Jordan Smoller

New preprint! We investigate the risk of algorithmic bias (across race/ethnicity, gender, and their intersection) in machine learning models predicting suicide attempts across 3 clinical settings in over 1.2 million patients.

osf.io/preprints/ps...

Genomic insights into substance use and disinhibitory disorders Externalizing spectrum disorders- spanning attention-deficit/hyperactivity disorder, conduct disorder, substance use disorders, and other disorders characterized by disinhibition - frequently co-occur...

Our multi-ancestry GWAS of EXTernalizing conditions (ADHD, substance use...) in ~4M people reveals neurodevelopmental risk, drug-repurposing targets, and yields one of the strongest psychiatric polygenic indices yet! 🧬🎉 doi.org/10.64898/202...

4/4 A HUGE 🙏thank you to the @pgcgenetics.bsky.social working groups and participants and amazing co-authors, with special shoutout to Josefin Werme, Wouter Peyrot, Alex Frei, Christiaan de Leeuw, Lucy Bicks, Ken Kendler, and @jorsmo.bsky.social. This work reflects collaboration at its best ❤️🧬

The missing heritability question is now (mostly) answered Not with a bang but with a whimper

Another great post from @sashagusevposts.bsky.social "The mystery of twin heritability comes to an ignoble end: no massive tranche of rare variants, no phantom interactions, just inflation."
theinfinitesimal.substack.com/p/the-missin...

***3 days left to sign up for our virtual conference on Precision Psychiatry***
+CME +free for students and trainees.
Featuring an amazing line-up of speakers.

New article written by Heather Stringer about precision treatment work in the mental health space by Kate Bentley, Ellen Driessen, @jorsmo.bsky.social, Leanne Williams, Conor Liston, and others www.apa.org/monitor/2025...

Ending the federal LGBTQ+ suicide prevention line is a public health failure Ending the federal LGBTQ+ suicide prevention line is a public health failure, write two leaders in prevention and crisis response.

Ending the federal LGBTQ+ suicide prevention line is a public health failure www.statnews.com/2025/07/12/e... via @statnews.com

The Surprising Scientists Hit by Trump’s D.E.I. Cuts

The Surprising Scientists Hit by Trump’s D.E.I. Cuts www.nytimes.com/2025/07/10/u...

Twin study suggests genetic variation influences how funny you think you are but not how funny you actually are. 😄

www.cambridge.org/core/journal...

PGS Browser: a public platform for personalized polygenic score interpretation Identifying individuals at elevated risk before disease onset is a cornerstone of personalized prevention, and polygenic scores (PGSs) have proven to be instrumental in this regard. In this study, we ...

New polygenic score resource from Mykyta Artomov and colleagues and @finngen.bsky.social
"All data and predictive tools are accessible via the PGS Browser (pgs.nchigm.org), an interactive web-based platform for PGS analysis and interpretation."

www.medrxiv.org/content/10.1...

The first rule in Trump’s Washington: Don’t write anything down A new culture of secrecy in government is taking root – among career staffers and new political appointees alike.

"career staff were told not to respond in writing to panicky grant recipients whose funding had been shut off to avoid a “paper trail,”
wapo.st/4kjmqsn

YouTube video by Center for Suicide Research and Prevention (CSRP) How to Help a Loved One Struggling with Suicidal Thoughts and Behaviors

🆕📽️Last week's webinar is available now on YouTube!

How to Help a Loved One Struggling with Suicidal Thoughts and Behaviors youtu.be/TMCAikdy2dQ?...

Thank you to everyone who joined, our speakers, moderator, @jorsmo.bsky.social & @matnoc.bsky.social @afspnational.bsky.social

YouTube video by Classic TV Channel Medic - Season 2 - Episode 1 - All the Lonely Night | Richard Boone, Mary Stewart, Robert Stevenson

the disturbing old days of medicine and psychiatry in this episode of Medic from 1956:
ulcerative colitis is caused by deep seated personality problems youtu.be/jki-rT92Uog

From back in the day when a two page research paper with no tables or references could still be transformative?

Sad to see this. I used to love these numbers when I was a kid

Reviewer #2 is now soliciting articles.

