Journal of Neuroimmunology

Clear-positive cut off determination of flow cytometric MOG-antibody assay in Korea: Alignment with international MOGAD diagnostic standards MOG-Ab assay is a sensitive and specific biomarker that is indispensable in diagnosis of MOG antibody-associated disease (MOGAD). However, its accuracy can largely depend on a proper selection of pati...

www.jni-journal.com/article/S016...

Clear-positive cut off determination of flow cytometric MOG-antibody assay in Korea: Alignment with international MOGAD diagnostic standards MOG-Ab assay is a sensitive and specific biomarker that is indispensable in diagnosis of MOG antibody-associated disease (MOGAD). However, its accuracy can largely depend on a proper selection of pati...

Updated flow cytometric MOG-Ab cut-offs aligned with 2023 MOGAD criteria: Clear-positive: 90.7% PPV, in core demyelinating events: 100% PPV, High clear-positive: 100% specificity (lower sensitivity)

MOGAD diagnosis accuracy in Korea. #MOGAD #Neuroimmunology

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Acupuncture mitigates sciatic neuropathic pain in lumbar disc herniation via inhibiting spinal CXCL12/CXCR4-driven glial activation and neuroinflammation Lumbar disc herniation (LDH) is a prevalent degenerative spinal disorder causing chronic low back pain and sciatica through persistent neuroinflammation and central sensitization. Increasing evidence ...

Acupuncture eases neuropathic pain in lumbar disc herniation by blocking the CXCL12/CXCR4–ERK/NF-κB pathway, reducing glial activation and inflammation.
#Neuroscience #PainResearch #Acupuncture

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Hydrogen sulfide (H₂S) ameliorates sepsis-induced brain injury by upregulating heme oxygenase-1 (HO-1) to inhibit high-mobility group box 1 (HMGB1) release The incidence of brain injury in sepsis patients has been as high as 70 %, which has been a significant cause of septic patients' death. However, the pathophysiology of brain injury in sepsis is multi...

Hydrogen sulfide (H₂S) protects the brain from sepsis-induced injury by boosting HO-1 and blocking HMGB1. In mice, H₂S improved survival, cognition, and reduced brain damage - a potential therapy for sepsis-related injury.
#Sepsis #Neuroinflam #H2S #HO1 #HMGB1

Paper 👇

Neoehrlichiosis in patients with multiple sclerosis in Halmstad, Sweden: A case series Neoehrlichiosis is an emerging tick-borne infection. The documented cases of human infection demonstrate a varying symptomatology, diagnostic difficulties, a lacking clinical awareness of the conditio...

Neoehrlichiosis, an emerging, underdiagnosed tick-borne infection.
B-cell–depleting therapy increases risk and severity. #MS patients with fever, high CRP, or anemia may need further attention prior treatment initiation.
#InfectiousDisease #MS #Neoehrlichiosis

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Fast-forward through our day in neuroimmunology 🔬 — where every pipette move brings us closer to the next discovery.

#Neuroimmunology #LabWork #DataGeneration #PaperPrep #Pipetting #StainingHumanCells

Inhibition of microRNA-126-3p attenuates ischemic stroke by targeting endogenous neuroprotective receptor LRP6 in the Wnt/β-catenin signaling pathway MicroRNA-126 (miR-126) has emerged as a potential key regulator in ischemic stroke. Yet, its exact mechanism of action is still unexplored. This study aims to investigate whether miR-126 targets and r...

Insight into stroke recovery!
miR-126 worsens brain injury by suppressing LRP6 in the Wnt/β-catenin pathway. Blocking it restores signaling, reduces cell death, and improves outcomes - a promising new stroke therapy target.
#StrokeResearch ##miR126 #WntPathway

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It was an honor to sponsor the ISNI Young Session, Symposium 22 at #ISNI2025 in Chiba! 🌏

Congrats to our winner, @rosadelegadojimenez, and all speakers!

