South Australian immunoGENomics Cancer Institute

A New Therapeutic Era in Metastatic Castration-Resistant Prostate Cancer | Pharmacy Times At 2026 ASCO GU, emerging targets are reshaping how mCRPC is treated.

📣Read about @saigenci.bsky.social Director, @chrissweens1.bsky.social, discussing advancements in treatment options for prostate cancer at @ascocancer.bsky.social GU Cancers Symposium 2026 in @pharmacytimes.bsky.social at www.pharmacytimes.com/view/a-new-t...

Spatial transcriptomics methods can struggle to scale on large datasets, or miss biological structure. Nora Liu @saigenci.bsky.social introduces DOMINO, a diffusion optimised contrastive learning framework for spatial domain detection, an accurate and scalable ST method.

Cancer cell-intrinsic inflammasome protein ASC links innate immunity with mitochondrial metabolism in driving pancreatic cancer - PubMed Pancreatic ductal adenocarcinoma (PDAC) is driven by genetic alterations in the pancreatic epithelium (e.g., KRAS) coupled with dysregulated innate immunity that triggers tumor-promoting chronic inflammation. However, the identity of innate immune molecular regulators as therapeutic targets in PDAC …

Very pleased to share our latest published work on the role of the innate immune inflammasome adaptor ASC in promoting pancreatic cancer. Thanks to all in our multinational team!
pubmed.ncbi.nlm.nih.gov/41654528/
@saigenci.bsky.social
@natcomms.nature.com

@saigenci.bsky.social is pleased to be part of the team, led by @petermaccc.bsky.social, awarded $5m from PCFA. @katmorel.bsky.social will bring her expertise to the project team, an extension of "The Daisy Project" led by @chrissweens1.bsky.social See more bit.ly/45PoNyy bit.ly/4alvFW1

📣Welcome to our Ainsworth Fellows in the TII program @saigenci.bsky.social, researching the role of inflammation in lung and upper gastrointestinal cancers. Grateful for the generous support of the Ainsworth Foundation. Drs Tamsin Lannagan, Eun-Jung In, Georgette Radford, Rhynelle Dmello. 🧪🔬👏

As part of the transition to Adelaide University, this page now represents @saigenci.bsky.social at Adelaide University. Thank you for following and supporting us on our journey under the University of Adelaide. Follow @AdelaideUni for university-wide updates and to explore what’s ahead.

📣 The University of Adelaide and @saigenci.bsky.social were proud sponsors of the Australian Ubiquitin Summit 2025, held 16-20 November in Lorne, Victoria bringing together leading scientists, clinicians and industry innovators to explore ubiquitin biology and targeted protein degradation (TPD). 🧪🔬👏

📣Kicking off @saigenci.bsky.social's 2025/26 summer research program with a morning tea celebrating the arrival of this year's students. An event filled with conversation and connection as students met each other, engaged with supervisors and SAiGENCI summer student alumni.🎉

Mechanistic modelling with ODEs and Virtual Cell Models with foundational models this morning at #EMBLAPhD with SAiGENCIs Lan and Anthony - looking forward to more #AI 🦾🤖 @emblaustralia.org @saigenci.bsky.social @acepigenetics.bsky.social

Congratulations to @saigenci.bsky.social's @aachinger.bsky.social awarded 2025 Sylvia and Charles Viertel Senior Medical Research Fellowship. Dr Achinger-Kawecka leads our 3D Chromatin Organisation Laboratory and receives $1.375m over 5 years to support her work. Read more at bit.ly/3Wva9HH

29 of Australia’s leading health and medical researchers elected as AAHMS Fellows - AAHMS The Australian Academy of Health and Medical Sciences (AAHMS) has announced the election of 29 new Fellows for 2025, recognising the nation’s most outstandi ...

📣 @saigenci.bsky.social congratulate Professor Jose Polo on his election as Fellow of the Australian Academy of Health & Medical Sciences (AAHMS). Jose is Program Lead for Cancer Epigenetics @SAiGENCI and Director @acepigenetics.bsky.social. Many congratulations Jose! aahms.org/news/29-of-a...

Luke is a group leader at @saigenci.bsky.social & @acepigenetics.bsky.social, within the University of Adelaide. He has extensive expertise in epigenetic regulation and a strong commitment to fostering creative, inclusive science. A perspective we can’t wait to share with our community!

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💗 𝐈𝐭’𝐬 𝐁𝐫𝐞𝐚𝐬𝐭 𝐂𝐚𝐧𝐜𝐞𝐫 𝐀𝐰𝐚𝐫𝐞𝐧𝐞𝐬𝐬 𝐌𝐨𝐧𝐭𝐡 💗

We’re spotlighting AEpiA member @aachinger.bsky.social (now at @saigenci.bsky.social) and Prof Susan Clark ( @garvaninstitute.bsky.social) for their research on epigenetic therapy in hormone-driven breast cancer.

