Jack Wilkinson

A letter from myself and @jdwilko.bsky.social that expands on this a bit more. Thanks to Fertility and Sterility for the opportunity.

doi.org/10.1016/j.fe...

Thanks Andy. Could you email antonia.marsden@manchester.ac.uk and she will generate an invitation link for you?

How to demonstrate ‘promise of the intervention’ ahead of an RCT of the intervention? If you’d like to participate in the final round of the Promise Delphi, even if you didn’t do Round 1, then get in touch!

Thanks Ian. So you’re saying that me repeatedly deleting and reuploading probably hasn’t helped the issue? 🙂

Any OSF-heads have suggestions here? I noticed a typo in a public OSF document I had uploaded. So I deleted and uploaded the corrected version. But the new version (a Word document, same as the previous doc) won't display - 'Unexpected server response'. Any ideas?

Did you have a chance to catch @davidhosch.bsky.social, @neiloconnell.bsky.social, @jdwilko.bsky.social, @nadiasoliman.bsky.social, @lesleyuttley.bsky.social discuss “trustworthiness” in clinical trial data? Watch the recording here bit.ly/4luQVMS

Happening now!

Have you wanted to understand what is meant by “trustworthy” research? Attend this #webinar where @davidhosch.bsky.social, @neiloconnell.bsky.social, @jdwilko.bsky.social, @nadiasoliman.bsky.social, @lesleyuttley.bsky.social, and more outline how to produce reliable evidence bit.ly/44GBtGP

Should be available later this month!

🔍 Systematic reviewers are the first line of defense for trustworthy science! 🛡️💡

Here’s why they must lead the charge for #ResearchIntegrity 👇
👉 www.cochrane.org/about-us/new...

#EvidenceBased #MetaAnalysis #OpenScience 🧠📊

Nice piece on the tool that @cochrane.org are collaborating on - "Investigating Problematic Clinical Trials in Systematic Reviews (INSPECT-SR)" – to identify potentially problematic randomized controlled trials in systematic reviews

Shout out to @jdwilko.bsky.social for all his work on this

Great to see increasing focus on the importance methodological rigour for the ethical conduct of patient focused research (thank you WMA Helsinki). Yet statisticians and other methods experts seem to often be left out of the conversation about solutions.

statsepi.substack.com/p/everybodys...

21 July PRF Webinar

Have you wanted to understand what is meant by “trustworthy” research? Attend this #webinar where @davidhosch.bsky.social, @neiloconnell.bsky.social, @jdwilko.bsky.social, @nadiasoliman.bsky.social, @lesleyuttley.bsky.social, and more outline how to produce reliable evidence bit.ly/44GBtGP

As soon as you say ‘it is unethical to randomly allocate people to a placebo’, you have shown you are not a serious commentator. You don’t understand the first thing about what trials involve.

Got to love that Bayesian reanalysis. Positive point estimate? "Probably works!"

This is fast and cheap and ethical, apparently

I'm being a bit silly of course - agreement between an RCT and a TTE tells us basically nothing. But the contradiction in the argument for TTEs usually goes unremarked.

What's that? The target trial emulation obtained the same answer as the RCT? Wow, I guess RCTs are generalisable after all! Perhaps we should perform them rather than using interventions on hundreds of thousands of people before we know whether or not they work, then doing a TTE?

Appreciate it!

Forget that too - that means something else in US slang vs UK…

Er…knock that up. Up. Not out. Different meaning

0197eb9d-ef92-8d6e-7fbd-dcdffc914833.share.connect.posit.cloud

You can tell me what you want (within reason) and I'll do it.

Alternatively, you can make a PR on my repo github.com/Dpananos/chi...

Ah, that’s great that you can knock that out so fast. I’m a dinosaur - Cursor not yet in my vocab

Ah yeah - thanks!

openepi.com/TwobyTwo/Two...

A man with more (any) time could do that Demetri!

I'm looking for a simple online calculator that will perform a chi-squared test and also a variety of common (not necessarily ideal) alternatives (e.g. Yates' correction, Fisher test - the more coverage the better). Ideally, it would present all of these results at once. Any suggestions?

This Delphi is live! Invitations are rolling out. Contact me if you have expertise in trials and would like to participate.

"Yes, nearly every statistical result in my paper contained an error, but significance changed for only one p-value" is not the strongest defence

Today’s challenge: explaining that long-run characteristics of estimators (e.g. A more precise than B) might not be evident in a particular instance (where B more precise than A).