Special thanks to @HeinzWeindl for making this session a success! 🙏

#Neuroimmunology #ISNI2025 #NextGenerationScientists

Hypoglycorrhachia shapes the landscape of encephalitis. Low CSF/serum glucose flags infectious causes, while its absence points to autoimmune disease with higher ICU burden. #NeuroID #Encephalitis #Neuroimmunology

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Neurotoxicity associated with chimeric antigen receptor T-cell therapy Chimeric antigen receptor T cell (CAR-T) therapy involves reengineering patient-derived or donor-derived T cells to express a synthetic CAR that can recognise specific cell-surface antigens, independe...

CAR-T therapy has transformed hematologic cancers, but ICANS remains a major barrier. Diverse neurotoxicities, lack of biomarkers, and unclear mechanisms highlight an urgent unmet need. #CART #Neurotoxicity #crackingICANS

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www.jni-journal.com/article/S016...

⏰ Starting soon
Join this webinar to hear tips and strategies to promote your recently accepted or published work. @jnijournal.bsky.social
Register now: https://neuronline.sfn.org/professional-development/communication-and-recognition

Join us at #ISNI international congress 5-8 October in Chiba, Japan.
We are supporting the young investigator session.

The immune response within Alzheimer's disease: from the lense of peripheral monocyte-derived macrophages Alzheimer's disease (AD) is the most significant form of dementia characterized by neurodegeneration and higher-order cognitive decline affecting over 6.9 million Americans age 65 and older. Emerging ...

Beyond the brain: Our review explores how peripheral monocyte-derived macrophages (MDMs) shape Alzheimer’s disease pathogenesis—revealing new therapeutic opportunities outside the blood-brain barrier. 🧠🧬 #Alzheimers #Neuroimmunology

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When gut and nerves collide: A case of Neuromyelitis Optica Spectrum disorder after golimumab for ulcerative colitis Anti-TNF alpha agents, such as golimumab, are effective treatment options for moderate to severe inflammatory bowel disease. However, demyelinating syndromes have been reported as rare adverse events....

First reported case of AQP4+ NMOSD after golimumab for ulcerative colitis, presenting with intractable hiccups (Area Postrema Syndrome). Managed with plasmapheresis + rituximab, partial improvement.

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The immunology and neuropathology of the autoimmune nodopathies The autoimmune nodopthies have recently emerged as a discrete subtype of inflammatory neuropathy. They are characterised by the presence of IgG class autoantibodies directed against structural compone...

Autoimmune nodopathies mimic seronegative GBS or CIDP but have distinct biology and treatment response — often failing IVIg or steroids, yet improving with anti-CD20 therapy.
Early recognition can be life-changing.
#Neurology #RareDisease

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We’re excited to announce the Young Investigators Special Issue in the Journal of Neuroimmunology! We will spotlight early-career researchers and support the next generation of discovery. Submit your original research and let your work be seen and recognized.
#CallForPaper

Rapid one-step protocol for exploring immune cells in cerebrospinal fluid Flow cytometry analysis of the cerebrospinal fluid's immune cell subset profiles can be used to help in the diagnosis and prognosis of nervous system pathologies. However, the cells need to be analyze...

CSF cell analysis is key to understanding neurological diseases but has been limited by cell fragility. Millet Wallisky et al. introduce a rapid, one-step method for efficient CSF immune profiling

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www.jni-journal.com/article/S016...

Thinking about how seasons and environment affect myasthenia gravis. UV rays, humidity, and summer activity might play bigger roles than we know. More research ahead! #MyastheniaGravis #Science

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RIPK3-MLKL dependent necroptosis mediates depressive-like behavior by facilitating neuroinflammation Neuroinflammation is a critical pathophysiological mechanism of depression. But the sources and processes involved remain unclear. Recent reports suggest that necroptosis with pro-inflammatory propert...

Inflammation meets depression: Blocking hippocampal necroptosis eases depressive-like behavior in mice. Targeting RIPK3–MLKL could be a game-changer in depression. #Neuroscience #MentalHealth #DepressionResearch

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Association of TGFB1 and IFNB1 expression levels in peripheral blood mononuclear cells with multiple sclerosis with respect to proximal rs1800469 and rs2275888 eQTLs Multiple sclerosis (MS) is a central nervous system inflammatory disorder with evidence of peripheral immune system dysregulation. Complex signaling interaction of immune cytokines transforming growth...