#BreastCancerAwarenessMonth #AEpiA

📣Congratulations to Professor Brendan Jenkins, @saigenci.bsky.social's Program Lead for Tumour Inflammation and Immunotherapy, on being awarded the Japanese Cancer Association (JCA) International Award. The first Australian recipient! @jenkins-lab.bsky.social 👏

Thank you to the China International Talent Exchange Foundation for hosting our young ACE researchers! We shared our epigenetic research and cutting-edge technologies, whilst learning all about the pioneering research in Harbin, China. A wonderful exchange for ideas!🧪 @saigenci.bsky.social

📣Last night 90+ uni students attended the inaugural "Evening with Cancer Researchers". Hosted by @saigenci.bsky.social with representatives from University of Adelaide, UniSA's CCB and @sahmri.bsky.social. Great to see the enthusiasm of our next gen cancer researchers! @josundstrom.bsky.social 🔬

Welcome new @saigenci.bsky.social PhD students! SAiGENCI student reps Percy Zhang (Polo lab @acepigenetics.bsky.social ) and An Nguen were thrilled to welcome everyone with this warm gathering!

Flyer advertising upcoming webinars. Photos of the speakers are shown on the right. The words read: Dr Stefano Mangiola (SAiGENCI) “Improving the interpretability of AI models for cell biology and precision medicine” Dr Anh TN Nguyen (Monash) “Bridging pharmacology and AI: Accelerating GPCR drug discovery with deep learning” 26 August 2025 12 - 1 pm AEST

Next in our #AI webinars:

Stefano Mangiola @saigenci.bsky.social
talks AI models in #SingleCell and if they can uncover biological patterns

Anh TN Nguyen @monashuniversity.bsky.social shares how deep learning is accelerating #DrugDiscovery for GPCRs

More info www.biocommons.org.au/events/ai-se...

🧬 DNA’s message is only part of the story.

Dr @qizhang85.bsky.social @saigenci.bsky.social is decoding epigenetic modifiers - the hidden editors of gene expression - to uncover new cancer treatments.

🔗 More in our Impact Report: bit.ly/3EVhwD8

#DecodingTheUniverse #ScienceWeek

Learn more about South Australia's new university for the future.

@saigenci.bsky.social are hiring! Work with our fabulous Group Leader, Dr Luke Isbel and the Molecular Epigenetics Laboratory. Luke is seeking a highly motivated, creative researcher to join his team. See all the details at careers.adelaide.edu.au/cw/en/job/51... @acepigenetics.bsky.social

📣On Friday, @saigenci.bsky.social hosted a delegation from the Chinese biomedical industry as part of the SJTU-AU Innovation Connect 2025 Australia Biomedical Inspection. Thanks to Lan Nguyen, Michael Roy, Fuji Li and Jing Xu representing @saigenci.bsky.social 👏

Join #AI and #Immunology!

📢 Fully funded #PhD @saigenci.bsky.social: develop AI to chart immune diversity across the population, in #cancer.

CV, transcript, and a one-page statement by 30 August 2025 → www.linkedin.com/feed/update/...

#PhDOpportunity #MachineLearning #SingleCell

Stem cell funding to benefit epigenetic study

Huge congrats to the ACE team led by Prof Polo, Dr Sullivan, Dr Bhattacharjee, as well as Prof Lister & Dr Pope on their MRFF Grant, tackling the challenge of helping patients with rare neural diseases! @saigenci.bsky.social @ryanlister.bsky.social @perkinsinstitute.bsky.social tinyurl.com/5t4e9x6n

Fellows advance immunotherapy and tumour inflammation research

@saigenci.bsky.social are excited to welcome two new researchers through a fellowship program funded by the Ainsworth Foundation. Dr Georgette Radford and Dr Tamsin Lannagan join the Tumour Inflammation and Immunotherapy program. Read more at www.adelaide.edu.au/newsroom/new... 🔬🧪👏

Great work Team @saigenci.bsky.social raising over $900 for cancer research at today's The Longest Table morning tea. Donations are still rolling in at www.thelongesttable.com.au/fundraisers/... Supporting THRFG. Together let's #forkcancer! 👊

📣 @saigenci.bsky.social thrilled to congratulate Professor Lan Nguyen awarded funding through the ARC's 2025 Future Fellowships scheme for his project "Deciphering contextual multi-pathway crosstalk in cellular decision making". @saigenci.bsky.social's first Future Fellow! bit.ly/4lobxqv 💻🔬👏

👏Congratulations to Dr Mohamed Saad on your @curecancer.bsky.social Researcher of the Year 2025 award. Proud to have you continuing your important work @saigenci.bsky.social! 🧪🔬👊 www.curecancer.com.au/blog/celebra...

📅 SAVE THE DATE - Our much-loved #PhD Course is turning 10!

🧬 This year, our unique, two-week course will be held at SAiGENCI & focus on #AI in #biology.

👉 For more info, to have your say on course content or to sponsor the event, visit our website: bit.ly/3GNpEpF

Updated results from Australian-led ENZAMET trial highlighting long-term outcomes with XTANDI® in mHSPC to be presented at #ASCO25. @saigenci.bsky.social Director @chrissweens1.bsky.social key leader in the ENZAMET study. Check out the full story at oncologynews.com.au/latest-news/...

📣 @saigenci.bsky.social are now on @bsky.app! Follow us for the latest news on our exciting research!