Yeast ubiquilin Dsk2 scaffolds proteasome-containing condensates under stress via multivalent interactions – @castanedalab.bsky.social et al show how dynamic interactions among its STI1 domain & transient helices in its disordered region promote its phase-separation
link.springer.com/article/10.1...
The image illustrates a principle by which homomers can be polymerized by mutations or by multivalent small molecules.
In 2017 we showed that homomers evolve on the edge of supramolecular self-assembly. Here we show how to exploit this vulnerability so that ALL homomers can become bona fide drug-🎯. Delighted that Aim 3 of our @erc.europa.eu finally polymerized! Manuscript: 👉 rdcu.be/e27bT
09.02.2026 17:36 — 👍 20 🔁 6 💬 1 📌 0An excellent review on a fascinating topic !
07.02.2026 09:16 — 👍 4 🔁 0 💬 0 📌 0
Join 2026 BPS Lecturer Lewis Kay on Tuesday, February 24, 2:00 PM - 3:00 PM at #bps2026 for an informal discussion. Dr. Kay will share insights from his scientific career—from pioneering discoveries to lessons learned along the way—and reflect on how the field continues to evolve
29.01.2026 19:03 — 👍 7 🔁 6 💬 0 📌 0
📢 #MAINFRAME Symposium comes to Barcelona!
Experts in #AI, computational chemistry & small-molecule #DrugDiscovery meet to advance open, large-scale screening for 2,000+ human proteins.
📆 Mar 18–19
📍 Ateneu Barcelonès
ℹ️ https://shorturl.at/1aKKS
@ptck72.bsky.social
🚨WE'RE RECRUITING AT @irbbarcelona.org !!!!
--- ADVANCED GENOMICS FACILITY MANAGER ---
An amazing opportunity to help us drive the fight against cancer and other aging-related diseases using Single-cell, Bulk and Spatial genomics!!!!
APPLY NOW!!!!
recruitment.irbbarcelona.org/jobs/7124180...
How does protein folding change inside biomolecular condensates?
Our new preprint put forwards a framework for predicting this!! 🥳🥳🥳🥳 work by the talented @nathanieldhess.bsky.social
You can’t miss this video we shared today during the tribute to Dr. #JoanGuinovart.
Today, the scientific community, institutional leaders, colleagues, friends, and family gathers to honour the life and legacy of the founder and first director of #IRBBarcelona.
🎥 youtu.be/_SJ5Rudj2ik
Unfortunately this seminar has been cancelled. We will reschedule it and share the details here.
20.11.2025 11:31 — 👍 1 🔁 0 💬 0 📌 0
📌 Don't miss our plenary #seminar this week, with Prof. Edward Lemke, from @unimainz.bsky.social.
Host: Dr. @xsalvatella1.bsky.social, #IRBBarcelona
Register here ➡️ https://shorturl.at/I58yN
🧪
We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
Snapshot of a condensate near a lipid membrane with Swedish Research Council and Malmö University logos.
I'm hiring for a PhD position at Malmö University, Sweden!
The project will focus on molecular modelling of proteins, lipids, and biomolecular condensates at cell membranes.
More details and application form: tinyurl.com/4zm92365
Please feel free to share!
@vetenskapsradet.bsky.social | @mau.se
Thank you Fundación @bbvaenespana.bsky.social for supporting our collaboration with Michael Krieg of @icfo.eu !
03.10.2025 11:01 — 👍 5 🔁 2 💬 0 📌 0
Antoni Gaudí’s vision for the Sagrada Família, a church that’s been under construction for nearly 150 years, was never universally liked. George Orwell called the church “one of the most hideous buildings in the world.”
23.09.2025 16:48 — 👍 122 🔁 16 💬 17 📌 8
RFK Jr has vowed to find out what’s responsible for the rise in autism diagnoses, but scientists say he is ignoring answers from decades of research
go.nature.com/47R4brs
Are you a computational biologist who loves the outdoors & is thinking about faculty positions? Then check this out:
eeik.fa.us2.oraclecloud.com/hcmUI/Candid...
Tenure track position at the University of Wyoming - amazing colleagues, beautiful landscape, and fantastic work-life balance.
New paper on transcription factor phase separation published from my colleague Aseem Ansari's and my lab: Reconciling competing models on the roles of condensates and soluble complexes in transcription factor function authors.elsevier.com/sd/article/S...
09.07.2025 04:12 — 👍 30 🔁 12 💬 1 📌 0
Exciting news: our Board of Trustees has appointed @monicabettencourt.bsky.social as the CRG's new Director. Prof Bettencourt-Dias is expected to take up the post in 2026, replacing Dr. Luis Serrano, who will continue to maintain a research group at the institute.
www.crg.eu/en/news/moni...
Congratulations to RSC-ESR group committee member Adam Brookfield and his colleague, Dr Muralidharan Shanmugam, for winning the RSC Technical Excellence Prize for their operations of the EPSRC NRF for EPR in Manchester, UK. www.manchester.ac.uk/about/news/f...
01.07.2025 11:56 — 👍 3 🔁 2 💬 0 📌 0
🏆 La investigación sobre la causa del #autismo, premio #VanguardiadelaCiencia 2025!
¡Enhorabuena a las premiadas: Dra. Carla Garcia Cabau y Dra. Anna Bartomeu, del #IRBBarcelona!👏👏👏
➡️ https://shorturl.at/1hXF0
@lavanguardia.com @xsalvatella1.bsky.social
🧪
Gracias de parte de Carla y Anna !
29.06.2025 17:27 — 👍 1 🔁 0 💬 0 📌 0
Today’s uniquely challenging biotech climate may result in a more resilient sector nature.com/articles/s41...
rdcu.be/etg7h
“What is common knowledge in your field, but shocks outsiders?”
Most drugs have several activities in the human body, and discovery of these effects goes on for years after they are on the market.
...the amino-acid sequence does not necessarily determine 3D shape, because many of our proteins have functionally crucial disordered regions that don't really have a shape. (Sometimes they fold on binding, perhaps in a ligand-specific way, sometimes they don't.)...
15.06.2025 14:20 — 👍 13 🔁 1 💬 1 📌 0Here's an anniversary worth celebrating!
15.06.2025 03:37 — 👍 14 🔁 3 💬 2 📌 0Patent departments have budget targets that lead to “pound foolish” decisions to abandon all the time.
03.06.2025 19:17 — 👍 11 🔁 2 💬 0 📌 0
Sarah Shammas (University of Oxford):Opportunities in DNA binding provided by protein disorder Sonia Longhi (AFMB Marseille): Intrinsic disorder, phase transitions and fibril formation by the Henipavirus V and W proteins: a new hallmark of viral pathogenesis?
IDPSeminars is back with another seminar this week from @sarahshammas.bsky.social and @sonia-longhi.bsky.social!
Come hear about transcriptional regulation and viral pathogenesis!
Thursday June 5th!
PST 10 am EST 1 pm CET 7 pm!
Info: idpseminars.com
Signup form: forms.gle/3yCHeYvuuqLh...
Congratulations for this very important paper !
29.05.2025 16:20 — 👍 2 🔁 0 💬 0 📌 0indeed a great meeting !
15.05.2025 12:50 — 👍 2 🔁 0 💬 0 📌 0
Nuage Therapeutics, co-founded by our group leader Denes Hnisz was highlighted in recent Nature Spotlight article: www.nature.com/articles/d42...
Find out more about work in the Hnisz lab: www.molgen.mpg.de/3857230/tran...
@irbbarcelona.org @xsalvatella1.bsky.social