Polygenic Scores for Schizophrenia and Educational Attainment Predict Global Functioning Across Psychiatric Hospitalization Among People with Schizophrenia Question Is variation in global functioning among people with schizophrenia associated with genetic differences? Findings In this genetic association study of 5991 adults with schizophrenia and 59,79...

🚨🧬 New preprint! We tested whether PGS predicted global functioning across psychiatric hospitalization among 5991 people with schizophrenia. medrxiv.org/cgi/content/...

Trump’s NIH And NSF Cuts Estimated To Cost The U.S. Economy $10 Billion Annually Economists find public R&D drives U.S. productivity growth — and pays for itself

New Forbes story about the economic consequences of science cuts.

www.forbes.com/sites/johndr...

Thoughtful and thorough analysis.

1/n

9 Federally Funded Scientific Breakthroughs That Changed Everything

www.nytimes.com/2025/05/16/s...

Baby Is Healed With World’s First Personalized Gene-Editing Treatment

Another breakthrough made possible by federal funding The result “is a triumph for the American peoples’ investment in biomedical research”

Baby Is Healed With World’s First Personalized Gene-Editing Treatment www.nytimes.com/2025/05/15/h...

What am I supposed to say to this generation of young scientists? Undermining the future of American science is not a path to accountability — it’s a path to decline.

"let’s be clear: It isn’t institutions that are being punished. It’s the researchers who are the future of science in this country"

What am I supposed to say to this generation of young scientists? www.statnews.com/2025/05/07/u... via @statnews.com

Opinion | What Is Actually the Point of Treating the N.I.H. Like This? Efficiency is not being enhanced, nor is waste being eliminated at the N.I.H. Scientists are just left to wonder: Why?

www.nytimes.com/2025/04/11/o...

75% of US scientists who answered Nature poll consider leaving More than 1,600 readers answered our poll; many said they were looking for jobs in Europe and Canada.

75% of US scientists who answered Nature poll consider leaving www.nature.com/articles/d41...

Vaccine skeptic hired to head federal study of immunizations and autism A long-discredited researcher and vaccine skeptic will conduct a government study on whether vaccines cause autism.

wapo.st/4c2BMPr

Continuous time and dynamic suicide attempt risk prediction with neural ordinary differential equations npj Digital Medicine - Continuous time and dynamic suicide attempt risk prediction with neural ordinary differential equations

New work led by Yi-Han Sheu providing continuous-time and dynamic risk prediction models using Neuro-ODE with application to suicide risk prediction rdcu.be/eeIte

Large and Small Brains Apparently, mankind is prejudiced in favor of heavy brained persons. This view was bluntly expressed at a recent conference by a physician who averred that it is generally recognized that men with lar...

JAMA 100 yrs ago: "it is generally recognized that men with large heads seem to represent the intelligentsia of man, although this does not mean necessarily that a smaller headed man may not be quite as keen in his intellectual processes."

Large and Small Brains jamanetwork.com/journals/jam...

Opinion | A Reminder of What Pre-Vaccine America Was Like The worst manifestations of preventable diseases have faded from public memory.

We Need a Reminder of What the Pre-Vaccine Era Was Like www.nytimes.com/interactive/...

How the NIH dominates the world’s health research — in charts Abrupt cuts by the Trump administration to the US National Institutes of Health threaten progress in medical research globally.

How the NIH dominates the world’s health research — in charts www.nature.com/articles/d41...

Comparison of the multivariate genetic architecture of eight major psychiatric disorders across sex - Nature Genetics Genomic structural invariance, an extension of genomic structural equation modeling, identifies similarities and differences between males and females in the genetic architectures of eight psychiatric...

Out today, our method for comparing multivariate genetic architecture across groups of people, called Genomic Structural Invariance: www.nature.com/articles/s41...

(feat: @tuckerdrob.bsky.social @michelnivard.bsky.social @andrewgrotzinger.bsky.social @mijke.bsky.social @jorsmo.bsky.social et al.)

Great thread Paul. This comment in particular caught my eye--I had never thought to calculate this in planning for lab's funding but its very helpful (and daunting since this is the status quo and as you suggest, things may get much harder).