Xin Gu Lab at DFCI/HMS

Congratulations Xin Gu, Ph.D., recipient of a Klingenstein Fellowship Award in Neuroscience for the project, "Elucidating the Role of the Midnolin-Proteasome Pathway in the Central Nervous System." @xingulab.bsky.social

xingulab.dana-farber.org

Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma Nardone et al. elucidate the mechanism of the midnolin-proteasome pathway, showing how midnolin achieves nuclear substrate selection and how established proteasomal components are repurposed to enable...

New work from @xingulab.bsky.social @sshaolab.bsky.social & Elledge lab report structure of Midnolin-proteasome complex & its role in controlling myeloma via ubiquitin-independent degradation. www.cell.com/molecular-ce...

Congrats Walter! This is amazing!

Thank you Issam!!!

Xin Gu, PhD, of Dana-Farber Cancer Institute

A new study in Molecular Cell led by @danafarber.bsky.social’s Xin Gu, PhD, highlights midnolin as a key regulatory component of proteostasis in plasma cells and suggests that restoring or enhancing this pathway could represent a novel therapeutic avenue in myeloma treatment. bit.ly/4l8Zuwu

Thank you Walter!:)

So happy and proud to see our story online!! Thank you, the midnolin team!

RNA meets protein decay Establishing the composition of RNAs and proteins that defines the identities and functions of cells relies not only on the regulated biosynthesis of these molecules, but also equally importantly, on…

~1 week left to register for the EMBO workshop on RNA meets protein decay! #EMBOrnaDecay
Come join us for a fun time and invigorating scientific discussions in Vienna!

meetings.embo.org/event/25-rna...

🎊🥳

Thank you so much Eilika☺️

Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma The midnolin-proteasome pathway degrades many nuclear proteins without ubiquitination, but how it operates mechanistically remains unclear. Here, we present structures of the midnolin-proteasome compl...

👏 Another chapter in the midnolin proteasome story from @xingulab.bsky.social www.biorxiv.org/content/10.1...

Check out these insights into (and the importance of) delivering ubiquitin-independent proteasomal substrates for degradation in the nucleus!

Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma The midnolin-proteasome pathway degrades many nuclear proteins without ubiquitination, but how it operates mechanistically remains unclear. Here, we present structures of the midnolin-proteasome compl...

Thrilled to share our collaborative work on the structural basis and myeloma disease link of the midnolin-proteasome pathway with Chris Nardone from the Elledge lab, Jingjing Gao from the Shao lab @sshaolab.bsky.social and all the co-authors who put in the hard work! www.biorxiv.org/content/10.1...