Nicolas Minc

Group Leader Call at the @cbitoulouse.bsky.social in
Genome biology, projects at the interface with devbio will be given particular attention. please share :)
cbi-toulouse.fr/wp-content/u...

Tissue mechanics and systemic signaling safeguard epithelial tissue against spindle misorientation Bosveld et al. identified a multilayered system of safeguards that reuses homeostatic mechanisms to maintain epithelial integrity and cell number in the face of spindle misorientation. This work delin...

How resilient are tissues to cell mispositioning and loss, and how do they restore their cell numbers?

Check our latest work, from @ybellaichelab.bsky.social
Congratulations to all authors.

Artwork from the artist @lale-alpar.bsky.social
(lalealpar.com)

www.cell.com/developmenta...

Upcoming seminar by Meyer Rojas: Pre-training DNA language modelsto make them understand Biology at Institut Jacques Monod, Friday 20 March 2026 at 11:45. More info

Permeability-driven pressure and cell proliferation control lumen morphogenesis in pancreatic organoids - Nature Cell Biology Using pancreatic organoids, Lee et al. show that the balance between epithelial tissue permeability-driven lumenal pressure and cell proliferation affects ductal morphogenesis.

☕Using #pancreatic #organoids, Lee et al. show that the balance between epithelial tissue permeability-driven lumenal pressure and cell proliferation affects ductal morphogenesis.
bit.ly/4qozmjG

Very excited about this new preprint, in which @juliacoronasserna.bsky.social shows how cells ensure that fusion with another cell is irreversible!

www.biorxiv.org/content/10.6...

@biology-unige.bsky.social

👇

Really excited to share our new paper in @nature.com! We uncovered how a physical instability of the cytoplasm coupled with the cell cycle drives cytoplasmic partitioning in early embryos #zebrafish #drosophila. Read more in this🧵 www.nature.com/articles/s41... 🤩
@poldresden.bsky.social @mpi-cbg.de

✍️New preprint from the @minclab.bsky.social

📃 A Cell Size-Dependent Competition Between Geometry and Polarity Governs Nuclear and Spindle positioning in Early Embryos
🔗 www.biorxiv.org/content/10.6...

#JobOffer

💼 H/F Gestionnaire financier-e et comptable
📆 1e avril
📍 Institut Jacques Monod

Candidatez sur le portail emploi CNRS avant le 12 février🔗 emploi.cnrs.fr/Offres/CDD/U...

Latest work from the lab by Aude Nommick et al., in which we propose a "size-scaling" model for microtubule force exertion that regulates centrosome centration vs decentration during embryo development!
@ijmonod.bsky.social

www.biorxiv.org/content/10.6...

Cytoplasmic crowding acts as a porous medium reducing macromolecule diffusion | PNAS Intracellular transport of macromolecules is crucial for the proper functioning of most cellular processes. Although intracellular crowding is know...

Happy to highlight our collaborative work from our @ijmonod.bsky.social team with @destriano.bsky.social, B. Goyeau and M. Chabanon.
Cytoplasmic crowding acts as a porous medium that hinders macromolecular diffusivity.
Plus: a clever way to measure cell volume.
www.pnas.org/doi/10.1073/...

💼 Cell and Molecular Biology Research Engineer (M/F)

📍Institut Jacques Monod, @minclab.bsky.social
📆 June 1st

Apply on the CNRS job portal before February 13th 🔗 emploi.cnrs.fr/Offres/CDD/U...

✍️ The Guichet Lab published a new article

📖 @dev-journal.bsky.social
📃 Girdin controls the pace of 3D tracheal cell intercalation by coupling adherens junctions to the actin cytoskeleton in Drosophila
🔗 journals.biologists.com/dev/article-...

I am very happy (and a bit scared) to present to you what we have been working on over the last 4 years. This manuscript is exactly what I dreamt of when I started the lab and I could not be happier and prouder of the outcome!

📣 Stéphane Peyrégne, responsable d'équipe au sein de l' @ijmonod.bsky.social est lauréat du Prix Georges Brahms 2025 !

Plus d'informations 🔗 www.ijm.fr/prix-georges...

@cnrs-idf-villejuif.bsky.social @upcite.bsky.social

I'm humbled to receive the Paoletti Prize awarded by @cnrsbiologie.bsky.social 😌 and very grateful to present and past mentors !

Really happy to see my PhD first-author paper published in @nature.com! I’m very grateful to have worked with such a great team. Huge thanks to Urša Uršič, Michael Staddon, and Jan Brugués, as well as the @brugueslab.bsky.social, and the @poldresden.bsky.social and @mpi-cbg.de community!

