Thrilled to share our new work on how the human RAD51 paralogs cooperate to build and stabilize RAD51 filaments, published today in Nature.
www.nature.com/articles/s41...
Congratulations to all authors!
Thrilled to share our new work on how the human RAD51 paralogs cooperate to build and stabilize RAD51 filaments, published today in Nature.
www.nature.com/articles/s41...
Congratulations to all authors!
How do SMC complexes load onto DNA to get ready for loop extrusion?
@roisnehamelinf.bsky.social & co discovered that Wadjet, an SMC complex involved in bacterial DNA immunity, performs some impressive molecular gymnastics 🤸♂️🤸♂️🤸♂️.
Check out the new paper: www.cell.com/molecular-ce...
The figure was made by @falconierivisuals.bsky.social, so credit for that goes to her
18.07.2025 04:35 — 👍 2 🔁 0 💬 1 📌 0We also discovered 4 previously uncharacterised proteins, which we named centromeric subunits 1-4 (CS module), surprisingly repurposed from the outer kinetochore Dam1/DASH complex. It will be very interesting to see how many other species contain this CS module
15.07.2025 16:49 — 👍 5 🔁 0 💬 1 📌 0Holocentric kinetochore assembles into a self-contained, head-to-head dimers that entrap and loop DNA, creating a point-centromere-like architecture, suggesting that kinetochores might assemble into such foundational "unit modules" to drive diverse centromere architectures across species
15.07.2025 16:39 — 👍 4 🔁 0 💬 0 📌 0
Happy to share our latest work on the structure and assembly of holocentric kinetochores! Huge thanks to Ines for a very fruitful collaboration, Claudio for all the support, and congratulations to Christine and all co-authors!
www.biorxiv.org/content/10.1...