Ciara Pugh

Thanks Manjunath! 🫶

In this study, we introduce a copolymer, MAASTY, that directly extracts membrane proteins along with their native lipids from the cell membrane, enabling structural studies by cryo-EM without detergents. This is a major step for the study of human membrane proteins in their native lipid environment.

✨ Absolutely delighted to share that our paper, “MAASTY: a (dis)ordered copolymer for structural determination of human membrane proteins in native nanodiscs”, is now finally out! ✨

www.nature.com/articles/s41...

I am excited to share our latest preprint presenting the structure of human NHE6, a key endosomal Na⁺/H⁺ exchanger involved in Christianson syndrome.

We bring together #cryo-EM, NMR, SAXS, lipidomics, and functional assays for an integrative analysis of NHE6 architecture, function, and regulation.

💖💛💖💛💖 BEN IN YELLOW !!! The Irishman takes the leader’s jersey on stage 10 after an insane ride from Healy and the squad 🥹

📸: Getty Images

#TDF2025

So proud of my PhD student @ciarapugh.bsky.social for delivering a brilliant flash talk at the @isbuc.bsky.social #CSSB25 seminar today! She shared our latest work on our native nanodisc-forming copolymer MAASTY and absolutely nailed it.
Heading to #3DEMGRC next week? Don’t miss Ciara’s poster!

Next flashtalk up: Ciara Pugh 🎤🔬 Excited to hear her latest work developing MAASTY to use at the interface of chemical biology and structural insights. Let’s see what molecular stories unfold! #CSSB25 #ChemicalBiology #StructuralBiology

The 23 Best Toy Show Moments Ever! It's almost time for this year's Late Late Toy Show and to celebrate we have rounded up our favourite moments from over the decades. See if you agree!

The 23 Best Toy Show Moments Ever!

www.rte.ie/entertainmen...

#LateLateToyShow

Stereochemistry in the disorder–order continuum of protein interactions - Nature Studies on protein–protein interactions using proteins containing d- or l-amino acids show that stereoselectivity of binding varies with the degree of disorder within the complex.

We did this crazy project where we tried to see if proteins could interact with their mirror image ligand. Seems impossible when proteins need to form 3D structures to interact. But what about if the interaction remains disordered???

www.nature.com/articles/s41...

The most stressed out I've ever been about Christmas was when I was 16 and I got my first ever job, working at M&S in Dundrum. As soon as I started I kept hearing these myths about the Christmas Eve Waste Sale, where all the food that wasn't sold on the 24th was marked down 90%.

This is amazing! @shervinnia.bsky.social resurrected our cryoEM-papers bot. At it's peak we had over 12k followers on Twitter, but the bot became defunct by a silly Musk policy (and it all went downhill from there).
If you want to keep up with #cryoEM papers, follow:
cryoempapers.bsky.social