📢 We're hiring a postdoc (33 months) in human evolutionary genomics / paleogenomics / statistical genetics, Paris 🇫🇷
Project on selection on disease-associated variants, integrating ancient genomes, GWAS, and Ancestral Rec. Graphs.
Start May 2026 (flexible).
Apply here: emploi.cnrs.fr/Offres/CDD/U...

La direction de l'Institut Jacques Monod ainsi ses équipes vous présentent leurs meilleurs vœux pour cette année 2026✨

The management of the Institut Jacques Monod and its teams wish you all the best for 2026✨

📣 New preprint from the @minclab.bsky.social

📃 A CROSS-SPECIES ANALYSIS OF CELL WALL MECHANOSENSORS
🔗 www.biorxiv.org/content/10.1...

Decreased cytoplasmic crowding via inhibition of ribosome biogenesis can trigger Candida albicans filamentous growth Nature Microbiology - During filamentous growth in the human fungal pathogen Candida albicans, a reduction in ribosome concentration leads to a decrease in macromolecular crowding. Inhibition of...

👉Excited to share our latest work @natmicrobiol.nature.com, revealing a decrease in cytoplasmic crowding during filamentous growth in the human fungal pathogen Candida albicans. Furthermore we found that inhibition of ribosome biogenesis can trigger filamentous growth in this pathogen
rdcu.be/eT1Su

Incredibly excited to receive an ERC Consolidator Grant. This recognition means a lot for what we’ve built so far and for what’s ahead.

Thank you to all collaborators and supporters.

Looking forward to getting this project going!

6 cellules d'oursins adoptant des formes différentes à cause du moule dans lequel elle se trouve : rond, conique, étoilé, carré, rectangulaire et bâtonnet. Tiré d'une étude de Nicolas Minc "Influence of Cell Geometry on Division-Plane Positioning"

Pour la dernière émission de @podcastscience.fm www.podcastscience.fm/emission/202... dont le thème était le carré, j'ai réalisé une chronique où je parle des travaux de @minclab.bsky.social ( @ijmonod.bsky.social ) qui met les cellules en boîte!
À lire et écouter sur SSAFT
ssaft.com/Blog/dotclea...

Tissue stress measurements with Bayesian Inversion Stress Microscopy Cells within biological tissue are constantly subjected to dynamic mechanical forces. Measuring the internal stress of tissues has proven crucial for our understanding of the role of mechanical forces...

Tissue stress measurements — our latest preprint is out: arxiv.org/abs/2512.00550
(publication coming soon!)
Fantastic work by the three musketeers — @luanger.bsky.social, @andreasschoenit.bsky.social and @fanny-wodrascka.bsky.social — in collaboration with P. Marcq!

Above: transverse sections of neurulating chick embryos stained for DNA (methyl green) and F-actin (TRITC-phalloidin), without and with the addition of the phorbol ester PMA. Below: computational simulations of pseudostratified epithelia, with different apicobasal/lateral tension ratios. Either PMA treatment in embryos, or lower ratios in simulations, cause epithelial instability evidenced by extensive cell extrusion.

Paper alert! Mechanical conditions preventing live cell extrusion during primary neurulation in amniotes. @sabr-bio.bsky.social article published as pre-proof in @cellsdev.bsky.social! doi.org/10.1016/j.cd...

Anthony A. Hyman will become EMBL’s next Director General.

He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999.

www.embl.org/news/people-...

We are looking to hire a postdoc to work on the regulation of microtubule nucleation in neurons. See advert attached. Contact me by email for any extra info.

#JobOffer

💼 Ingénieur de recherche H/F en biophysique de l'infection bactérienne
📆 12 Janvier 2026
📍équipe Bonazzi

Candidatez sur le portail emploi CNRS avant le 15 décembre 🔗 emploi.cnrs.fr/Offres/CDD/U...

bravo romain!!!

✍️ The Pintard Lab ( @ccdlab.bsky.social ) published a new article

📖 @jcb.org
📃 Intramolecular regulation of the MT-severing enzyme Katanin prevents futile ATP hydrolysis

🔗 rupress.org/jcb/article-...

Congratulations to Celia Municio-Diaz in the lab for this new publication, showing that Cell Wall mechanosensors taken from distant yeast species can still function and detect forces in the foreign cell wall of fission yeast cells!

@ijmonod.bsky.social @cnrsbiologie.bsky.social