TGFB1 is elevated in MS and correlates with IFNB1, which varies by disease phase but not IFN-β therapy.

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Stiff person syndrome spectrum disorders; more than meets the eye Stiff person syndrome spectrum disorders (SPSD) are a group of rare neuroimmunological disorders that often include painful spasms and rigidity. However, patients have highly heterogeneous signs and s...

Stiff Person Syndrome Spectrum Disorders are under-recognized, immune-mediated conditions with diverse presentations—advances in treatment and understanding offer new hope!

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Inflammatory cerebral pseudotumour as a rare manifestation of neuro-Behçet's disease: A case report and literature review Neurological involvement in Behçet's syndrome is rare but is associated with significant morbidity and mortality. Two subtypes of neuro-Behçet's disease (NBD) are typically described: parenchymal and ...

Don't miss this new case report on Neuro-Behçet's disease featured below 👇

www.jni-journal.com/article/S016...

Elevated serum levels of IL-10 family and IL-12 family cytokines in myasthenia gravis IL-10 and IL-12 family cytokines play important roles in various immunological diseases. This study identified a relationship between IL-10 and IL-12 family cytokines and the pathogenesis of myastheni...

High IL-10 and IL-12 serum levels in serum of Myasthenia Gravis patients could be used as potential biomarkers.

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Autoantigen and IL-2 activated CD4+CD25+T regulatory cells are induced to express CD8 and are autoantigen specific in inhibiting experimental autoimmune encephalomyelitis Experimental autoimmune encephalomyelitis (EAE) induced by immunization with myelin basic protein (MBP) is a self-limiting disease model of multiple sclerosis. CD4+CD25+Foxp3+T cells play a role in li...

CD4+ CD25+ T regs activated with MBP and rIL-2 ameliorate EAE and may serve as therapeutic agent for autoimmunity.

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www.jni-journal.com/article/S016...

Brucella neurotype induces CNS damage via the QUIN/NMDAR/Ca²⁺/CaMKII/ROS pathway, highlighting a promising therapeutic target
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Toxocara canis-originated recombinant C-type lectin improves the disability scores of experimental autoimmune encephalomyelitis in murine in vivo models The recombinant C-type lectin protein (r-CTL) derived from Toxocara canis larvae is thought to play a role in promoting regulatory T cell-dominant immune responses in toxocariasis. This study aimed to...

C-hype lectin protein derived from Toxocara canis larvae decreases disability scores in EAE, potentially through CD4+CD25+Foxp3+ Tregs

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Relapsing-remitting multiple sclerosis as a potential consequence of thalidomide treatment: A case report We present the first reported case of central nervous system (CNS) demyelination associated with thalidomide. A 29-year-old female with a history of prurigo nodularis was prescribed thalidomide after ...

A case report study: Thalidomide treatment is associated with RRMS

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www.jni-journal.com/article/S016...

Rasmussen encephalitis and localized scleroderma of the lower limb: Another piece of the puzzle. A case-report and literature review with individual participant data The co-occurrence of Rasmussen encephalitis (RE) and localized scleroderma (LS) is rare and poorly known. We describe the unique case of a 23-year-old patient with late-onset RE of the right hemispher...

The interplay between Rasmussen Encephalitis (RE) and localized Scleroderma (LS), a case report and literature review .

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Peripheral and central inflammation in depression: How large is the gap and can we bridge it with PET neuroimaging and neural-derived extracellular vesicles? Major depressive disorder (MDD) presents as a multifaceted syndrome with complex pathophysiology and variable treatment responses, posing significant challenges in clinical management. Neuroinflammati...

Interplay between peripheral & central nervous system inflammatory processes during major depressive disorder (MDD)

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www.jni-journal.com/article/S016...

Neuroinflammation and schizophrenia: The role of Toxoplasma gondii infection and astrocytic dysfunction Obligate intracellular pathogens such as the protozoan Toxoplasma gondii exploit host cell mechanisms to facilitate their survival and replication. While T. gondii can infect any nucleated mammalian c...

Toxoplasma Gondii infection is linked with Astrocytic distinction, which could be linked to the progression of Schizophrenia

Check this paper released today 👇 www.jni-journal.com/article/S016...