Christopher Seymour

Introducing JAMA’s Research of the Year.

Chosen by JAMA editors, the inaugural roundup highlights 9 of the most impactful, newsworthy, and novel studies published in the journal over the past year. 🧵

#JAMAROTY25

🔗 ja.ma/4pAihne

US Governors Launch Multistate Public Health Coalition This Medical News article discusses a new state-led coalition, called the Governors Public Health Alliance, to bolster disease detection and response as federal support wanes.

Amid federal funding cuts- and often controversial changes in guidance, 15 state and territorial leaders have come together to create the Governor’s Public Health Alliance.

Here’s what to know about the new coalition.

🧵 JAMA, @jamainternalmed.com, and @jamanetworkopen.com conclude #KidneyWk with impactful findings:

In stable AKI patients, indication-based dialysis enabled faster liberation from dialysis and reduced health care resource use compared to conventional thrice-weekly treatment.

ja.ma/4nIK3Mo

Image shows two JAMA journals stacked, with the text "jama.com JAMA Research" visible on both. Below, text reads: "19M AGO 10 MIN JAMA at Kidney Week, JAMA Summit Report on Firearm... JAMA Editors' Summary" followed by a purple 'Play' button.

In the latest episode of the JAMA Editor's Summary podcast, JAMA Deputy Editors Linda Brubaker, MD, and Preeti Malani, MD, MSJ, discuss the latest science published in JAMA:

➡️ JAMA at Kidney Week
➡️ JAMA Summit Report on Firearm Violence Reduction, and more

ja.ma/4nNumDM

🙄 Do intensivists ever agree on anything?

Peter Nauka & colleagues 👀 at variability in how we approach respiratory support for ICU patients:

www.chestcc.org/article/S294...

🫣 SPOILER ALERT: nope, we don’t agree

Happy 👻🎃 from #journal_CHESTCritCare!

@seymoc.bsky.social
@accpchest.bsky.social

JAMA article published online October 29, 2025, titled: Development and Validation of the Sequential Organ Failure Assessment (SOFA)-2 Score. Figure 3 shows distribution and ICU Mortality for SOFA-1 and SOFA-2 at ICU Admission.

SOFA-2, validated in >3 million ICU patients, incorporates contemporary organ support and treatments, showing strong predictive validity for ICU mortality in diverse international settings.

#LIVES2025 @esicm.bsky.social

ja.ma/4hE2H70

JAMA editorial, published online October 29, 2025, titled "A Revision to Organ Failure Assessment in Critically Ill Patients" by Christopher W. Seymour, MD, MSc. Discusses modern intensive care and the Sequential Organ Function Assessment (SOFA) score.

💬 Editorial: SOFA-2 improves the measurement of organ failure in intensive care by integrating current treatments and data-driven criteria, but further research is needed to address persistent challenges and optimize bedside utility.

#LIVES2025 @esicm.bsky.social

ja.ma/47pxgZb

Image reads: "Read papers from the JAMA Network." The ESICM logo is in the upper left, with the JAMA Network logo in the upper right. The background is a gradient of red.

📚 Development and Validation of the Sequential Organ Failure Assessment (SOFA)-2 Score:

Presented today in the #LIVES2025 Hot Topics session.

🔗 Free to read online: ja.ma/4qzouAz

JAMA Network Open article excerpt: "Rationale and Methodological Approach Underlying the Development of the Sequential Organ Failure Assessment (SOFA)-2 Score." Table details SOFA-2 and SOFA-1 score differences across organ systems.

From @jamanetworkopen.com: The SOFA-2 score updates the 1996 Sequential Organ Failure Assessment, reflecting current definitions, variables, and thresholds to grade organ dysfunction in critically ill adults receiving intensive care.

#LIVES2025 @esicm.bsky.social

ja.ma/3JuguA7

JAMA study: For severe metabolic acidosis and acute kidney injury patients, sodium bicarbonate infusion doesn't decrease all-cause mortality at 90 days. Population: 379 men, 248 women, mean age 67, across 43 French ICUs. Findings: Sodium bicarbonate 62.1%, Control 61.7%.

For #criticallyill patients who had both severe metabolic acidemia and moderate to severe acute kidney injury, sodium bicarbonate therapy did not significantly decrease day 90 all-cause mortality.

#LIVES2025 @esicm.bsky.social

ja.ma/3Ll9Exv

Text on a gradient red background reads: 'Read papers from the JAMA Network'. Logos for ESICM (in black box) and JAMA Network are also displayed. The background gradient goes from bright to dark red.

📚 Personalized Hemodynamic Resuscitation Targeting Capillary Refill Time in Early Septic Shock: The ANDROMEDA-SHOCK-2 Randomized Clinical Trial:

➡️ Presented today in the #LIVES2025 Hot Topics session.

