work-up of #PSVD a one-size-fits-all?

DECISION consortium member Lucile Moga from APHP takes part in EASL/ VALDIG's session on "Do's and Don'ts in the management of Porto-Sinusoidal Vascular Disease".

#EASLCongress #EASL2025 #LiverResearch
@easlnews.bsky.social

How do you build&lead a successful research team?
The next generation of PIs learned straight from the best in today's workshop “How to Start a Research Group: From Postdoc to PI" as @rautoupe.bsky.social shared practical insights on building&maintaining a high-performing team.
@inserm.fr #EASL2025

DECISION consortium member Sophie Lotersztajn from the French research institute @inserm.fr at a late-afternoon abstract session today at #EASLCongress in Amsterdam, the Netherlands, about #fibrosis, #hepatocyte and #liver #regeneration. 🩺

#EASL2025 @easlnews.bsky.social

Congrats on presenting your poster in the Track Hub 4 this afternoon, @beccsipollsi.bsky.social ! 🙌

🔬 #POSTER FRI-222 by Thierry Gustot (EF CLIF) proposes one-week criteria to assess the appropriateness of continuing intensive care in ACLF patients who are not candidates for liver transplantation.

#EASL2025 @easlnews.bsky.social