How do SMC complexes load onto DNA to get ready for loop extrusion?
@roisnehamelinf.bsky.social & co discovered that Wadjet, an SMC complex involved in bacterial DNA immunity, performs some impressive molecular gymnastics 🤸♂️🤸♂️🤸♂️.
Check out the new paper: www.cell.com/molecular-ce...
09.10.2025 14:43 — 👍 94 🔁 41 💬 3 📌 7
The figure was made by @falconierivisuals.bsky.social, so credit for that goes to her
18.07.2025 04:35 — 👍 2 🔁 0 💬 1 📌 0
We also discovered 4 previously uncharacterised proteins, which we named centromeric subunits 1-4 (CS module), surprisingly repurposed from the outer kinetochore Dam1/DASH complex. It will be very interesting to see how many other species contain this CS module
15.07.2025 16:49 — 👍 5 🔁 0 💬 1 📌 0
Holocentric kinetochore assembles into a self-contained, head-to-head dimers that entrap and loop DNA, creating a point-centromere-like architecture, suggesting that kinetochores might assemble into such foundational "unit modules" to drive diverse centromere architectures across species
15.07.2025 16:39 — 👍 4 🔁 0 💬 0 📌 0
Happy to share our latest work on the structure and assembly of holocentric kinetochores! Huge thanks to Ines for a very fruitful collaboration, Claudio for all the support, and congratulations to Christine and all co-authors!
www.biorxiv.org/content/10.1...
15.07.2025 16:36 — 👍 71 🔁 24 💬 7 📌 6
Investigator scientist @MRC-LMB,
GPCR structures and cryoEM method development
Also 🎸🎹🎻🏃♀️🧗♀️🚵♀️📷
Tenure-track professor (PI) at Fudan University.
Have been working on motor protein, microtubule, and cilia.
Recently also working with membrane proteins.
Associate Editorial Board member of Cytoskeleton Journal.
Lab website: https://tinyurl.com/22c3eymy
Cellular Structural Biology Wellcome DPhil Student at The University of Oxford.
Currently working in Peijun Zhang’s lab at The Oxford Division of Structural Biology.
Passionate about biomedical animation and science communication: Batisio.co.uk
Postdoctoral fellow, Tatsuo Fukagawa Lab, Osaka university
The Department of Biochemistry at the University of Oxford
Certified Medical Illustrator and Animator, Washington DC.
🧬Molecular & cellular #sciart
👉Website & portfolio: https://www.falconierivisuals.com/
📰Monthly newsletter, SciViz Simplified: https://www.falconierivisuals.com/subscribe-to-sciviz-simplified/
Scientific animator, structural biologist, creator of #MolecularNodes bradyajohnston.github.io/MolecularNodes/
Computational Cryo-EM/ET at Genentech
Love people, the outdoors and building stuff
Complexity is the enemy
All opinions my own
Postdoc with Sascha Martens and Tim Clausen at the Vienna BioCenter (VBC). #MSCA Fellow. Formerly University of Oxford and University of Antwerp.
structural cell biologist @EMBL 🇨🇦
Plants, Pathogens and Procrastination
Structural Biology to the rescue. Postdoc with Gabriel Lander at Scripps Research. PhD with Arne Moeller. #cryoEM ❄️🔬 🎹⛳
CryoEM, membrane proteins and whatnot
Predoctoral Research Assistant at the Llorca lab @cniostopcancer.bsky.social working on mTORC1 signaling and cryo-EM ❄️🔬. Intrigued by the structural mechanisms of protein assemblies involved in endomembrane signaling and trafficking 🧪.
Exploring the incredible world of biochemistry.
www.watchclockwork.com
Structural biologist at EMBL studying pre-mRNA splicing.
Postdoc at UC Berkeley MCB via UW Biochemistry. ACS fellow. Keen on using genetics to unravel new molecular mechanisms.
Studying cytoskeleton and mitosis, focused on tubulin and microtubules. Curious about bacterial division and Ftsz. Interested in computational modeling, all kinds of microscopy, experimental and theoretical biophysics, bio- and med- chemisty
A bio-physicist turned phys-biologist,
building models and software in genome biology.
3D genome structure in mitosis | DNA repair | meiosis.
A group leader at @IMBA_Vienna.
Dad x2.