🔗 Free to read online:

ja.ma/4oIaiUe

In this episode of the JAMA Author Interviews podcast, coauthor Mervyn Singer, MD, discusses the development and validation of the Sequential Organ Failure Assessment (SOFA)-2 score with JAMA Associate Editor Christopher Seymour, MD, MSc.

🎧 Listen now:

ja.ma/47wiUX0

The Space Needle rising above Fall foliage

Seattle in the Fall
📸Susan Kapp

JAMA Insights graphic on Women's Health, titled "Postpartum Hemorrhage." It outlines a management algorithm for immediate postpartum bleeding, including steps like gentle traction, uterine massage, IV access, and evaluation of bleeding etiology.

Postpartum hemorrhage is an obstetric emergency that has an incidence of 3% to 6% of births and accounts for approximately 27% of maternal deaths worldwide.

Learn more about the risk factors, assessment, and management of PPH: ja.ma/4qC9DFM

There are now just under 50 days to CCR Down Under 2025.

The programme is out - 8 superb trial results coming up.

Join us in Melbourne, in person or virtually, to discuss the best critical care trials in the world!

criticalcarereviews.com/meetings/ccr...

Incisional Negative Pressure Wound Therapy in Emergency Laparotomy This randomized clinical trial investigates whether incisional negative pressure wound therapy following emergency laparotomy in UK- and Australia-based patients prevented surgical site infection at higher rates than the surgeon’s choice of wound dressing.

Using incisional negative pressure wound therapy after emergency laparotomy did not reduce surgical site infections compared to standard dressings.

by None None, Atherton K (...) Wilkin R et 20 al. in JAMA #MedSky

📖 read the article:

Visual Abstract. Inhaled Sedation in Acute Respiratory Distress Syndrome

Among patients with moderate to severe ARDS, inhaled sedation with sevoflurane resulted in fewer ventilator-free days at day 28 and lower 90-day survival than sedation with propofol. https://ja.ma/4kxDZGm #ISICEM25

🧵 This week, JAMA EIC @kbibbinsdomingo.bsky.social, JAMA Associate Editor Kimmie Ng of @danafarber.bsky.social and VP Hannah Park visited research institutions in Mexico City and Cuernavaca to learn about the research being conducted there and present about trends in medical publishing.

The provisional schedule for the Critical Care Reviews Meeting 2025 is now available

12 major trial results across 3 days

CCR25 is supported by @visitbelfast.bsky.social @belfastcc.bsky.social @belfasttrust.bsky.social & Tourism Northern Ireland

criticalcarereviews.com/meetings/ccr25

🚩 Just out in @thelancet.bsky.social 🚩

African Critical Illness Outcome Study

➡️ Describing the burden of critical care in Africa
➡️ 1 in 8 inpatients are critically ill
➡️ ~70% cared for on general wards
➡️ ~50 don't receive basic critical care interventions

doi.org/10.1016/S014...

This Viewpoint explores the addition of host-directed therapy using immunotherapeutic agents to pandemic preparedness programs.

ja.ma/3CWmzlW

#MedSky

In critically ill adults with suspected sepsis, antibiotic regimens were safely reduced when guided by measurement of procalcitonin but not by C-reactive protein.

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#MedSky

Retail Pharmacies Get US Funding for Decentralized Trials This Medical News article discusses a new program to enroll underrepresented communities in decentralized clinical trials.

For the first time, the Biomedical Advanced Research and Development Authority (BARDA) has funded a trial at retail pharmacies in an effort to reach more diverse patients, speed recruitment, and improve outcomes.

ja.ma/4gHScy7

Figure. Time Intervala Between Left Without Being Seen and Return Emergency Department (ED) Visit

18.5% of patients who left the emergency department without being seen returned within 7 days, often due to difficulties in accessing non-ED care.

ja.ma/3ZXrIRS

JAMA Research at Critical Care Reviews 2024 (CCR Down Under) JAMA Senior Editor Derek Angus, MD, MPH, and JAMA Associate Editor Christopher Seymour, MD, MSc, discuss 4 critical care trials published in JAMA and simultaneously presented at the 2024 CCR Down Under meeting in Melbourne, Australia, with JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS.

Fantastic podcast covering the 4 trials presented at #CCRdownunder and simultaneously published in @jama.com

@kbibbinsdomingo.bsky.social (JAMA EiC) with Chris Seymour (CC editor) & Derek Angus (senior editor)

edhub.ama-assn.org/jn-learning/...

First post vibes

What is the impact of different oxygenation strategies for trauma patients, especially in the early phase after trauma?

Read more in this JAMA study published at #CCRdownunder.

https://ja.ma/4g6lTsr

What a meeting! Take the time to read this new evidence!